ISSN:
1432-0584
Schlagwort(e):
Chronic myelogenous leukemia
;
Interferon-antibodies
;
Interferon alpha-2 b
;
Natural human interferon alpha
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary A patient with Philadelphia-chromosome positive chronic myelogenous leukemia developed interferon antibodies on treatment with recombinant interferon alpha-2 b. Clinically this event corresponded with progressive disease. No cross-reactivity of antibodies with human leukocyte interferon was found by Western blot. Treatment was switched to human leukocyte interferon with an obvious clinical effect: WBC was reduced and platelet count stabilized, but the effect was transient and no hematologic remission was achieved. Human leukocyte interferon may be an alternative in CML-patients with neutralizing antibodies to recombinant interferon alpha.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00320360
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