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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 107 (1985), S. 671-674 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Mitochondrial encephalomyopathy (MELAS) ; Mitochondrial angiopathy ; Smooth muscle and endothelial cells ; Pial arteriole and small artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied cerebral blood vessels of two autopsied patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). All the main cerebral arteries in the proximal portion at the brain base and more distal portion at the cortical surface, as well as within the brain parenchyma were examined by electron microscopy. There was a striking increase in number of mitochondria in the smooth muscle and endothelial cells, which were most prominent in the pial arterioles and small arteries up to 250 μm in diameter and less frequent and severe in the larger pial arteries and intracerebral arterioles and small arteries. These vascular changes have not hitherto been described in MELAS, or in other disorders affecting blood vessels of the brain and other organs. It is suggested that the vascular changes are caused by primary mitochondrial dysfunction in the vascular smooth muscle and endothelial cells of the brain and that they constitute the pathogenic base of the brain lesions and their unusual distribution pattern in MELAS.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 75 (1987), S. 69-76 
    ISSN: 1432-0533
    Keywords: Human brain ; Cerebellar cortex ; Microcirculation ; Senile change ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The arterial structure of the cerebellar cortex was studied by vascular stain and in diaphanized specimens after intra-arterial barium injection. A scanning electron microscope study on the corrosion cast of the arteries was also performed. Arteries distributed in the cerebellar hemisphere are classified into cortical, subcortical, and medullary arteries. The patterns of arterial distribution are similar to those in the cerebral cortex. The cortical arteries are subclassified into superficial, middle, and deep cortical branches. The superficial branches are very fine, forming capillary networks in the molecular layer. The middle cortical branches terminate in the Purkinje cell layer, by dividing into several branches extending parallel to the plane of this layer. These branches connect with capillaries in both the molecular and the granular layers. The deep cortical branches give off some collaterals along the Purkinje cell layer and terminate in the granular layer, by breaking up into capillary networks. The Purkinje cell layer is marked by arterial branches ramified from the middle and deep cortical branches and no particular dense capillary networks are formed in the Purkinje cell layer. The brains of older patients show intertwining of the middle and deep cortical branches, some forming “rope-like” appearance. These patterns are similar to those seen in the cerebral cortex, but they were found, in older people, in the cerebrum.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 279 (1987), S. 558-560 
    ISSN: 1432-069X
    Keywords: Bullous pemphigoid ; Blister fluid ; Eosinophils ; Heterogeneity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 65 (1987), S. 549-558 
    ISSN: 1432-1106
    Keywords: Area 19 ; Sinusoidal grating ; End-zone inhibition ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have recorded extracellularly from single cells in area 19 of the cat for the purpose of providing a quantitative description of response characteristics. A prominent feature of this area is a high incidence of cells that are end-stopped. Drifting sinusoidal gratings were used to determine spatial and temporal characteristics of the discharge region. In addition, we have conducted independent tests to characterize end zones of receptive fields. When a grating patch was used to stimulate the discharge region alone, all of the cells showed a band-pass spatial frequency tuning characteristic. The optimal spatial frequency ranged from 0.1 to 1.13 cycles/deg, and the distribution had a peak at 0.4 cycles/deg. The bandwidth at half peak amplitude ranged widely from 0.7 to 3.3 octaves (mean 2.0 octaves). When gratings were also presented to the end zones, responses to stimulation of the central region were suppressed. The surround was phase-insensitive in that the relative phase between the grating in the two regions generally did not affect the strength of the suppression. To determine spatial characteristics of the end-zone inhibition, the spatial frequency of the end-zone grating was changed while that for the central pattern was fixed. All cells showed a bandpass characteristic for end-zone inhibition, but in each case, the tuning width was broader than that for excitation. The mean spatial frequency bandwidth of end-zone inhibition was 2.7 octaves. The peak of the inhibition generally coincided with the peak of the excitatory spatial frequency tuning of the discharge center. Considered together, these results show that neurons in area 19 share common properties with those in areas 17 and 18, but they exhibit phase-insensitve end-zone inhibition more frequently.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 65 (1987), S. 673-675 
    ISSN: 1432-1106
    Keywords: Dark-reared kittens ; Visual cortex ; GABA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Most cells in the visual cortex of dark-reared kittens are unselective for stimulus orientation and we examined the notion that this might be due to insufficiently developed gamma-aminobutyric acid (GABA) receptors. We recorded from cortical neurons and examined their sensitivity to iontophoretically applied GABA. As expected, most units were non-selective for orientation, but application of GABA suppressed impulse activity of these cells just as for orientation selective neurons. This result suggests that the development or maintenance of GABA receptors is not critically dependent on visual experience.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 147 (1988), S. 428-430 
    ISSN: 1432-1076
    Keywords: Malignant mesothelioma ; Neonatal tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Malignant mesothelioma was diagnosed in a 16-day-old boy. As far as we know this is the first report of a congenital case of this disease.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1076
    Keywords: Growth hormone deficiency ; Wilms tumour ; Growth hormone replacement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Wilms tumour was found in a Japanese boy aged 5 years 9 months with isolated growth hormone (GH) deficiency and some congenital anomalies. He had received pituitary GH replacement therapy from the age of 2 years 1 month to 4 years 7 months and after a 1 year interval he received biosynthetic GH for 2 months until the tumour became clinically apparent. This was the sixth known patient with GH deficiency to develop a malignant neoplasm during or after GH replacement therapy and the first with a solid tumour in Japan since 1975, when treatment with pituitary GH for patients with GH deficiency was introduced.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 100 (1989), S. 62-66 
    ISSN: 0942-0940
    Keywords: Vertebral artery ; cerebral aneurysm ; dissecting aneurysm ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present 6 cases with dissecting aneurysm of the intracranial vertebral artery who developed subarachnoid haemorrhage (SAH). The following procedures were performed in this series; trapping of the involved artery in 2, proximal occlusion of the vertebral artery with detachable balloon in 2, and proximal clipping of the vertebral artery in 2. Proximal occlusion of the vertebral artery in 4 and trapping of the vertebral artery in one gave excellent results. We believe the treatment of choice is proximal occlusion of the vertebral artery, either by open surgery or by interventional neuroradiological procedures.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 4565-4568 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Raman spectra were measured for liquid (0–0.7 GPa), crystalline cubic (0.7–0.9 GPa), and orthorhombic (0.9–3.5 GPa) phases in C2H2 at room temperature. For the orthorhombic phase, the high-pressure behavior of the librational and internal vibrations was obtained in a wide pressure range. The frequencies of all the librational modes increased monotonically with pressure, while those of the internal modes showed a variety of frequency shifts depending on vibrational mode. These high-pressure data will be of great use for the construction of theoretical models for the intermolecular interactions in crystalline C2H2.
    Type of Medium: Electronic Resource
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