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  • 1
    ISSN: 1432-0428
    Keywords: Chinese hamster ; spontaneous diabetes ; glucosuria ; ketonuria ; glycogen ; glycogen accumulation ; retina ; Müller cell ; kidney ; distal tubule ; pancreatic islet ; a cell ; Β cell ; D cell ; electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracellular glycogen deposits were consistently found in the retina, kidney and pancreatic islets of diabetic-ketonuric Chinese hamsters. Accumulation of glycogen in the outer nuclear layer of the retina was mostly associated with severity of the disease, but was not related to age or sex. The type of retinal cell involved in the accumulation of glycogen was not clearly established. However, the position of the affected cell, side by side with retinal neurons, suggests that the glycogen deposits were within Müller cells. These giant glias normally synthesize and store glycogen. All ketonuric Chinese hamsters examined showed some accumulation of glycogen in distal tubules of the kidney. This abnormal glycogen was not found in glucosuric non-ketonuric or in nondiabetic Chinese hamsters. Variable amounts of glycogen were found inΒ cells of pancreatic islets of diabetic hamsters, as reported by others. However, accumulation of glycogen was also found inα and D islet cells from 2 middle aged Chinese hamsters with long term glucosuria and recent ketonuria. Abnormal glucose and glycogen metabolism seem to play an important role in the pathogenesis of diabetes in the Chinese hamster.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The isolation of synaptic vesicles from mouse brain by a modification of previously reported methodology is described. Homogeneity of the preparations was ascertained by electron microscopy. Vesicles thus isolated contained cyclic AMP (365 ± 44 pmol/mg of protein; mean ± S.E.M.) and adenosine 3′,5′-monophosphate phosphodiesterase activity (500 pmol/mg of protein per 30 min). The number of vesicles in three of the vesicle preparations was determined by a visual count of grid fields under the electron microscope. The content of cyclic AMP in the vesicles was calculated at 5000-7500 molecules/vesiclc. The presence of cyclic AMP in the synaptic vesicles from presynaptic nerve endings would support a role for this nucleotide in nerve transmission.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 10 (1983), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Circulating immune complexes in excess of the equivalent of 20 m̈g/ml heat-aggregated IgG were found in fourteen out of twenty patients diagnosed as having preeclampsia.2. Only six of the nineteen controls tested had similar levels of immune complexes. Recent studies have established that concentrations of heat aggregated IgG in excess of 20 m̈g/ml activate human platelets to release sufficient concentrations of vasoactive agents to constrict a human blood vessel in vitro.3. It is therefore suggested that in vivo platelet activation by circulating immune complexes may release sufficient concentrations of vasoactive agents to contribute to the hypertension in pre-eclampsia.
    Type of Medium: Electronic Resource
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  • 4
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    New York : Periodicals Archive Online (PAO)
    Romanic Review. 61:1 (1970:Feb.) 43 
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 2 (1983), S. 327-334 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bacteroides fragilis grown in the presence of sub-inhibitory concentrations of clindamycin was shown to be altered its degree of encapsulation and susceptibility to phagocytosis by human polymorphonuclear leukocytes. Little polysaccharide capsule could be demonstrated either by light or transmission electron microscopy when the bacteria were grown anaerobically for four hours in the presence of 1/2 MIC of clindamycin. Such clindamycin-grown cells could be opsonized by normal human serum, and although less complement was consumed in the process, were more effectively taken up by the leukocytes than bacteria grown in the absence of the drug (45 % versus 24 %). It was also shown that drug treatment caused significant cellular leakage in the presence of serum, the3H-label appearing extracellularly. In addition there was greater loss of viability of the bacterial cells grown in the presence of the drug and subsequently exposed to the leukocytes for 60 min.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1435-2451
    Keywords: Cytoprotection ; Prostaglandin ; Mucosal blood flow ; Cytoprotektion ; Prostaglandin ; Magendurchblutung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Mechanismus der Cytoprotektion von Prostaglandin (PG) auf die Magenmucosa ist unbekannt. Anaesthesierte Kaninchen erhielten in der Gruppe (GR) I (n=8) im. Aspirin (ASA) (100 mg/kg als Bolus, 66 mg/kg/h kontinuierlich) in der GR 11 (n=10) NaCI und in der GR III (n=7) zusätzlich zum ASA, PGE I (0,1 μg/kg/min) als Infusion über 120 min. Der Mucosa-Blutfluß (MBF) wurde mit radioaktiven Mikrosphären gemessen. In der GR I fiel der MBF nach 15 min um 72,3+3,8% (+ SEM) und nach 120 min um 73,1+3,8% (p 0,05 gegen % Änderung in GR II und III). Nach 120 min zeigte sich in der GR I 19,8 + 7,6% der Fundusmucosa hämorrhagisch, in der GR 11 6,1 +5,2% und in der GR 1112,0+ 1,4% (p 0,05 gegen GR II und III). Wir schließen, daß der cytoprotektive Effekt des PGE I auf einer Aufhebung der ASA bedingten Mucosaischämie beruht.
    Notes: Summary The mechanism by which prostaglandins (PG) exert their cytoprotective effect on the gastric mucosa is not known. Anesthetized rabbits received in Group (GR) I (n = 8) i.v. aspirin (ASA) (100 mg/kg as bolus, 66 mg/kg/h continuously), in GR II (n=10) NaCl and in Gr III PGE I (0.1 μg/kg/min) as an infusion for 120 min. Mucosal blood flow (MBF) was measured with radioactive microspheres. After 15 min, fundus MBF had decreased in GR I by 72.3+3.8% (+SEM) and after 120 min by 73.1+3.8% (P 0.05 vs % change in GR II and III). After 120 min, 19.8+7.6% of the mucosa had become hemorrhagic in GR I, 6.1+5.2% in GR II and 2.0+1.4% in GR III (P 0.05 vs GR II and III). We conclude that the cytoprotective effect of PGE I may be mediated through prevention of ASA-induced mucosal ischemia.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 2 (1982), S. 137-139 
    ISSN: 1437-160X
    Keywords: Rheumatoid vasculitis ; Rheumtoid arthritis ; B8 DR3 phenotype ; Tissue typing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A statistically significant association of clinical rheumatoid vasculitis (excluding nodules or nail-fold infarcts only) with the HLA B8 DR3 phenotype was found when comparing 30 patients with vasculitis with 84 classic or definite rheumatoid patients without clinical vasculitis. The previously reported association on HLA DR4 with rheumatoid disease was also confirmed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 2 (1983), S. 13-17 
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Spontaneous Nasal Septal Perforation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nasal septal perforation is known to be associated with various traumatic and disease states, yet spontaneous nasal septal perforation (SNSP) is relatively rare. SNSP has been reported in three patients with seropositive rheumatoid arthritis (RA) and we report an additional seven patients with SNSP and RA, four of whom were seronegative and none of whom had Raynaud's, in contrast to those reported previously. Manifestations of overt infectious, neoplastic or granulomatous disease have not been found in our seven patients over several years of close follow-up. We have identified no obvious pathogenesis or specific etiology for SNSP. We suggest that SNSP may represent an unusual manifestation of RA previously not well recognized.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 3 (1984), S. 385-387 
    ISSN: 1434-9949
    Keywords: Reactive Arthritis ; Yersinia Enterocolitica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two cases are reported of a reactive arthritis due to infection with Yersinia enterocolitica. These are the fifth and sixth cases reported in the United Kingdom. This interesting cause of arthritis may be more common than previously thought and should be considered even in the United Kingdom, although the practical implications are limited.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Higher education 10 (1981), S. 74-74 
    ISSN: 1573-174X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Nature of Science, Research, Systems of Higher Education, Museum Science
    Type of Medium: Electronic Resource
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