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  • 1
    Electronic Resource
    Electronic Resource
    Reflections on notochordal differentiation arising from a study of chordomas (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 9 (1985), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study of thirteen cases of chordoma serves to emphasize the occurrence of three different histological patterns; classical, seven; chondroid, three; and intermediate or mesenchymal, three. The study also suggests that more adequate sampling of these tumours detects the chondroid variant more readily. These varying patterns of differentiation in tumours of notochordal origin suggest that the parent tissue may have the potential to develop along similar lines in the embryo. Thus mesenchymal and cartilaginous tissue formed from notochordal cells could contribute to the formation of the nucleus pulposus and inner portion of the intervertebral disc cartilages. This concept contrasts with the previously held view that the notochord atrophies at an early stage in embryonic development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1985.tb02835.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chronic serum sickness glomerulonephritis: Passive immunisation inhibits the removal of glomerular antigen and electron dense deposits (1988)
    Springer
    Virchows Archiv 413 (1988), S. 551-553 
    Details
    ISSN: 1432-2307
    Keywords: Glomerulonephritis ; Chronic serum sickness ; Immune complexes ; Passive immunisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chronic serum sickness glomerulonephritis was induced in 20 Wistar rats, using radio-labelled, chemically cationised bovine serum albumin (BSA) as antigen. Four days after the last injection of antigen, when relocation of antigen within the rat had effectively ceased, the rats were given a single large intraperitoneal dose of either non-immune rat gamma globulin or anti-BSA rat gamma globulin. Ten days later the rats were killed. The rats which had received the anti-BSA globulin had significantly more antigen in renal cortex and in isolated glomeruli than the control group. They also had larger mesangial deposits as assessed by morphometry at electron microscope level; assessment of subepithelial deposits provided equivocal results. These findings provide direct confirmation that circulating antibody which is directed against an antigen which is trapped within deposits in the glomerulus will inhibit the removal of the antigen and deposits from the mesangium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00750396
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    In vivo somatic mutations in human lymphocytes frequently result from major gene alterations (1985)
    [s.l.] : Nature Publishing Group
    Nature 315 (1985), S. 343-345 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mutant HPRT" cells can be selected for by the purine analogue 6-thioguanine (TG) as described previously1'3. Lymphocytes obtained from the blood of healthy adult males were cloned at limiting dilution either in the absence of TG (unselec-ted, presumably HPRT+ clones) or in the presence of 2.5 g ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/315343a0
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    Paper (German National Licenses)
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