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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 111 (1989), S. 5707-5708 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 107 (1985), S. 5483-5490 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chromosome aberrations in two glioma cell lines were analyzed using biotinylated DNA library probes that specifically decorate chromosomes 1, 4, 7, 18 and 22 from pter to qter. Numerical changes, deletions and rearrangements of these chromosomes were radily visualized in metaphase spreads, as well as in early prophase and interphase nuclei. Complete chromosomes, deleted chromosomes and segments of translocated chromosomes were rapidly delineated in very complex karyotypes. Simultaneous hybridizations with additional subregional probes were used to further define aberrant chromosomes. Digital image analysis was used to quantitate the total complement of specific chromosomal DNAs in individual metaphase and interphase cells of each cell line. In spite of the fact that both glioma lines have been passaged in vitro for many years, an under-representation of chromosome 22 and an over-representation of chromosome 7 (specifically 7p) were observed. These observations agree with previous studies on gliomas. In addition, sequences of chromosome 4 were also found to be under-represented, especially in TC 593. These analyses indicate the power of these methods for pinpointing chromosome segments that are altered in specific types of tumors.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-072X
    Keywords: Chloroflexus aurantiacus ; Bacteriochlorophyll ; Precambrian ; Primary productivity ; Hot spring ; Sulfur cycle ; Microbial mats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Microbial mats which lack cyanobacteria occur at 50° to 65° C in the sulfide-containing Mammoth Springs of Yellowstone National Park. The principal organisms within these mats are filamentous bacteria which resemble Chloroflexus aurantiacus. The incorporation of [14C]-HCO 3 - into mat material depended upon both light and sulfide, and was not inhibited when complete natural light was replaced with far-red and infra-red radiation. [14C]-acetate was incorporated in a light-dependent reaction which was stimulated by, but did not require, sulfide. In situ experiments with microelectrodes demonstrated net sulfide uptake by the mat in the light, and net sulfide production by the mat in the dark, suggesting the operation of a sulfur cycle. Filamentous phototrophic bacteria isolated from the mat were incapable of sustained growth in the presence of O2. Simultaneous exposure of cultures to light and O2 caused degradation of bacteriochlorophyll c. The stimulation of light-dependent [14C]-HCO 3 - -uptake by sulfide was more pronounced in these isolates than in strains of Chloroflexus aurantiacus.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1041
    Keywords: felodipine ; metoprolol ; hydrochlorothiazide ; hypertension ; blood pressure ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Seventy-six uncomplicated hypertensive patients treated in General Practice, whose seated diastolic blood pressure (Phase V) (dBP) remained ≥95 mmHg after a minimum of 4 weeks treatment with metoprolol 50 mg b.i.d. as antihypertensive monotherapy, were randomized to receive the selective ‘calcium antagonist’ felodipine 5 mg b.i.d. or hydrochlorothiazide 12.5 mg b.i.d. in addition to metroprolol 50 mg b.i.d. The trial duration was 8 weeks, the dose of the felodipine or hydrochlorothiazide being doubled after 4 weeks if ‘control’ of BP (dBP 〈90 mmHg) was not achieved on the initial doses. Over the trial period of 8 weeks, felodipine reduced dBP from 102 to 85 mmHg and hydrochlorothiazide from 101 to 91 mmHg; the dBP reduction in the felodipine group was greater than that in the hydrochlorothiazide group (17 vs 9 mmHg) and the attained dBP lower in the felodipine group. About half of the patients in each group required the higher dose. Both regimes were effective and well tolerated. In the dosages used, felodipine was a slightly more effective antihypertensive drug than hydrochlorothiazide when added to metoprolol. There was no apparent difference in the tolerability of the two regimes.
    Type of Medium: Electronic Resource
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  • 6
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    Menasha, Wis. : Periodicals Archive Online (PAO)
    The Accounting Review. 60:1 (1985:Jan.) 146 
    ISSN: 0001-4826
    Topics: Economics
    Description / Table of Contents: BOOK REVIEWS, Harvey S. Hendrickson, Editor
    Notes: Departments
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 553 (1989), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Associations between photosynthetic responses to CO2 at rate-saturating light and photosynthetic enzyme activities were compared for leaves of maize grown under constant air temperatures of 19, 25 and 31°C. Key photosynthetic enzymes analysed were ribulose bisphosphatc (RuBP) carboxylase, phosphoenolpyruvate (PEP) carboxylase, NADP-malic enzyme and pyruvate, Pi dikinasc. Rates of CO2-saturated photosynthesis were similar in leaves developed at 19°C and 25°C but were decreased significantly by growth at 31°C. In contrast, carboxylation efficiency differed significantly between all three temperature regimes. Carboxylation efficiency was greatest in leaves developed at 19°C and decreased with increasing temperature during growth. The changes of carboxylation efficiency were highly correlated with changes in the activity of pyruvate, Pi dikinase (r= 0.95), but not with other photosynthetic enzyme activities. The activities of these latter enzymes, including that of RuBP carboxylase, were relatively insensitive to temperature during growth. The sensitivity of quantum yield to O2 concentration was lower in leaves grown at 19°C than in leaves grown at 31°C. These observations support the novel hypothesis that variation in the capacity for CO2 delivery to the bundle sheath by the C4 cycle, relative to the capacity for net assimilation by the C2 cycle, can be a principal determinant of C4 photosynthetic responses to CO2.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Maximum photosynthetic rate (Pmax in Zea mays L. was reduced to a much greater extent by neutral shading during growth than in the shade-adapted C4 grass Paspalum conjugatum Berg., although under a high light regime the Pmax of Z. mays was two-fold higher than that of P. conjugatum. In both species the shade-induced reductions of Pmax were not of stomatal origin since the intercellular CO2 concentration (Ci) was not decreased by growth under low light levels. The Ci of P. conjugatum (∼200 μPa Pa−1) measured at air levels of CO2 and high photon flux densities was 30% greater than that of Z. mays and, concomitantly, leaf water use efficiency was less. As with Pmax, specific leaf weight, leaf thickness and chlorenchyma volume were reduced to a greater extent by shading in Z. mays than in P. conjugatum. In contrast to Z. mays, bundle sheath chloroplasts of P. conjugatum contained well-defined stacks of grana. Mesophyll chloroplasts of P. conjugatum developed under a high light regime also contained large amounts of starch. This was not the case with Z. mays.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract The influences of shading during growth upon the activities of several photosynthetic enzymes were examined in NADP-ME type C4 grasses from open (Zea mays L.) and shaded (Paspalum conjugation Berg.) habitats. The substantial species-difference in maximum photosynthetic rate observed under a high light regime was correlated with large differences in both enzyme activities and leaf protein contents. With the exception of RuBP carboxylase activity, other photosynthetic enzyme activities in Z. mays were reduced by shading to a similar extent as maximum photosynthetic rate. In contrast, only PEP carboxylase and pyruvate, Pi dikinase activities were decreased by shading in P. conjugatum. As with maximum photosynthetic rate, other photosynthetic enzyme activities in P. conjugatum were relatively insensitive to irradiance during growth. Under a low photon flux density of photosynthetically active radiation (50 μmol m−2 s−1), the flow of [14C] label through photosynthetic intermediates in intact, shade-grown leaves of P. conjugatum was typical of C4 metabolism. This provides incontrovertible proof for the occurrence of C4 photosynthesis in shaded habitats.
    Type of Medium: Electronic Resource
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