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  • 1
    Electronic Resource
    Electronic Resource
    Indolic Substances in Plasma, Cerebrospinal Fluid, and Frontal Cortex of Human Subjects Infused with Saline or Tryptophan (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 37 (1981), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Psychiatric patients undergoing the psychosurgical operation of stereotactic subcaudate tractotomy were infused intravenously with either saline or L-tryptophan (15 mg/kg/h). Plasma, lumbar cerebrospinal fluid (CSF), ventricular CSF and a specimen of frontal cortex were collected. The relationships of plasma concentrations of substances claimed to influence brain tryptophan concentration (total tryptophan, free tryptophan, large neutral amino acids) with the concentration of tryptophan in the cortex and CSF were investigated. Tryptophan infusion resulted in plasma tryptophan values comparable to those found after oral doses used in treating depression or insomnia, and about sixfold increases of tryptophan in the cerebral cortex. Increased brain 5-hydroxytryptamine synthesis was indicated by significant rises of CSF 5-hydroxyindoleacetic acid. The concentration of plasma free tryptophan was a better predictor than plasma total tryptophan of cortex tryptophan concentration. As all correlation coefficients of plasma versus brain or plasma versus ventricular CSF tryptophan concentrations were decreased when allowance was made for differences of concentration of large neutral amino acids, the results suggest that the role of these substances within their physiological range as inhibitors of tryptophan transport to the brain may previously have been overemphasised.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb00470.x
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  • 2
    Electronic Resource
    Electronic Resource
    The use of analysis of covariance in the back-calculation of growth in fish (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 24 (1984), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1984.tb04791.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cyclooxygenase 2 (COX2) expression is associated with poor outcome in ER-negative, but not ER-positive, breast cancer (2004)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 45 (2004), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  Inflammation and hormonal signalling induce cyclooxygenase 2 (COX2) expression in solid tumours. COX2 expression is linked to neovascularization and tumour growth. HER2 modulates colorectal cancer COX2 expression. We investigated interactions between COX2 and HER1–4 in breast cancer.Methods and results:  COX2 expression was localized to epithelial cells with 21.2% of cases expressing higher levels than normal epithelium. Elevated COX2 expression was not associated with size, grade, high Nottingham prognostic index (NPI) or oestrogen receptor (ER) negativity. No association was observed between COX2 and HER1–4 expression. High COX2 expression was associated with reduced disease-free survival (P = 0.03) and disease-related survival in ER-negative (P = 0.046) but not ER-positive disease (P = 0.835).Conclusion:  HER1, 2, 3 and 4 are not associated with high breast tumour COX2 expression. COX2 is frequently expressed in breast carcinoma cells and adjacent epithelium. COX2 may be an important factor in promoting tumour progression in ER-negative tumours and a potential drug target in breast tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2004.01898.x
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  • 4
    Electronic Resource
    Electronic Resource
    Rarity of luxotonic responses in cortical visual areas of the cat (1980)
    Springer
    Experimental brain research 39 (1980), S. 125-132 
    Details
    ISSN: 1432-1106
    Keywords: Cat ; Visual cortex ; Luxotonic sustained responses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuronal responses to continuous, diffuse white light or darkness were studied in cortical visual areas 17, 18, 19 and Clare-Bishop of the unanesthetized cat. In contrast to squirrel monkeys and macaques in which about 40 or 25% of the units in striate cortex are luxotonic (response to continuous light or darkness sustained〉2.0 min), all of the visual areas in the cat had fewer than 4.0% of the units exhibiting such luxotonic activity. The functional basis of this difference may be related to differences between the two species in the quantitative balance of antagonistic receptive field properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237544
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  • 5
    Electronic Resource
    Electronic Resource
    Failure to find luxotonic responses for single units in visual cortex of the rabbit (1980)
    Springer
    Experimental brain research 39 (1980), S. 11-16 
    Details
    ISSN: 1432-1106
    Keywords: Visual cortex ; Rabbit ; Primate ; Spontaneous activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The firing frequency of a population of 213 units in striate and circumstriate cortex of the moderately restrained rabbit was studied under the influence of alternating 1-min periods of darkness versus steady, diffuse, featureless illumination. The intent was to determine whether luxotonic responses, so prominent in striate cortex of primates, are indeed absent in rabbits. Such was the case, there being only transient occurrences in three units where the continuing rate of discharge in darkness was double that in the light. There were, however, much more modest differences in rate of continuing discharge in light versus darkness, and for 46% of the units discharging 〉 1/s this difference exceeded 10% and/or 1/s. The rate of discharge in any case did not provide a reliable index as to the characteristics of a unit's receptive field in response to patterned visual stimuli. The nature and function of luxotonic activity in primates still not being understood, it cannot be decided whether its absence in rabbits represents a true qualitative or merely a quantitative difference between species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237064
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  • 6
    Electronic Resource
    Electronic Resource
    Computed tomography in the postoperative patient (1980)
    Springer
    Neuroradiology 19 (1980), S. 257-263 
    Details
    ISSN: 1432-1920
    Keywords: Computed tomography ; Cerebral abscess ; Postoperative patient ; Ring enhancement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nine cases of patients in whom intracranial infection was suspected after operation are presented. Lesions with ring enhancement were seen in all of these patients. The differentiation of enhancement, seen as a normal postoperative phenomenon, from residual neoplasia and cerebral abscess can be difficult. This can be resolved by serial and sequential-delayed CT, and thus unnecessary re-exploration may be prevented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347805
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  • 7
    Electronic Resource
    Electronic Resource
    Driving reaction time after right knee arthroscopy (2000)
    Springer
    Knee surgery, sports traumatology, arthroscopy 8 (2000), S. 89-92 
    Details
    ISSN: 1433-7347
    Keywords: Key words Driving reaction time ; Knee arthroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Notes: Abstract Driving reaction times of 30 right knee arthroscopy patients were measured using a computer-linked car simulator. Each patient was tested pre-operatively and ¶1 week after and 4 weeks after arthroscopy. As controls, 25 normal subjects were also tested. In the control group the average reaction time was 634 ms; the measurements at ¶1 week and at 4 weeks were 550 ms and 582 ms, respectively. In the arthroscopy group the average reaction time pre-operatively was 736 ms; the measurements 1 week and ¶4 weeks post-operatively were 920 ms and 685 ms, respectively. Two clinical tests (the stepping and standing tests) were also performed at each assessment. Statistical analysis showed a good correlation between these and reaction time. We conclude that it is appropriate for patients to delay their return to driving for at least 1 week, and that the actual timing of return to driving may be determined by performance on these two clinical tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001670050192
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  • 8
    Electronic Resource
    Electronic Resource
    Lichenothrix riddlei is an ascolichen and also occurs in New Zealand—light and electron microscopical investigation (1983)
    Springer
    Plant systematics and evolution 143 (1983), S. 293-309 
    Details
    ISSN: 1615-6110
    Keywords: Ascolichens ; Ascomycetes ; Lichenothrix riddlei ; Cyanophyceae ; Scytonema ; Distribution ; anatomy ; fine structure ; Flora of New Zealand
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Lichenothrix riddlei is reported from two widely separate localities in New Zealand. It was previously known only from the South Eastern states of U.S.A. Light and electron microscopy show its sterile fungal partner to belong to the ascomycetes. Apparently as a consequence of lichenization, the variation in breadth of the trichomes of theScytonema phycobiont is greater than normal. A thin, probably gelatinous layer, covering the fungal cells and the algal sheath in the interstices between them, can be demonstrated by electron microscopy. In the contact region with the algal cells, the otherwise two layered wall of the haustoria is reduced to one layer only. In the fungal protoplast conspicuous stacks of ER-like membranes can be found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00986611
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  • 9
    Electronic Resource
    Electronic Resource
    Clostridium difficile and cytotoxin in feces of patients with antimicrobial agent-associated pseudomembranous colitis: Comment on the report by W. L. George et al. (1982)
    Springer
    Infection 10 (1982), S. 208-208 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01666911
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  • 10
    Electronic Resource
    Electronic Resource
    Residential expansion as a continental threat to U.S. coastal ecosystems (2000)
    Springer
    Population and environment 21 (2000), S. 429-468 
    Details
    ISSN: 1573-7810
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Sociology
    Notes: Abstract Spatially extensive analysis of satellite, climate, and census data reveals human-environment interactions of regional or continental concern in the United States. A grid-based principal components analysis of Bureau of Census variables revealed two independent demographic phenomena, α-settlement reflecting traditional human settlement patterns and β-settlement describing relative population growth correlated with recent construction in non-agricultural areas, notably in coastal, desert, and “recreational” counties and around expanding metropolitan areas. Regression tree analysis showed that β-settlement was differentially associated with five distinct combinations of seasonality, summer heat or cool, intensity of agriculture, and extent of “barren” land. Beta-settlement was greatest in coastal and desert areas, and coincided with national concentrations of threatened and endangered species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436749
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