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  • 1980-1984  (1)
  • 1970-1974  (2)
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  • 1
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 206 (1973), S. 1-10 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein neues Operationsverfahren zur Wiederherstellung des Larynx nach totaler Laryngektomie wurde entwickelt. Die postop. Stimme war ebenso gut wie nach Asais Laryngoplastik. Die Aspiration von Flüssigkeit in die Trachea war nur geringfügig. Das Operationsverfahren des Verfassers ist im folgenden zusammengefaßt: 1. Die lateralen Hälften der Schildknorpelplatten werden auf beiden Seiten belassen; 2. die hintere Larynxwand wird mit Hilfe deroberen Schildknorpelhörner gestaltet; 3. die Innenfläche des wiederaufgebauten Larynx wird mit Stiellappen aus der Hypopharynxschleimhaut gedeckt; 4. der wiederhergestellte Larynx wird am Zungengrund fest vernäht. Dieses Verfahren wurde in 12 Fällen mit ausgedehntem inneren Kehlkopfkrebs durchgeführt. In 3 Fällen trat eine Verzögerung der Heilung durch Entwicklung einer Pharynxfistel nach der Operation ein. Alle Patienten gewannen ihre Stimme und Schluckbewegung wieder.
    Notes: Summary A new procedure is described for the surgical reconstruction of the larynx following total laryngectomy. Postoperatively, the voice was as good as that resulting from the procedure of Asai. Aspiration of fluid into the trachea was minimal. The procedure may be briefly summarized as follows: 1. The lateral portion (about one-half of the total) of both thyroid cartilages are left in situ; 2. a posterior laryngeal wall is fashioned from the superior horns of the same cartilages; 3. the inner surface of the reconstructed larynx is lined by mucosal flaps from the hypopharynx; and 4. the reconstructed larynx is firmly sutured to the base of the tongue. This procedure was employed in twelve cases with extensive internal laryngeal carcinoma. In three of them, healing was retarded by the formation of postoperative pharyngeal fistulae. All patients regained their voices and their abilities to swallow.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In order to clarify the underlying mechanism of malignant transformation from cirrhosis to hepatoma the cell kinetics of hepatocytes were studied in these two conditions. The content and synthesis of DNA in hepatocyte nuclei were investigated, by means of Feulgen-microspectrophotometry and tritiated thymidine radioautography, in cirrhotic and noncancerous parts of hepatoma with concomitant cirrhosis. The distribution of ploidy patterns was widely spread, from hypodiploid to hyperpolyploid, in the noncancerous parts of a cirrhotic liver containing hepatoma. In normal liver, each paired nuclear DNA content of a binucleate cell recorded almost the same amount, whereas in the noncancerous as well as in hepatoma cells much difference of DNA content was observed between the paired nuclei of the binucleate cells. The ploidy pattern of hepatocytes in patients with liver cirrhosis, who had developed hepatoma during follow-up periods of several months to several years, appeared to resemble that in noncancerous parts of hepatoma cases. On the other hand, the incorporation of tritiated thymidine into hepatocytes was found to be markedly increased in noncancerous parts as well as in cirrhotic liver developing hepatoma during follow-up periods. These results suggest the possibility that the hepatocytes in noncancerous parts of hepatoma have deranged cell-kinetics which might be a driving factor for the development of malignancy.
    Type of Medium: Electronic Resource
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