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  • 1990-1994  (1)
  • 1980-1984  (4)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Factors influencing the occurrence of a late reaction to allergen challenge in atopic asthmatics (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 14 (1984), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirty extrinsic asthmatics were challenged by inhalation with Dermatophagoides pteronyssinus extract. In twenty-four an immediate reaction was observed and in sixteen this was followed by a late reaction. Those with late reactions tended to have more severe asthma but did not report greater sensitivity to housedust mite. The occurrence of a late reaction was not related to the degree of airways obstruction before challenge or to the intensity of the immediate reaction. Patients in whom the early reaction was induced by a low dose of inhaled antigen were those most likely to develop a late response. Results of histamine challenge testing suggested that this greater sensitivity of the airway might in part be due to greater non-specific bronchial reactivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1984.tb02211.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Site of airflow obstruction in immediate and late reactions to bronchial challenge with Dermatophagoides pteronyssinum (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 13 (1983), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The density dependence of maximum flow in ten atopic asthmatics was assessed by response to breathing a helium-oxygen mixture. They were then subjected to bronchial challenge by Dermatophagoides pteronyssinus and density dependence re-assessed during early and late bronchial reactions. There was considerable individual variation in the density dependence before challenge and in the change in density dependence during induced bronchospasm. However, for any given individual the results were similar during early and late reactions. This suggests that the major site of airflow obstruction may vary from one asthmatic to another but that when antigen challenge is followed by a dual early and late reaction the site of obstruction is similar at each stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1983.tb02590.x
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Silver retention, total body silver and tissue silver concentrations in argyria associated with exposure to an anti-smoking remedy containing silver acetate (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 5 (1980), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This paper describes a comprehensive study of silver content in a subject suffering from argyria associated with the excessive use of an oral anti-smoking remedy containing silver acetate. Using neutron activation analysis and a radioactive tracer it was possible to measure directly total body silver content, the tendency to retain silver and silver concentrations in various tissues. The findings are discussed in relation to previous knowledge of the disease and indicate that the uptake of silver may be substantial following the use of oral silver preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1980.tb01708.x
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Is prostacyclin a physiologically important circulating anti-platelet agent? (1980)
    [s.l.] : Nature Publishing Group
    Nature 283 (1980), S. 194-195 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Antibodies which neutralise the effects of PGI2 were raised in rabbits using the stable PGI2 analogue 6a,H-5,6-dihydro-PGI2 (PGI1) as the hapten. The preparation of these antibodies and their detailed serological specificity has been reported previously8. The ?-globulin fractions of the immune ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/283194a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Prevention and reversal of experimental colitis by a monoclonal antibody which inhibits leukocyte adherence (1992)
    Springer
    Inflammation 16 (1992), S. 343-354 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of neutrophils in the pathogenesis of acute colitis was investigated using a rabbit model. Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid in 30% ethanol. Myeloperoxidase activity was measured at various times after induction of colitis as an index of neutrophil infiltration, and this was confirmed by histology. The permeability of the colonie epithelium to [51Cr]EDTA was also measured at various times after induction of colitis. The most marked increase in neutrophil infiltration of the colon occurred during the period 3–6 h after induction of colitis. This was also the period in which the greatest increase in colonie permeability was observed. Pretreatment with a monoclonal antibody (IB-4) directed against the leukocyte adhesion molecule, CD18, markedly suppressed neutrophil infiltration into the colonie tissue after induction of colitis. This pretreatment also significantly reduced the extent of epithelial injury. Administration of IB-4 to rabbits 12 h after induction of colitis resulted in a rapid decline in tissue myeloperoxidase activity. When measured 12 h after IB-4 administration (3 mg/kg), colonie myeloperoxidase activity was reduced by about 80% compared to the control group treated with the vehicle. These results are consistent with the hypothesis that neutrophils contribute significantly to the epithelial dysfunction that characterizes colitis and suggest that antibodies directed against adhesion molecules may represent a novel approach to the treatment of intestinal inflammatory disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00917626
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    Paper (German National Licenses)
    Fulltext
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