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  • 1
    ISSN: 1432-0428
    Keywords: Immunocytochemistry ; glutathione-insulin transhydrogenase ; thioliprotein-disulphide oxidoreductase ; streptozotocin-diabetic rats ; obese (ob/ob) mice ; pancreatic acini ; islets of Langerhans ; kidney tubules ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glutathione-insulin transhydrogenase catalyzes the inactivation of insulin by splitting the hormone into A and B chains. We have localized this enzyme immunocytochemically by light microscopy in the pancreas, kidney and liver of both lean and obese (ob/ob) mice and similarly in normal and streptozotocin-diabetic rats. Localization was achieved by an antibody to glutathione-insulin transhydrogenase using a peroxidase-antiperoxidase technique. In comparison with tissues from control animals, positive immunostaining for glutathione-insulin transhydrogenase was increased in the obese mouse but reduced in the diabetic rat. Different tissues showed considerable variation in the amount of glutathioneinsulin transhydrogenase which could be detected. In the pancreatic islets there was little or no evidence for the presence of the enzyme in peripheral cells. In the kidney, immunocytochemical staining was found only in the proximal tubules. In the liver there was a generalised distribution of the enzyme, but the greatest concentration was in the periportal region. These observations parallel the biochemical data relating to glutathione-insulin transhydrogenase, indicating that different amounts of insulin degrading activity exist in different regions of tissues.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 10 (1983), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunoperoxidase techniques provide the pathologist with the capability for staining a wide range of antigens in tissue sections. More than 100 different antigens have been successfully demonstrated in fixed paraffin sections; other antigens can only lie visualized in frozen sections. This latter group particularly includes lymphocyte surface antigens detectable by monoclonal antibodies. This review describes the current state of the art and provides several illustrations of the use of monoclonal antibodies for the identification of T-lymphocyte phenotypes in fro/en section from cases of leprosy, mycosis fungoides, halo nevus, Kaposi's sarcoma, lichen planus and atopic dermatitis. Technical details and potential applications arc discussed. The growing availability of commercial immunostaining kits makes these techniques more accessible to the surgical pathologist; indeed a whole new range of truly specific, special stains are available, as pathologists we must simply learn to use them.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @classical review 34 (1984), S. 333-334 
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @classical review 33 (1983), S. 58-60 
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @classical review 33 (1983), S. 332-333 
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @classical review 32 (1982), S. 198-200 
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Lincoln, Neb. : Berkeley Electronic Press (now: De Gruyter)
    Journal of agricultural & food industrial organization 4.2006, 1, art9 
    ISSN: 1542-0485
    Source: Berkeley Electronic Press Academic Journals
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Economics
    Notes: Four articles have been published in this Journal about the historic cattle trial, Pickett v Tyson Fresh Meats, Inc., in which Plaintiff cattlemen alleged that Tyson/IBP--the buyer--used captive (contracted) supplies of cattle to manipulate the cash market in violation of the 1921 Packers & Stockyards Act (PSA). The first article gave a Trial's eye view by David Domina who served as co-lead counsel representing Plaintiff cattlemen. Domina's article led to a published comment by Thomas Green who was the lead attorney representing Tyson during the Trial phase of lengthy legal proceedings. Green alleged that Domina's article was "littered with rank speculation and baseless opinion." Domina countered that "proof is not litter, and evidence is not rank speculation" and that Green's commentary was "abusive." The adversarial exchange between Domina and Green was followed by another advocacy article in which William Rosales maintained that Pickett "represents an opportunity for the judiciary to reform the meatpacking industry (and) awaken the (PSA's) intended power to dethrone the economic kings of the meatpacking industry."After a five week Trial in Federal Court, the Jury found Tyson/IBP guilty on all counts and assessed actual damages of $1.28 billion over 2/1994 -10/2002. Justice for Plaintiff cattlemen was short, as the Trial Judge set aside the Jury's verdict--a rare but not unprecedented legal action--and entered summary judgment for Tyson. The Eleventh Appellate Court subsequently sided with the Trial Judge. On March 24, 2006, the United States Supreme Court denied without comment Plaintiff's Petition to rehear the case, thus ending legal activities in Pickett v Tyson and effectively killing similar legal action pending against two other major beef packers, Excel (Cargill) and Swift (ConAgra).This article emphasizes three significant and troubling legal and economic issues from the historic litigation: (1) the Courts' narrow and extreme interpretation of the antitrust rule-of-reason; (2) the Courts' endorsement of a "meeting the competition" defense, and (3) whether the Courts inserted themselves above the Jury as fact-finders in the case, contrary to the 7th Amendment to the U.S. Constitution that establishes the Jury as the only fact-finder in civil litigation.In essence Pickett was filed under the Packers and Stockyards Act, tried under Sherman and Clayton antitrust law, and overturned, in part, under the Robinson-Patman Act.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 38 (1984), S. 487-487 
    ISSN: 0066-4227
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: To examine the relationship between blood pressure (BP) and pulse transit time (PTT) as measured by the time between the ECG R-wave and an associated peripheral pulse, BP was recorded via a radial artery catheter in 3 hvpertensive subjects who underwent a variety of conditions to alter BP. Overall. 70% of the data was usable. Absolute levels of systolic blood pressure (SBP) but not diastolic blood pressure (DBP) were found to correlate appreciably with PTT. There were significant associations between PTT and both SBP and mean BP but not DBP for direction of BP change. With large SBP changes (〉 4 mmHg) an increase in the strength of association occurred in 14 of the 21 conditions across subjects. Overall, PTT did not accurately predict actual BP. PTT and SBP covaried more appreciably in these hypertensives than has been reported for normotensives.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 45 (1980), S. 126-130 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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