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  • 1
    ISSN: 1432-0533
    Keywords: Neurofibromatosis 2 ; Bilateral acoustic neurofibromatosis ; Ghal hamartomas ; Immunohistochemistry ; S-100 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bilateral acoustic neurofibromatosis (neurofibromatosis 2, NF2) accounts for less than 10% of all cases of neurofibromatosis and manifests itself with bilateral acoustic schwannomas, multiple schwannomas of spinal nerve roots, meningiomas, glial tumors and hamartomatous CNS lesions. We have observed dysplastic foci of immature neuroectodermal cells in the cerebral cortex and basal ganglia of six patients afflicted with neurofibromatosis 2, ranging from occasional clusters of immature, dysplastic cells to numerous, confluent lesions. These cells, although often polymorphic and multinuclear did not show mitotic acitivity or a tendency for neoplastic transformation. To determine the histogenesis of these foci, extensive immunocytochemical reactions were carried out with antibodies to a variety of glial, neuronal and nonneural cell lineages. With the exception of S-100 protein, no immunoreactivity was detectable. S-100 was consistently expressed in these foci, irrespective of their size, location, and degree of polymorphism. On the basis of cytological appearance, distribution and immunoreactivity we tentatively designate these foci as glial micro-hamartomas. Although we did not systematically analyze the CNS of patients with von Recklinghausen neurofibromatosis (neurofibromatosis 1, NF1), the present study strongly suggests that these micro-hamartomas constitute a morphological hallmark of bilateral acoustic neurofibromatosis (NF2).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 75 (1988), S. 621-626 
    ISSN: 1432-0533
    Keywords: Angiomatosis ; Meningo-cerebral ; Congenital ; Necrotizing encepholopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Various observations of diffuse meningocerebral angiomatoses, which cannot be satisfactorily classified with the common phakomatoses, have been reported. They may occur at any age, with familial accumulation or sporadically. Divry and van Bogaert were the first to draw attention to such conditions in adults, where meningo-cerebral angiomatoses seemed to be combined with sudanophilic leukodystrophy. However, subsequently the latter was considered to be due to hypoxic damage to the white matter. In other observations, the severe damage to the grey matter was more evidently of hypoxic origin. Observations on two newborn individuals, sporadic examples of diffuse meningo-cerebral angiomatosis and with severe necrotic changes in the grey and white matter, are reported and discussed. Published reports on the various age-related forms are summarized and a general designation is suggested, which includes the various observations under a general heading. A parallel will be drawn between the meningo-cerebral angiomatosis and Foix-Alajouanin's disease.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 144 (1986), S. 532-538 
    ISSN: 1432-1076
    Keywords: Cephalosporins ; Specific uses ; Pharmacokinetics ; Microbiologic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cephalosporins have been available for clinical use for nearly 20 years and a large number is presently marketed, including drugs with a wide range of different pharmaokinetic and microbiologic properties. While some of these agents have certain specific uses in which they excel, the cephalosporins have not replaced older antibiotics but do provide the physician with a broader range of choices for the treatment of many infections, allowing greater individualization of therapy.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0942-0940
    Keywords: Iodine-125 implantation ; Stereotactic interstitial irradiation ; inoperable cerebral gliomas ; cerebral radiation necrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Late radiation necroses constitute a hazard in low dose rate interstitial irradiation for inoperable gliomas. An incidence of 40% (8/20 patients) was found after permanent implantation of Iodine-125 seeds. This finding may even underestimate the real frequency, because follow-up of unaffected patients was shorter than in patients with radiation necrosis. The necrotic reactions caused a transient mass effect, which lead to a significant deterioration of performance scores. Further manifestations of late delayed radiation damage were observed in two patients. The occurrence of radiation necrosis was correlated with total radiation dose, amount of implanted radioactivity, and with velocity of tumour shrinkage. A mechanism underlying the development of radiation necrosis is proposed: A rapid shrinkage of tumour after interstitial Iodine-125 implantation may cause a significant irradiation of surrounding brain tissue, which was initially lying outside the target volume. Since most patients affected by radiation necrosis were children or adolescents, the risk of radiation damage should be minimized. This could probably be achieved either by reduction of irradiation dose, or by using temporary implants of Iodine-125.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 30 (1989), S. 274-279 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: An analysis of the coherent states for the noncompact supergroup Osp(2/2N,R) is presented. In contrast to Osp(1/2N,R), both typical and atypical representations have to be considered. The measure of integration, in general, for Osp(2/2N,R) coherent states is calculated; it is then used to construct the decomposition of unity for the special case of Osp(2/2,R). It is found, however, that the typical and atypical representations of Osp(2/2,R) have to be treated separately. It is verified that the coherent states for Osp(2/2,R) are "closest to classical'' in the sense of Perelomov.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 30 (1989), S. 2714-2720 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: Some physically realizable positive discrete series representations of the noncompact orthosymplectic superalgebra Osp(4/2,R) are considered. The decomposition of these Osp(4/2,R) representations on reduction to Sp(2,R)×SO(4) is studied in detail, and the corresponding state vectors are explicitly constructed by acting with the generators on a general lowest weight state. Some examples are given to illustrate these results for particular single-particle spaces.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 29 (1988), S. 1634-1639 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: Coherent states for the harmonic oscillator representations of the noncompact supergroup Osp(1/2N,R) are introduced and the invariant integration measure is calculated by studying transformation properties of supercoset variables. The generalized Bogoliubov transformation for mixed systems of bosons and fermions is also obtained. An example for the simple harmonic oscillator is given.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 41 (1985), S. 1821-1825 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Current genetics 10 (1985), S. 103-110 
    ISSN: 1432-0983
    Keywords: Yeast taxonomy ; DNA homologies ; Southern analysis ; Glycolytic gene probes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The genePDC1 ofSaccharomyces cerevisiae coding for pyruvate decarboxylase (E.C. 4.1.1.1.) was used as a hybridization probe to detect gene sequence homologies in different strains ofSaccharomyces cerevisiae and in other yeast species. Additionally six other genes coding for glycolytic enzymes as well as the genesURA3 of the pyrimidine synthetic andTRP1 of the tryptophan synthetic pathways were used. A restriction polymorphism for the BamH1 fragments carrying thePDC1 gene was evident within the speciesSaccharomyces cerevisiae. All strains definitely declared asSaccharomyces cerevisiae showed the same restriction patterns. Hybridizations of different intensities were observed only with species in the familySaccharomycetaceae. Hybridizations with different genes showed different degrees of conservation for certain DNA sequences.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 235 (1986), S. 200-205 
    ISSN: 1433-8491
    Keywords: Churg-Strauss-syndrome ; Mononeuritis multiplex ; Allergic granulomatosis ; Immunsuppressive treatment ; Immunovasculitis ; Churg Strauss-Syndrom ; Mononeuritis multiplex ; Allergische Granulomatose ; Immunsuppressive Therapie ; Immunvaskulitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über drei Patienten mit einer allergischen Granulomatose (Churg-Strauss-Syndrom) berichtet. In allen drei Fällen trat 2–10 Jahre nach dem Beginn einer pulmonalen Symptomatik eine Mononeuritis multiplex, begleitet von heftigen Schmerzen in den betroffenen Extremitäten auf. Während in einem Fall sich die neurologischen Ausfälle unter einer Behandlung mit Kortikoiden und Cyclophosphamid besserten, sprachen die beiden anderen Patientinnen erst auf eine Kombinationsbehandlung mit Thioguanin und Cytarabin an. In dem ersten Fall ließ sich die klinische Diagnose durch eine Biopsie aus dem N. suralis bestätigen.
    Notes: Summary Three cases of allergic granulomatosis (Churg-Strauss syndrome) are reported. The patients all presented 2–10 years after the onset of pulmonary symptoms with a mononeuritis multiplex, accompanied by sharp pain in the extremities involved. In one patient, the neurological findings improved under treatment with corticoids and cyclophosphamide; the other two patients responded to treatment with thioguanine and cytarabine. In the first patient, the diagnosis was confirmed by a biopsy specimen of the sural nerve.
    Type of Medium: Electronic Resource
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