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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 41 (1985), S. 125-127 
    ISSN: 1420-9071
    Keywords: 6-Hydroxydopamine ; intraocular administration ; continuous light ; persistent estrus ; female rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Following the intraocular injection of 6-hydroxydopamine, which can destroy the retinal dopaminergic neurons, female rats showed a normal estrous cycle in LD 12∶12 but not a persistent estrus in continuous light.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 147 (1988), S. 536-538 
    ISSN: 1432-1076
    Keywords: Pseudohypoparathyroidism ; Hypothyroidism ; Neonatal mass screening ; Bone age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A girl with type 1a pseudohypoparathyroidism (PHP) presented several hormonal abnormalities. Although she had eluded neonatal thyroid screening, she was diagnosed as having hypothyroidism at the age of 5 months. Thereafter, a diagnosis of PHP was made on the basis of skeletal features of Albright osteodystrophy and lack of both cyclic adenosine monophosphate (c-AMP) and phosphaturic responses after parathyroid hormone (PTH) infusion. The basal levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were higher than normal and showed exaggerated responses to luteinizing hormone-releasing hormone (LH-RH). There was no growth hormone (GH) response to arginine infusion, and the prolactin (PRL) response after thyrotropin-releasing hormone (TRH) infusion was also impaired. The stimulating guanine nucleotide-binding protein (Ns) activity of the erythrocytes was reduced to 66.9%. The skeletal age was not delayed at the age of 5 months in spite of the hypothyroid state, and it advanced following thyroxine and vitamin D treatments.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0942-0940
    Keywords: Brain neoplasms ; medulloblastoma ; lymphokine-activated killer (LAK) cells ; adoptive immunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An adoptive immunotherapy of 6 patients with medulloblastoma by lymphokine-activated killer (LAK) cells is described. They were from 2 to 9 years in age and had cerebrospinal fluid (CSF) dissemination of the tumours. All patients underwent the whole-neuraxis irradiation and chemotherapy. After the usual treatments, they were submitted to an adoptive transfer of one-haplotype identical LAK cells. The LAK cells were induced from peripheral blood lymphocytes (PBL) of their relatives with human recombinant interleukin-2 (rIL-2). 3–15×109 LAK cells were transferred intrathecally in 2–3 months. In 3 of 6 patients, neurological signs were improved and malignant cells had never been detected on CSF cytology after the adoptive immunotherapy. One among these 3 patients showed complete response in 20 months. Thus, this is an attractive approach for the treatment of medulloblastoma with CSF dissemination of the tumour which current therapeutic intervention can not cure.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 4678-4683 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Limiting molar conductances of the K+ and Cl− ions in heavy and light water have been determined at 5 °C as a function of pressure up to 1500 kgf cm−2 (1 kgf cm−2=0.9807×105 Pa) from the measured conductances and transference numbers of KCl. The residual friction coefficients (Δζ) are obtained for the cation and anion in D2O and H2O by using the determined limiting conductance and the bulk viscosity of solvent, and they are compared with the corresponding values predicted by applying the Hubbard–Onsager (HO) dielectric friction theory at various pressures below 1000 kgf cm−2. At atmospheric and high pressures, the solvent isotope and temperature effects on Δζ observed for the K+ ion are qualitatively in agreement with the theoretical prediction. However, the slightly positive pressure coefficients of Δζ(K+) are obtained in both solvents at 5 °C contrary to the theoretical prediction. Furthermore, Δζ(K+) in D2O at 5 °C is smaller than the theoretical one. These results suggest that another mechanism such as the passing through cavities one plays a more important role in ion migration of the K+ ion at lower temperatures and in D2O. On the other hand, the reverse solvent isotope and temperature effects on Δζ(Cl−), and the negative values of Δζ(Cl−) are found. These anomalies cannot be explained by the continuum theory.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 83 (1985), S. 280-287 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Limiting molar conductances of the K+ and Cl− ions in heavy and light water have been determined at 25 °C as a function of pressure up to 2 kbar from the measured conductances and transference numbers of KCl. The residual friction coefficients (Δζ) are obtained for the cation and the anion in D2O and H2O by using the determined limiting conductance and the bulk viscosity of solvent and compared with the corresponding values predicted by applying the Hubbard–Onsager (HO) dielectric friction theory at various pressures below 1 kbar. At atmospheric and high pressures Δζ of the K+ ion in D2O is larger than that in H2O just as predicted by the HO theory, but Δζ of the Cl− ion in D2O is smaller than that in H2O on the contrary to the theoretical prediction. The reverse solvent isotope effect on Δζ(Cl−) suggests that a microscopic viscosity in the vicinity of the relatively large ion is smaller than the bulk viscosity used in the continuum theory.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Materials Research 18 (1988), S. 25-45 
    ISSN: 0084-6600
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 54 (1989), S. 2400-2401 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new visible chemical laser analogous to excimer lasers in lasing principle has been studied. Laser oscillation has been observed in the red spectral range. To our knowledge this is the first demonstration of chemical laser oscillation in the visible spectral range.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 55 (1989), S. 2707-2708 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: New emission spectra have been observed from chemically produced excited oxygen. Evidence that the observed visible emission is due to oxygen dimer transitions is presented. Experimental results suggest that the observed oxygen dimer is stable O4 molecule rather than the usually observed Van der Waals-type dimolecular complex. The present system is discussed from the viewpoint of a new laser operating in the visible. The possibility of a similar oxygen-dimer laser operating in the near infrared is also discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 17 (1988), S. 0 
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study was undertaken to test the hypothesis that deregulated expression of the angiogenic phenotype by tumor cells is due to loss or inactivation of an angiogenesis suppressor gene(s). We used the technique of somatic cell hybridization to test the ability of untreated or chemical carcinogen-initiated hamster pouch keratinocytes, when fused to squamous epithelial neoplasms, to suppress tumor angiogenic activity by assaying hybrid-conditioned media (CM) in the avascular cornea of rat eyes. A non-angiogenic keratinocyte line, CL-2, derived from cultures of untreated epithelium and 3 lines of carcinogen-initiated keratinocytes, PN3, 5, and 7, of varying angiogenic potential were fused, using polyethylene glycol, to 3 tumorigenic, potently angiogenic, drug-resistant, hamster Serum-free 48-h CM from hybrid clones was prepared and assayed for angiogenic activity in rat corneas. CM from 5 hybrid clones derived from normal × neoplastic keratinocytes failed to induce an angiogenic response in 28 of 29 (97%) corneas tested. In contrast, CM from 4 hybrid clones derived from fusions between carcinogen-initiated and tumor cells were potently angiogenic in 24 of 25 (96%) corneas tested. Two angiogenesis suppressed hybrids clones were propagated in culture for an extended period of time, to permit chromosome segregation, and were found to re-express the angiogenic phenotype. These result indicate that angiogenesis is a recessive trait in normal hamster keratinocytes which is regulated in trans in these hybrid cells. It would also appear that loss or inactivation of angiogenesis suppressor function occurs early in the neoplastic process.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 5 (1986), S. 543-544 
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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