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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 711-717 
    ISSN: 1432-1440
    Keywords: Alpha-1-microglobulin ; Beta-2-microglobulin ; Proteinuria ; Renal insufficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Alpha-1-microglobulin (alpha-1-m) is a low molecular weight glycoprotein (mw 25–33 KD) that is filtered through the glomeruli and reabsorbed in the proximal parts of the renal tubules where it is catabolized. Normal ranges were established for alpha-1-m (100 healthy controls) in serum (20–42 mg/l) and urine (3.5–8 mg/l). Alpha-1-m was then measured in 341 urine samples whose protein pattern had been classified as “pathologic” and “normal” according to microelectrophoresis. Increased alpha-1-m concentrations were found in 266 out of 280 pathologic urines (5% false negative) and in 3 out of 61 normal urines (4% false positive). Beta-2-microglobulin (beta-2-m), total protein or protein test strips showed a poorer correlation to the electrophoretic results. Measurement of alpha-1-m is, therefore, the most sensitive of these methods for the detection of proteinuria. In 90 patients with low molecular weight proteinuria and either with or without renal insufficiency alpha-1-m concentrations were determined in both urine and serum. While all patients had elevated urinary alpha-1-m concentrations, increased serum values were only found in renal insufficiency (Ccrea〈100 ml/min). Independently of these results, we were also able to establish that increased alpha-1-m levels are found at decreased glomerular filtration rates (Ccrea 〈70 ml/min). Pathologic alpha-1-m concentrations therefore only allow the conclusion of isolated tubular impairment when the GFR is greater than 70 ml/min. Data from 350 patients with various renal and hypertensive diseases showed that serum alpha-1-m is a more sensitive indicator of renal insufficiency, even in the so-called “creatinine blind” range (60–100 ml/min) of the GFR than either creatinine or beta-2-m.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1076
    Keywords: Glomerulonephritis, antiglomerular basement membrane antibody-mediated ; Renal failure ; Hydrocarbons ; Sniffing ; Plasmapheresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 16-year-old girl developed rapidly progressive glomerulonephritis and renal failure. The disease was associated with high titres of antiglomerular basement membrane antibodies in serum, linear deposits of immunoglobulin G and diffuse epithelial crescents on renal biopsy. Past history revealed heavy smoking and deliberate sniffing of Pattex glue, a mixture of hydrocarbons which possibly may affect the structure of glomerular basement membrane. After treatment by repeated plasmapheresis and drug immunosuppression autoantibodies disappeared from serum but renal function was not influenced. Renal damage is a potential hazard for glue sniffing adolescents.
    Type of Medium: Electronic Resource
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  • 3
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    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 37:4 (1989) 340 
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 2213-2224 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Guided ion-beam techniques are used to measure the cross sections for reaction of SiF4 with Ar+, Ne+, and He+ from thermal to 50 eV. Charge transfer followed by loss of F atoms are the sole processes observed. All SiF+x (x=0–4) products are observed, except for SiF+4 from reaction with Ne+ and He+, and Si+ from reaction with Ar+. At high energies, the dominant products are SiF+3 in the Ar system, and SiF+ in both the Ne and He systems. There is some evidence in the Ne system for an excited state of SiF+3 at 5.7 eV. In the Ar+ and Ne+ reactions, the observed energetics are consistent with literature thermochemistry, but with He+, reaction barriers are observed. A value of ΔH0f,298 (SiF+3)=−30.1±0.9 kcal/mol is derived, which is in agreement with previous values but is much more precise. The observed product distributions and energetics are explained by consideration of the potential energy surfaces and the difference in ionization potentials of the rare gases. Finally, the relationships of these reactions to plasma deposition and etching are discussed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 6898-6910 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The title reaction is studied using guided ion beam mass spectrometry. Absolute reaction cross sections are measured as a function of kinetic energy from thermal to 40 eV, and three endothermic product channels are observed. The dominant SiF++SiF3 channel is only slightly endothermic, while the SiF+3 +SiF and SiF+2 +SiF2 channels have much higher thresholds. The SiF+3 cross section magnitude is about half that of SiF+, while the SiF+2 cross section is an order of magnitude smaller than that of SiF+. A second feature which appears in the SiF+2 cross section is due to dissociation of SiF+3 . There is evidence that SiF+ and SiF+3 are produced via a direct mechanism. Competition between these two channels is interpreted in terms of molecular orbital correlations and qualitative potential energy surfaces. One surface is found to correlate only with the SiF+3 +SiF channel, while another correlates diabatically with this channel and adiabatically with the SiF++SiF3 channel. Competition on this latter surface has an energy dependence which is consistent with the Landau–Zener model. Reaction thresholds are analyzed to yield 298 K heats of formation for SiFx and SiF+x species. From an evaluation of these and literature values, we recommend the following values: ΔH0f(SiF+) =170.4±2.2 kcal/mol, IP(SiF)=7.54±0.16 eV, ΔH0f (SiF3)=−258±3 kcal/mol, and IP(SiF3)=9.99±0.24 eV.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 93 (1989), S. 1596-1604 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 63 (1988), S. 3118-3118 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Materials exhibiting strong Faraday rotation are of interest for components in laser systems. These include optical isolators, circulars, modulators, and switches in sizes ranging from microdevices for integrated optics to 30-cm-diam rotators for Nd:glass lasers used in inertial confinement fusion research. Properties of diamagnetic, paramagnetic, ferromagnetic, dilute magnetic semiconductors and free carrier rotators have been evaluated for various laser applications and for operation in the spectral range from the infrared to the ultraviolet and at various temperatures. Both crystalline and amorphous materials are considered; forms include bulk materials, fibers, and thin films. The characteristics of selected materials, including bismuth-substituted rare-earth iron garnets, Cd1−xMnxTe, and rare-earth doped glasses and crystals, are discussed. Relative figures of merit based on specific rotation, losses, cost, and special properties such as the nonlinear refractive index are also given.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 84 (1986), S. 1521-1529 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The endothermic reaction of Al+ with O2 is studied using a guided ion-beam apparatus. The reaction cross section is measured as a function of kinetic energy from 0 to 20 eV. The threshold energy for the reaction, E0, is determined from an empirical model to be 3.64±0.04 eV. Phase space calculations of the cross section performed with E0 as the only adjustable parameter yield a similar result, E0=3.60±0.02 eV, and predict the absolute magnitude of the reaction cross section within experimental error. We conservatively quote the threshold energy as 3.62±0.12 eV which is somewhat higher than the thermodynamic threshold calculated using literature thermochemistry, 3.40±0.16 eV. This may indicate that a slight barrier to the reaction exists, or that AlO+ is produced in an excited state, or that the literature thermochemistry needs revision. Our results suggest D00 (AlO+)≥1.50±0.12 eV and I.P.(AlO)≤9.75±0.13 eV.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 246 (1989), S. 97-105 
    ISSN: 1432-0711
    Keywords: Hypertensive pregnancy ; Proteinuria ; SDS-polyacrylamide gel electrophoresis ; Western blot ; Tamm-Horsfall glycoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary By using of modified urine preparation and a highly sensitive SDS-polyacrylamide gel electrophoresis (SDS-PAGE) we determined the urinary protein profile in 21 healthy males, 25 healthy females, 64 patients with uncomplicated pregnancy and 110 hypertensive pregnant women. The urinary protein patterns were similar in controls and in women with a normal pregnancy. There were no increase in the number of protein bands from the 1st trimester to term, and the electrophoresis pattern did not change in the postpartum period. In both groups, an intensively stained protein band with an apparent molecular weight of 105 kD was detected. The 105 kD band was significantly reduced or completely absent in 91 (83%) out of 110 hypertensive pregnant women. The urinary protein electrophoresis profile correlated significantly with the severity of the disease. The 105 kD band disappeared just before or simultaneously with the onset of clinical symptoms in 18 out of 32 hypertensive pregnant women followed throughout pregnancy. Postpartum the 105 kD in urine reappeared at 2 to 14 days after delivery in 49 of the 53 patients. Using a silver staining and Western blot, the 105 kD band was identified as Tamm-Horsfall protein, which is identical to the immunosuppressive glycoprotein uromodulin. The findings in the SDS-PAGE may reflect a transitory tubular dysfunction in cases of pre-eclampsia, which is usually reversible after delivery. The results of our study support the hypothesis of an immunological basis for this disorder.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 892-898 
    ISSN: 1432-1440
    Keywords: Diabetic nephropathy ; Urine analysis ; Albumin ; Single proteins ; α-1-microglobulin ; SDS-PAGE ; Diabetische Nephropathie ; Harnanalyse ; Albumin ; Einzelproteine ; α-1-Mikroglobulin ; SDS-PAGE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zahlreiche Untersuchungen haben in den vergangenen 10 Jahren belegt, daß die Quantifizierung von Albumin im Urin zur frühzeitigen Diagnose der diabetischen Nephropathie geeignet ist. Dabei wurde die Albuminbestimmung aufgrund ihrer hohen Treffsicherheit bei geringem methodischen Aufwand in den Vordergrund gehoben. Die parallele Untersuchung des Harnproteinspektrums mittels SDS-Polyacrylamidgelektrophorese zeigt jedoch, daß auch andere hoch- und niedermolekulare Proteine in den verschiedenen Stadien der diabetischen Nephropathie vermehrt ausgeschieden werden, so daß eine Erweiterung der reinen Albuminbestimmung um je ein makromolekulares (z.B. Transferrin) und ein mikromolekulares (z.B. α-1-Mikroglobulin) Protein sinnvoll erscheint. Nach der vorliegenden Untersuchung können beide Verfahren (kombinierte quantitative bzw. qualitative Analyse) in der Frühdiagnostik und der Verlaufskontrolle der diabetischen Nephropathie eingesetzt werden.
    Notes: Summary During the last ten years, several studies proved the applicability of urinary albumin quantification in the early diagnosis of diabetic nephropathy. Owing to its high accuracy and its comparable low methodological effort, only the albumin determination was emphasised. Parallel studies of urinary protein patterns, however, using sodium dodecylsulfate-polyacrylamidegel-electrophoresis demonstrated the increased excretion of other high- and low-molecular mass proteins in different stages of diabetic nephropathy. Consequently an extension of the mere albumin assay including a macromolecular (e.g., transferrin) and a micromolecular (e.g. α-1-microglobulin) protein seems meaningful. According to this study, both methodological lines (combined quantitative and qualitative analysis, respectively) are useful tools in the early detection and the follow up of diabetic nephropathy.
    Type of Medium: Electronic Resource
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