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  • 1985-1989  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 2 (1985), S. 0 
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Effects of alloxan treatment on the levels of pineal melatonin, pineal N-acetylserotonin, and serum melatonin were investigated. Male rats were housed under a photoperiod of 12 h light: 12 h darkness and a temperature of 23 ± 3°C. Three weeks after alloxan (170 mg/kg) or carrier injection (s. c.), the animals were killed at mid-light (1200 h) and mid-dark (2400 h). Pineal and serum indoles were extracted and quantified by radioimmunoassays. It was found that pineal levels of N-acetylserotonin in the diabetic rats were significantly higher (P 〈 0.05) than those of the controls. Conversely, pineal and serum levels of melatonin in the control rats were significantly higher (P 〈 0.05) than those of the alloxan-induced diabetics. Our results suggest that alloxan-induced diabetics may decrease pineal melatonin synthesis in rats by reducing the activity of hydroxyindole-O-methyltransferase, resulting in a decrease in pineal melatonin secretion.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 72 (1988), S. 43-53 
    ISSN: 1435-1463
    Keywords: Prepubertal development ; pineal ; serum ; melatonin ; rat ; diurnal rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The levels of pineal and serum melatonin at mid-light and mid-dark of male rats under a photoperiod of 12 h light: 12 h darkness with age ranging from day 1 to day 42 postpartum were determined. At mide-dark, pineal melatonin levels were found to increase with age; when the body weight was considered, an early developmental rise (1-to-9-day old), an active period (11-to 17-day old), and a period of lower levels (after 21-day-old) were noted. Serum melatonin levels at mid-dark showed similar changes to the latter. At mid-light, this pattern of change was also present in pineal melatonin contents relative to body weight but was absent in serum melatonin levels. Our study indicated that weaning was not responsible for the pre-pubertal decline in pineal melatonin secretion. It was suggested that these changes in the secretory pattern of pineal melatonin may play a role in the development of the reproductive system in rats.
    Type of Medium: Electronic Resource
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