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  • 1
    Digitale Medien
    Digitale Medien
    Massenspectroskopie von Naturstoffen. XV.XIV. Mitt.: VOIGT, D.; JAENECKE G.; R. RICHTER: J. prakt. Chem. 323 (1981) 661; gleichzeitig Teil 84 in der Serie „Gibberelline“. Vergleichende Kationen-Anionen-Massenspektroskopie von Azidogibberellinen (1984)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 326 (1984), S. 187-195 
    Details
    ISSN: 0021-8383
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Mass Spectrometry of Natural Products. XV. Comparative Positive-Negative Ion Mass Spectrometry of AzidogibberellinsThe fragmentation behaviour of 1-azido-3-hydroxy-gibberellin derivatives has been studied by means of positive and negative ion mass spectrometry, high resolution and metastable transitions. The results obtained allow a mass spectrometric distinction to be made between epimers with different stereochemistry of the ring A substituents.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19843260203
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  • 2
    Digitale Medien
    Digitale Medien
    Crystallization, melting, and morphology of low molecular weight polyethylene fractions (1984)
    s.l. : American Chemical Society
    Macromolecules 17 (1984), S. 321-331 
    Details
    ISSN: 1520-5835
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ma00133a011
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  • 3
    Digitale Medien
    Digitale Medien
    New singlets in the phthalocyanines (1981)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 85 (1981), S. 3322-3326 
    Details
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/j150622a023
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  • 4
    Digitale Medien
    Digitale Medien
    Warthin-Finkeldey-like cells in benign and malignant lymphoid proliferations (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 6 (1982), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Multinucleate giant cells resembling Warthin-Finkeldey cells have been described in various lymphoid disorders. These Warthin-Finkeldey-like cells (WFLC) with as many as 50 nuclei are of three main types: reticular, lymphocyte and intermediary. In reactive lymphoid proliferations (34 cases) WFLC were mainly observed inside germinal centres and to a lesser extent in the interfollicular zones. In neoplastic lymphoid proliferations (33 cases) WFLC were most commonly found in the lymphocytic predominance type of Hodgkin's disease (16/25 cases). All non-Hodgkin's lymphomas (13 cases) in which WFLC were detected proved to be of low grade malignancy (lymphocytic: one case, lymphoplasmacytic-plasmacytoid: six cases; and centroblastic-centrocytic, six cases). They were also found in two cases of angioimmunoblastic lymphadenopathy. Immunoperoxidase and electron microscopic studies could not elucidate the exact histogenesis of these cells, but it is assumed that they are associated with B cell proliferations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1982.tb02742.x
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  • 5
    Digitale Medien
    Digitale Medien
    Ultrastructural Study on the Development of Babesia equi (Coccidia: Piroplasmia) in the Salivary Glands of its Vector Ticks (1983)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 30 (1983), S. 0 
    Details
    ISSN: 1550-7408
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: The formation of Babesia equi sporozoites in the salivary glands of three tick species (Hyalomma anatolicum anatolicum, H. a. excavatum, Rhipicephalus turanicus) was studied by electron microscopy. The development was identical in all three vectors. On the 8th day post repletionem kinetes of B. equi had invaded alveoli of the nymphal salivary glands and were transformed to sporonts bounded by a single membrane. The sporonts were polymorphous bodies each with a highly lobed nucleus and numerous mitochondria. These stages persisted during ecdysis of the tick nymph to the adult stage. After attachment of these newly molted adults to a new host the formation of sporozoites was completed within five days. The sporonts occupied most of the infected alveolus and were extensively divided into cytoplasmic portions of various size. On the 4th day after attachment of the tick, sporozoite-anlagen, into each of which a nucleus and a mitochondrion were incorporated, appeared at the periphery of the sporonts. An apical complex with a polar ring, rhoptries, and micronemes was formed at the tip of each protruding anlage. Finally thousands of pyriform sporozoites (3.0 × 1.2 μm) filled the hypertrophied alveolus. This development is similar to sporogony in the genus Theileria.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1550-7408.1983.tb02907.x
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  • 6
    Digitale Medien
    Digitale Medien
    Benzodiazepine Binding to Cultured Human Pituitary Cells (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 43 (1984), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Benzodiazepine receptors were investigated in a cell line of human pituitary cells (18-54,SF) grown in serum-free medium. Preparations of 18–54,SF whole cells and cell membranes were shown to possess satu-rable [3H]diazepam binding sites. Membrane sites were found to have a KD of 20 nM for diazepam while whole cells possessed a twofold higher value. The KD values determined from Rosenthal, Hill, and kinetic analyses were consistent for each preparation. Whole-cell binding of [3H]diazepam was observed to be more stable than binding to membranes at higher temperatures (37°C) and when longer incubation times (60 min) were employed at 4°C. The rank order potency of various benzodiazepines to inhibit [3H]diazepam binding to whole cells and membranes was Ro 5–4864, flunitrazepam, diazepam, and clonazepam. Representatives of other drug classes did not inhibit this benzodiazepine binding. When 18–54,SF cells were grown for 24 h with 100 nM diazepam and then extensively washed membranes prepared, the KD for diazepam increased to 38 nM whereas the Bmax was unchanged when compared with untreated controls. Overall, these findings indicate that pituitary cells possess a peripheral-type benzodiazepine receptor and that the whole cell receptor differs quantitatively when compared with the membrane receptor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1984.tb12850.x
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  • 7
    Digitale Medien
    Digitale Medien
    Response properties of lobster chemoreceptors: tuning of primary taste neurons in walking legs (1984)
    Springer
    Journal of comparative physiology 155 (1984), S. 593-604 
    Details
    ISSN: 1432-1351
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary 1. We determined the tuning properties of 66 single chemoreceptor cells from the legs of the lobsterHomarus americanus. The specificity of these (taste) cells was tested electrophysiologically in the upper range of biologically relevant stimulus concentrations (3×10−4 mol/l) with 15 compounds listed in Table 1. 2. Most of the chemoreceptors surveyed were narrowly tuned to specific test chemicals (Fig. 3). The best stimuli for these chemoreceptors were glutamate (Glu), ammonium chloride (NH4), betaine (Bet) and hydroxyproline (OH-Pro) (Fig. 4). Cell populations were defined by their best stimulus. Populations of cells responding best to Glu and NH4 were extremely narrowly tuned; populations responding best to Bet and OH-Pro were less narrowly tuned (Fig. 5, Table 2). 3. Each cell population showed a range of response specificities, from cells responding to only one compound to cells responding more broadly to other compounds. Within each population cells were arranged by their tuning breadth (H). Cells that shared a best stimulus but responded also to other compounds showed no consistency for the next best stimulus (Fig. 6). This suggests that even cells responding to the same stimulus do not share the same receptor complement. 4. The response patterns to Glu, NH4 and Bet elicited across all the chemoreceptor cells surveyed can be distinguished statistically as different from each other and from all others tested. Similarly, OH-Pro can be distinguished from all other stimuli except glycine and taurine (Figs. 8 and 9). 5. Systematic prior exposure to all 15 test compounds (corresponding to 21 stimulus exposures) at our stimulus concentrations reduced the absolute sensitivity of Glu best cells but did not change the slope of their dose-response functions (Fig. 10) with respect to earlier results (Derby and Atema 1982a). 6. We suggest that extremely narrowly tuned cells in lobster legs may function to detect key compounds as feeding stimuli over a large dynamic range of mixture concentrations such as found in nature. These cells may not be affected as much as broadly tuned cells by ambient backgrounds of cross-adapting compounds. In addition, both narrowly tuned and broadly tuned cells may participate in across fiber patterns to encode the quality of naturally occurring stimulus mixtures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00610845
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  • 8
    Digitale Medien
    Digitale Medien
    Effects of neurotransmitters on the release of corticotropin releasing hormone (CRH) by rat hypothalamic tissue in vitro (1980)
    Springer
    Experimental brain research 39 (1980), S. 229-234 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Hypothalamus in vitro ; CRH ; Neurotransmitters ; Norepinephrine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Effects of neurotransmitters on in vitro release of CRH from rat hypothalamic tissue were investigated. Three whole hypothalami or three mediobasal hypothalami from male rats, adrenalectomized 7 days before, were incubated for 10 min in a medium similar to cerebrospinal fluid at 37 ° C under 95% O2, 5% CO2. CRH activity was assayed by radioimmunological measurement of ACTH released by isolated pituitary cells from adrenalectomized rats. Norepinephrine (NE) at a concentration of 0.02×10−6 M to 2×10−6 M stimulated dose-related CRH release. At larger concentrations the response decreased again (bell-shaped dose-response relationship). The action of norepinephrine was completely blocked by coincubation with phentolamine. Similar results were obtained whether whole hypothalami or mediobasal hypothalami were incubated with norepinephrine. This suggests that the site of action of NE was within the mediobasal hypothalamus. The possibility that the observed effects were due to the CRH-like activity of vasopressin released from the hypothalamic tissue was excluded by simultaneous measurements of CRH activity and arginine-vasopressin concentrations in the medium. Dopamine at very large concentrations (17.6×10−6 M) also stimulated CRH release. Acetylcholine, serotonin, histamine and GABA did not influence the basal CRH release at any of the concentrations tested. These results suggest that in the rat, norepinephrine may have a physiological role as stimulator of CRH-release at the level of the mediobasal hypothalamus. However, in view of the conflicting results obtained with similar and other methods, no definite conclusions should yet be drawn.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00237553
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  • 9
    Digitale Medien
    Digitale Medien
    Enkephalins co-exist with oxytocin and vasopressin in nerve terminals of rat neurohypophysis (1981)
    [s.l.] : Nature Publishing Group
    Nature 289 (1981), S. 502-504 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Neural lobes of five normal white rats and four Brattleboro rats homozygous for hypothalamic diabetes insipidus were fixed with paraformaldehyde and glutaraldehyde and embedded in Epon. Resin was removed from serial 0.5-µm sections and Sternberger's unlabelled antibody-enzyme method applied ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/289502a0
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  • 10
    facet.materialart.
    Unbekannt
    Four Poems (1982)
    Cambridge, Mass. : Periodicals Archive Online (PAO)
    Ploughshares. 8:2/3 (1982) 259 
    Details
    ISSN: 0048-4474
    Thema: Allgemeine und vergleichende Sprach- und Literaturwissenschaft. Indogermanistik. Außereuropäische Sprachen und Literaturen , Anglistik, Amerikanistik
    Notizen: POETRY
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:b238-1982-008-02-000057
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