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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of GABAB Receptor Binding by Guanyl Nucleotides (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 42 (1984), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: GTP and GDP decreased the saturable binding of [3H]baclofen or [3H]γ-aminobutyric acid ([3H]GABA) to GABAB but not GABAA receptors whereas GMP displayed negligible activity. This effect was specific to guanyl nucleotides and was not mimicked by high concentrations of ATP. The inhibition of ligand binding was the result of a diminished receptor affinity with no change in receptor number. The use of a complete physiological saline solution rather than Tris buffer plus Ca2+ or Mg2+ increased the potency of GTP at the GABAB receptor. The results are discussed in relation to the effects of GABA and GTP on adenylate cyclase activity in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1984.tb02732.x
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of the complex-dissociation model for free-radical copolymerization (1983)
    s.l. : American Chemical Society
    Macromolecules 16 (1983), S. 1295-1300 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00242a008
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  • 3
    Electronic Resource
    Electronic Resource
    Analysis of the mechanism of copolymerization of styrene and acrylonitrile (1982)
    s.l. : American Chemical Society
    Macromolecules 15 (1982), S. 960-966 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00232a004
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  • 4
    Electronic Resource
    Electronic Resource
    Movement of fluometuron, simazine, 36Cl− and 144Ce3+ in soil under field conditions: qualitative aspects (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Weed research 21 (1981), S. 0 
    Details
    ISSN: 1365-3180
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The distributions of two herbicides and two radioactive ions in field plots at two sites were determined at periods up to 187 days following surface applications in the spring. The results demonstrated the variability characteristic of field situations. At one site some fluometuron moved a short distance down the profile but after 187 days most remained above 6 cm whereas at the other site there was essentially no movement below 3 cm. At both sites simazine was almost entirely confined to the top 3 cm. The adsorption characteristics of the two compounds are similar so the greater mobility of fluometuron is probably a consequence of its greater solubility, Measurements of 36Cl− indicated a significant movement of water through the 30 cm depth studied. 144Ce3+ used as a tracer of soil particles was of similar mobility to simazine.In general the movement of chloride and the two herbicides can be interpreted in terms of the concept of mobile and immobile fractions of soil water in which a proportion of the mobile water does not reach equilibrium with solutes in the bulk of the soil. Soil structural effects may therefore be more important than adsorption in controlling the movement of solutes and redistribution in association with soil particles can be significant. A parallel laboratory experiment showed that the results from a standard leaching column procedure did not necessarily indicate field performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3180.1981.tb00130.x
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  • 5
    Electronic Resource
    Electronic Resource
    Movement of fluometuron and 36Cl− in soil under field conditions: computer simulations (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Weed research 22 (1982), S. 0 
    Details
    ISSN: 1365-3180
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The movement of chloride ion and the movement and degradation of fluometuron in two soils of contrasting texture and structure was predicted with a simulation model which included terms for the degradation of fluometuron as a function of temperature and moisture. The simulated distributions of soil water, chloride ion and fluometuron were compared with the observations reported in a previous paper (Hance, Embling, Hill, Graham-Boyce & Nicholls, 1981), Soil waler contents and fluometuron distribution were simulated reasonably accurately. Movement of chloride to below 30 cm in both soils and degradation of fluometuron in the WRO sandy loam soil were not well simulated. The discrepancies between observed and predicted water contents and chloride distribution show the importance of measuring dynamic as well as static water properties. Therefore refined simulation models may need to account for pore continuity, soil particle movement and mobile and immobile categories of water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3180.1982.tb00173.x
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  • 6
    Electronic Resource
    Electronic Resource
    Cross-reactivity between Acacia (wattle) and rye grass pollen allergens (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 12 (1982), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunoglobulin E (IgE), directed against components of Acacia (wattle) pollen, has been detected by radioallergosorbent tests (RAST) in the sera of some children and adults who develop allergic symptoms in the presence of flowering Acacia trees in Australia. All these subjects also had high levels of IgE directed against Lolium perenne (rye grass) pollen. Inhibition by RAST showed that most of the IgE molecules which bound to Acacia pollen components also bound to L. perenne pollen extracts, and to Glycoprotein I, the major allergen of L. perenne pollen. In these assays, the allergens have been immobilized on polyvinyl chloride microtitre trays: the sensitivity of this approach is compared to that of commercial RAST kits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1982.tb02526.x
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  • 7
    Electronic Resource
    Electronic Resource
    Predicting the results of allergen bronchial challenge by simple clinical methods (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 12 (1982), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this study, the ability to predict allergenic bronchial reactivity from non-specific bronchial reactivity, measured by free corridor-running, and the level of skin reactivity to whole rye grass pollen extract (WRGPE–Lolium perene) and house-dust mite extract (HDM–Dermatophagoides pteronyssinus) was examined in asthmatic children. Discriminant analysis of the data showed that, for the concentration of extracts used and the conditions of bronchial challenge for both allergens, the level of skin sensitivity to undiluted extract and the percentage fall in peak flow-rate on exercise best-predicted the outcome of bronchial challenge for WRGPE (100% of cases) and for HDM (89% of cases).The results suggest that it may be possible to predict allergenic bronchial-reactivity to different allergens in children by simple clinical methods, if conditions of provocation and potency of allergen extracts can be standardized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1982.tb02531.x
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  • 8
    Electronic Resource
    Electronic Resource
    Cow's milk allergy and eczema: patterns of the antibody response to cow's milk in allergic skin disease (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 12 (1982), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pattern of the humoral-immune response to cow's milk was examined in children with eczema and in children who had acute urticarial and/or angioedematous reactions to cow's milk. Each patient group was compared to a group of age-matched controls.Whereas the eczematous patients had significantly elevated IgG, IgA and IgE milk-antibodies, patients, allergic to cow's milk, had elevated IgE milk-antibodies. These differences in the pattern of antibody response to cow's milk suggests that these two patient groups constitute separate allergic populations, and that different pathogenic mechanisms may be operative in these two skin diseases associated with elevated levels of IgE antibodies to cow's milk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1982.tb02543.x
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  • 9
    Electronic Resource
    Electronic Resource
    Specific cellular and humoral immunity in children with grass pollen asthma (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 12 (1982), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymphocyte stimulation, as determined by incorporation of thymidine, to rye grass extract in twenty-three children with bronchial reactivity to rye grass and to house dust mite, did not differ significantly from four children with reactivity to house dust mite alone, or from nine children with asthma but without a bronchial response to these allergens. Sixteen children underwent hyposensitization with rye grass extract or treatment with placebo. There was no consistent effect of hyposensitization on the lymphocyte stimulation indices to rye grass. A decrease in lymphocyte responsiveness occurred to rye grass and to house dust mite after the grass pollen season but was not statistically significant. Analysis of changes in lymphocyte responsiveness to both house dust mite and rye grass of the children most highly sensitized to rye allergen, showed that the lymphocyte responsiveness to rye grass fell during the pollen season (P〈0.05) but this effect was not seen with house dust mite. The study suggests that a decrease in lymphocyte responsiveness to rye grass allergen in children with large amounts of anti-rye IgE antibodies is antigen specific and may be seen following seasonal exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1982.tb03129.x
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  • 10
    Electronic Resource
    Electronic Resource
    Immunoglobulin E antibodies to ingested cereal flour components: studies with sera from subjects with asthma and eczema (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 12 (1982), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The specificity of immunoglobulin E for different cereal grain proteins was investigated using sera from twenty paedialric patients with asthma and/or eczema. Close correlations were observed between radioallergosorbent test values for grain extracts of wheat, rye and barley, and, to a lesser extent, oats. Of the different wheat flour fractions tested, the globulins and glutenins consistently bound higher levels of IgE than the gliadins and albumins. This is in contrast both with bakers' asthma (an allergy to inhaled flour where the albumins are important allergens) and with coeliac disease (in which gliadin is the most toxic fraction). Partial digestion of the flour proteins largely removed their ability to bind IgE, An analytical technique of identifying allergens after gel isoelectric focusing demonstrated that many different flour proteins were involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1982.tb03127.x
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