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  • 1
    Electronic Resource
    Electronic Resource
    3-Amino-3-deoxy-D-glucose: an antibiotic produced by a deep-sea bacterium (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 464-465 
    Details
    ISSN: 1420-9071
    Keywords: Deep-sea bacteria ; gram-positive ; antimicrobial activity ; Bacillus ; 3-amino-3-deoxy-D-glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Gram-positive bacteria isolated from deep-sea sediments of the Pacific basin showed considerable antibacterial activity. ABacillus strain, isolated from a sediment sample collected at a depth of 4310 m, was shown to produce 3-amino-3-deoxy-D-glucose, a known antibiotic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940457
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  • 2
    Electronic Resource
    Electronic Resource
    A case of adult neuronal ceroid-lipofuscinosis with the appearance of membranous cytoplasmic bodies localized in the spinal anterior horn (1987)
    Springer
    Acta neuropathologica 72 (1987), S. 362-368 
    Details
    ISSN: 1432-0533
    Keywords: Neuronal ceroid-lipofuscinosis ; Membranous cytoplasmic body ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of adult neuronal ceroid-lipofuscinosis was examined. The clinical picture was charaterized by gait disturbance, bulbar palsy and dementia. Histopathologically, diffuse neuronal loss was found throughout the central nervous system. The remaining neurons, predominantly in the motor nuclei of the spinal cord and brain stem, were swollen with storage material. Observed under the electron microscope the storage material showed various ultrastructures, such as lipofuscin-like bodies, pleomorphic lipid bodies, curvilinear profiles and finger-print profiles, in different regions of the central nervous system. In the ballooned neurons of the spinal anterior horn, many membranous cytoplasmic bodies and curvilinear profiles were intermingled within the same cell and were continuous with each other. Biochemically,N-acetyl neuraminic acid content was significantly increased in the spinal anterior horn. These findings suggest the localized increase of ganglioside in that region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687268
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  • 3
    Electronic Resource
    Electronic Resource
    Characteristic inclusions in the kidney of canine globoid cell leukodystrophy (1986)
    Springer
    Acta neuropathologica 69 (1986), S. 33-37 
    Details
    ISSN: 1432-0533
    Keywords: Globoid cell leukodystrophy ; Dog ; Galactosylceramide ; Kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kidney of a 7-month-old male Cairn terrier with globoid cell leukodystrophy (GLD) was investigated with light and electron microscopes. A few tubular epithelial cells in the inner medulla as well as some exfoliated cells in the lumina revealed PAS-positive cytoplasm in which needle-like structures were to be seen on occasion. At the ultrastructural level, characteristic inclusions of GLD were found in these cells. This observation indicates that in addition to our previous report in the kidney of murine GLD (Takahashi et al. 1984), kidney in canine GLD also is a site of abnormal storage of galactosylceramide, although so far no morphological or biochemical evidence of galactosylceramide storage was demonstrated in human GLD
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687036
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  • 4
    Electronic Resource
    Electronic Resource
    Cerebellar changes of the female mice heterozygous for brindled gene (1986)
    Springer
    Acta neuropathologica 69 (1986), S. 220-226 
    Details
    ISSN: 1432-0533
    Keywords: Brindled mouse ; Kinky hair disease ; Heterozygotes ; Purkinje cells ; Mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The brindled mutation is an X-linked neurological mutation in mice. Male mice hemizygous for the brindled gene have metabolic defects homologous with kinky hair disease in humans. Neuropathologically, the mutation is characterized by extensive neuronal degeneration associated with pronounced mitochondrial changes in cerebral cortex and abnormal arborization of Purkinje cell dendrites, which are most pronounced in the rostral vermis or anterior lobules. In the cerebellum of female mice heterozygous for brindled gene, Purkinje cells with abnormal dendritic arborization and with unusually enlarged mitochondria were also observed. Morphological changes in affected Purkinje cells in young heterozygotes were similar to those of young hemizygotes. However, in older heterozygotes, the changes were far less conspicuous, indicating the presence of some extrinsic factor(s) to compensate expression of the mutant gene in heterozygous brains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688297
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  • 5
    Electronic Resource
    Electronic Resource
    Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 216-223 
    Details
    ISSN: 1432-0533
    Keywords: Dementia ; Immunohistochemistry ; Neurofilament ; Phosphorylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these conditions the ballooned neurons contain phosphorylated epitopes recognized by monoclonal antibodies to neurofilaments, but not epitopes unique to Alzheimer neurofibrillary tangles and Pick bodies. The morphological features and immunohistochemical properties of ballooned neurons in these disorders bear resemblance to swollen neurons produced by neurotoxins that impair axoplasmic transport of neurofilaments. This finding, by analogy, suggests that impaired axoplasmic transport of neurofilaments may be a common mechanism in various dementing neurodegenerative diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688042
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  • 6
    Electronic Resource
    Electronic Resource
    Aqueductal lesions in 6-aminonicotinamide-treated suckling mice (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 243-250 
    Details
    ISSN: 1432-0533
    Keywords: 6-Aminonicotinamide ; Aqueduct “agenesis” ; Ependymal cell ; Hydrocephalus ; Suckling mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Suckling mice which received a single intraperitoneal injection of 6-aminonicotinamide on the 5th postnatal day, consistently developed hydrocephalus. During the early stages of hydrocephalus (7–9 days after injection), aqueductal lesions were characterized by edematous ependymal and subependymal cells, and spongy changes in the periaqueductal area, which resulted in aqueduct stenosis. Later stages (after 20 days post-injection) showed that these edematous changes totally subsided, leaving an obliterated aqueduct which was similar to that of human congenital hydrocephalus. At the completely obliterated area, ultrastructural investigation disclosed a normal-looking neuropil but no aqueductal lumen. In the remaining ependymal cell, increased intermediate filaments and lipid droplets occurred. These data suggest that acute ependymal cell degeneration during the perinatal period may result in the profile of aqueduct “agenesis” in human congenital hydrocephalus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688046
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  • 7
    Electronic Resource
    Electronic Resource
    Ultrastructural evidence of mitotic ependymal cells in 6-aminonicotinamide-treated suckling mice (1986)
    Springer
    Acta neuropathologica 70 (1986), S. 71-74 
    Details
    ISSN: 1432-0533
    Keywords: 6-Aminonicotinamide ; Ependymal cell ; Mitosis ; Suckling mice ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mitotic ependymal cells were encountered in 10-day-old mice treated with 6-aminonicotinamide, an antagonist of niacin. These occurred along the medial surface of the lateral ventricle and the ventral portion of the aqueduct. Electron microscopy revealed that both mitotic ependymal cells had eccentrically placed chromosomes without a nuclear membrane and well-formed gap junctions in contact with adjacent ependymal cells. Microtubules from a centriole radiated to the chromosomes. These data show that cell division occurs in morphologically matured ependymal cells in the postnatal brain under pathological conditions. We believe this to be the first ultrastructural demonstration of this phenomenon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689516
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  • 8
    Electronic Resource
    Electronic Resource
    Fetal origin of the medulloblastoma: Evidence from growth analysis of two cases (1986)
    Springer
    Acta neuropathologica 70 (1986), S. 227-234 
    Details
    ISSN: 1432-0533
    Keywords: Medulloblastoma ; CT scan ; Embryonal neoplasm ; Kinetics ; Growth rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Growth analysis of medulloblastomas was performed in two children. They initially manifested symptoms at the age of 3 years and 9 months and at the age of 2 months respectively. Computerized tomography (CT) scans were obtained at different points in each case. The growth curves were drawn on a semilogarithmic graph by calculating the tumor volume on CT on the assumptions that the tumor started from a single tumor cell and that the growth rate was constant. By extrapolating the curves back, tumor inception was estimated to have occurred respectively at the 14–23rd week and at the 16–17th week of gestation. Additional cell kinetic data were obtained from DNA analysis of surgical pathology specimens. Calculated cell-cycle times were 22–32 h for both cases. The S phases comprised 26.3% and 27% and the G0G1 phases 66.8% and 62% of the cell cycle, respectively, for case 1 and 2. Assuming a labelling index of 14%, the cell loss factors were estimated to be 97% and 74% (case 1 and case 2 respectively). The seventeenth week of gestation in humans corresponds to the timing of events occurring postnatally at days 3–18 in the developing cerebella of rodents, i.e., at the time of maximal activity in the migration and differentiation of the cells of the fetal external granular layer. Medulloblastomas have been experimentally induced in rodents by the injection of oncogenic viruses during the neonatal period, and statistical data on the epidemiology of human medulloblastomas have suggested a possible association with the contamination of polio vaccine by the SV 40 virus. Therefore, it seems reasonable to assume that these medulloblastomas originated in the cerebellum during the period of active development of the cerebellum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686076
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  • 9
    Electronic Resource
    Electronic Resource
    Pathogenesis of lupus dermatoses in autoimmune mice (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 79-83 
    Details
    ISSN: 1432-069X
    Keywords: New Zealand mice ; MRL mice ; BXSB mice ; Lupus-band test ; Anti-ssDNA antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The skin of New Zealand, MRL and BXSB mice was immunohistopathologically examined in order to study the appearance of skin immunologublin (Ig) deposition and its correlation with the occurrence of anti-single-stranded (ss) DNA antibodies in sera. Our studies revealed Ig deposition at the dermoepidermal junction (DEJ) in non-lesional skin and a significant age-related correlation between skin Ig deposition and serum anti-ssDNA antibodies. However, immunofluorescent study of autoimmune mice using anti-ultraviolet-irradiated DNA antiserum failed to demonstrate DNA antigens at the DEJ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414101
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  • 10
    Electronic Resource
    Electronic Resource
    Selective T/H separation by NH3 laser multiple-photon dissociation of CTCL3 (1985)
    Springer
    Applied physics 38 (1985), S. 99-105 
    Details
    ISSN: 1432-0649
    Keywords: 28.60 ; 33.80 ; 42.60
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The multiple-photon dissociation (MPD) of CTCL3 and the selectivity of T/H separation were investigated using a pulsed NH3 laser, whose radiation contained a few lines depending on operating conditions. When Xe was added to chloroform, the dissociation rate of CTCL3 increased at chloroform pressures below 2 Torr as a consequence of the removal of multiple-photon absorption bottleneck by collisions with Xe. The dissociation rate of CTCl3 decreased monotonically with increasing chloroform pressure from 0.2 to 7 Torr. The depletion of CHCl3 was not observed within experimental errors. The lower limit of the tritium enrichment factor in photo-products produced by one pulse irradiation was 570 at chloroform pressure of 2 Torr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00697448
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