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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 143 (1984), S. 35-40 
    ISSN: 1432-1076
    Keywords: Chronic intrahepatic cholestasis ; Biliary lipid composition ; Bile acids ; Gallstones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Biliary lipid composition, standard liver function tests, serum lipids and faecal fat excretion were studied in 15 children with chronic intrahepatic cholestasis (severe intrahepatic cholestasis, n=6; paucity of intralobular bile ducts, n=4; benign recurrent cholestasis, n=5) and compared to 15 children without gastrointestinal diseases. Severe and benign intrahepatic cholestasis were associated with normal or moderately elevated serum lipids. Biliary lipid concentrations were extremely reduced, bile acid concentrations were below the critical micellar concentration. This may account for the high incidence of gallstone formation in these patients. Remission periods in patients with benign recurrent cholestasis were not followed by complete normalisation of biliary lipid concentrations, indicating a primary defect in hepatic excretory function. Children with paucity of intralobular bile ducts showed markedly increased serum lipids, but only a two-fold reduction in biliary lipid concentrations. Cholic acid was the predominant bile acid in bile of all cholestatic children even during remission. Neither increased levels of monohydroxy bile acids nor unusual bile acids could be identified in notable amounts.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 143 (1984), S. 41-44 
    ISSN: 1432-1076
    Keywords: Chronic intrahepatic cholestasis ; Biliary lipid composition ; Bile acids ; Phenobarbital
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of phenobarbital (5.4–7.5 mg/kg body weight) for 14 days were studied in four children with severe intrahepatic cholestasis (group I) and in four with a syndromatic type of paucity of intralobular bile ducts (group II). Phenobarbital administration resulted in a moderate improvement of pruritus in all patients. There was a significant decrease of bilirubin in serum (group I: from 4.8 to 2.7 mg/dl; group II: from 6.1 to 2.1 mg/dl); total bile acids (group I: from 416 to 337 μmol/l; group II: from 156 to 123 μmol/l) and cholesterol (group I: from 248 to 207 mg/dl; group II: from 351 to 292 mg/dl). Alkaline phosphatase activity increased from 929 to 1126 U/l in group I and from 1751 to 2360 U/l in group II. SGOT and SGPT activities remained unchanged in both groups. In group I total biliary lipid concentration and bile acid output increased from 0.09 to 0.17 g/dl and from 3.9 to 7.2 μmol/kg per 30 min, respectively. Molar percentages of cholesterol, phospholipids and bile acids in bile remained unchanged. In group II total lipid concentrations and bile acid output increased from 1.62 to 2.0 g/dl and from 27.8 to 39.1 μmol/kg per 30 min, respectively. The molar percentage of cholesterol decreased from 5.6 to 3.5 mol%. The present results indicate that short term administration of phenobarbital has only minimal effects on biliary lipid metabolism in children with chronic intrahepatic cholestasis.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 13 (1983), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Precipitins against avian antigens in sera from patients with extrinsic allergic alveolitis, asymptomatic pigeon and chicken breeders and from control individuals were tested with different antigen extracts in six laboratories by a variety of different methods. Eighty percent of the results coincided in identifying the positive sera from patients and 90% in identifying the controls. It seems possible therefore to exchange results among experienced laboratories with fair confidence.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 409 (1983), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 354 (1981), S. 273-279 
    ISSN: 1435-2451
    Keywords: Duodenogastric reflux ; Quantification ; Gastric resection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der duoenogastrische Reflux wurde quantitativ bei den klassischen Magenresektionsverfahren (Billroth II — mit und ohne Enteroanastomose, Billroth I), sowie bei Magengesunden bestimmt. Insgesamt wurden 43 Magenresezierte und 6 Magengesunde untersucht. Die B II-Resezierten ohne Braunsche Enteroanastomose (n = 10) wiesen einen Reflux von 50,4 ± 4,1 % (SEM) der während der Untersuchung sezernierten Gallenmenge auf. Bei den B II-Resezierten mit Braunscher Enteroanastomose (n = 15) betrug der Reflux 21,5 ± 3,7 % (SEM), bei den B I-Resezierten (n =17) 23,1 ± 3,5 (SEM). Die magengesunden Kontrollpersonen (n = 6) wiesen einen Reflux von 0,5 ± 0,4% (SEM) auf.
    Notes: Summary The duodenogastric reflux was measured quantitatively in patients with classic gastric resections (Billroth I, Billroth II with and without enteroanastomosis) as well as in patients without gastric operations. A total of 43 patients with gastric resection and 6 without gastric operation were studied. Patients operated according to B II without Braun's enteroanastomosis (n = 10) had a bile reflux of 50.4 ± 4.1 % (SEM) during the study. Patients having been operated according to B II- with Braun's-enteroanastomosis (n = 15) and those having undergone B I-operation (n = 17) had a duodenogastric reflux of 21.5 ± 3.7 % (SEM) and 23.1 ± 3.5 % (SEM), respectively. In 6 control subjects without gastric operation bile reflux into the stomach averaged 0.5 ± 0.4 % (SEM).
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 238 (1983), S. 77-85 
    ISSN: 1434-4726
    Keywords: Total activity of LDH ; Perilymph ; Sources of error and purity testing ; Plasma ; Cerebrospinal fluid ; Guinea pig ; Noise exposure ; LDH-Gesamtaktivität ; Perilymphe ; Fehlerquellen und Reinheitskontrolle ; Plasma ; Liquor cerebrospinalis ; Meerschweinchen ; Schallbelastung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Gesamtaktivität der Laktatdehydrogenase (LDH) von Perilymphe (PL) der Scala tympani und Scala vestibuli, arteriellem Blutplasma und Liquor cerebrospinalis (CSF) unbelasteter und schallbelasteter Meerschweinchen wurde unter besonderer Berücksichtigung der wesentlichen Fehlerquellen untersucht. Zur Reinheitskontrolle der PL-Proben dienten simultane Protein- und Elektrolytbestimmungen (Tabelle 1). Die LDH-Aktivität wurde fluorimetrisch bestimmt. Es zeigte sich, daß zwischen PL, CSF und Plasma erhebliche LDH-Aktivitätsunterschiede bestehen (Tabelle 2). Die mittlere Aktivität ist in der PL 3–4mal höher als im CSF und nur etwa halb so hoch wie im Plasma. Zwischen PL der Scala tympani und Scala vestibuli ergab sich kein signifikanter Unterschied. Die häufigsten LDH-Werte der einzelnen Flüssigkeiten (Abb. 2) liegen etwas unter den arithmetischen Mittelwerten. Unmittelbar (≤60 min) nach 10minütiger Breitbandbelastung mit 140 dB SPL lagen die Mittelwerte der PL beider Schneckenskalen etwas höher als beim unbelasteten Tier (Tabelle 3). 18 h nach Belastungsende zeigte sich nur in der PL der Scala vestibuli eine etwas höhere Aktivität. Die Unterschiede konnten statistisch nicht gesichert werden. Die LDH-Werte von CSF und Plasma blieben sowohl ≤60 min als auch 18 h nach Schallbelastung unverändert.
    Notes: Summary The total activity of lactate dehydrogenase (LDH) of perilymph (PL), plasma, and cerebrospinal fluid (CSF) of unexposed and sound-exposed guinea pigs was examined with due consideration of the principal sources of error. To test the purity of PL samples, protein, potassium, and sodium were determined simultaneously (Table 1). The LDH was analysed fluorometrically. It was found that there are considerable differences in the LDH activities of PL, CSF, and plasma (Table 2). The mean activity of PL was three to four times higher than that of CSF and only about half that of plasma. No significant difference was found between the PL in scala tympani and scala vestibuli. The most frequent LDH values of the individual fluids (Fig. 2) were somewhat lower than the mean values calculated. Immediately (≤60 min) after exposing the animals to wide-band noise at an intensity of 140 dB SPL for 10 min, the mean PL values of the scala tympani and scala vestibuli were found to be somewhat higher than in unexposed animals (Table 3). Eighteen hours after the exposure, slightly higher activity was only detectable in PL of the scala vestibuli. The differences were not found to be significant. The LDH values of CSF and plasma remained unchanged both ≤60 min and 18 h after noise exposure.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 240 (1984), S. 43-48 
    ISSN: 1434-4726
    Keywords: Biochemical analysis ; Perilymph ; Sources of error ; Cerebrospinal fluid ; Guinea-pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Contamination of perilymph with other fluids (cerebrospinal fluid, tissue fluid, blood, endolymph) together with sampling, anaesthesia, surgical intervention or food intake of the animals may considerably affect the analytical result. The numerous possible artefacts seem to be the main reason why varying values are given in the literature for the same chemical component of perilymph. This is also partly true of cerebrospinal fluid and blood. The effect of some sources of error on selected chemical components of perilymph, cerebrospinal fluid and blood is briefly summarized.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 471-471 
    ISSN: 1435-2451
    Keywords: Ileal resection ; Biliary secretion ; Cholesterol gallstone formation ; Ileumresektion ; biliäre Sekretion ; Cholesteringallensteinbildung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Patienten mit Resektion des terminalen Ileums weisen eine erhöhte Incidenz von Cholesteringallensteinen auf. Zur Aufklärung des Mechanismus der Steinbildung wurde bei 5 Patienten mit Ileumresektion (mehr als 120 cm) und bei 5 Kontrollpersonen die biliäre Lipidsekretion über 24 h gemessen. Die biliäre Sekretion von Gallensäuren (GS), Phospholipiden (PL) und Cholesterin (CH) war bei den resezierten Patienten um 52 %, 53 % bzw. 47 % erniedrigt. Die Reduktion der CH-Sekretion war nicht so ausgeprägt wie die von GS und PL. Aus diesem Grunde war die Galle bei Ileumresezierten 14 h am Tag mit CH übersättigt, im Gegensatz zu 7h bei den Kontrollpersonen (p 〈 0,0s1).
    Notes: Summary Patients with resection of the ileum are at increased risk of forming cholesterol gallstones. In order to investigate the underlying mechanism of stone formation, biliary lipid secretion was measured for 24 h in five patients after ileal resection (more than 120 cm) and five controls. The biliary secretion of bile acid (BA), phospholipids (PL), and cholesterol (CH) in ileal resected patients was reduced by 52%, 53%, and 47%, respectively. The reduction in cholesterol secretion rate was not as much as that of BA and Pl. As a result, the bile in patients with ideal resection was supersaturated with CH for 14h in contrast to 7 h in control subjects (p 〈 0.01).
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-1536
    Keywords: Proton-NMR ; spin-spin-relaxation ; lineshape analysis ; multicomponent polimeric systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Abstract A method is presented to study the proton spin-spin-relaxation of one and two phase polymeric systems in a time range of 10−6 to 10−1 s, using a logarithmic time scale. Observing the line shape of the free induction decay (FID), an extensive description of the relaxation behaviour is possible in case of one phase systems in the temperature range from the rigid solid to the melt, and in case of two phase systems (in the temperature range between the glass temperatures of each phase) for each phase separately. By a combination of serveral pulse methods known from the literature, the true shape of the FID's is measured. The FID's are analyzed by comparison with simple mathematical line shapes. Several examples of measurements and analyses are discussed.
    Notes: Zusammenfassung Als Grundlage von Polymeruntersuchungen wird ein Meßverfahren vorgestellt, das die Beobachtung der Protonen-Spin-Spin-Relaxation von Ein- und Zweiphasensy steinen in einem Zeitbereich von 10−6 bis 10−1 s unter Verwendung einer logarithmischen Zeitachse gestattet. Hierdurch wird eine einwandfreie Kennzeichnung der Einphasensysteme hinsichtlich der Kettenbeweglichkeit vom Festbis in den Schmelzzustand und der Zweiphasensysteme für jede Phase separat ermöglicht. Durch die Kombination einer Reihe von in der Literatur beschriebener Meßverfahren werden Störeffekte, die die Relaxationskurve verzerren, ausgeschaltet. Die gemessenen Relaxationskurven werden durch Vergleich mit geeigneten Kurvenprofilen mathematisch analysiert. Einige Anwendungsbeispiele werden diskutiert.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 258 (1980), S. 24-26 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Zusammenfassung Es wird eine Schnellmeßmethode zur Bestimmung des Protonenanteils und der Spin-Spin-Relaxationszeit der molekular beweglichen Phase von zweiphasigen Polymeren beschrieben, die für einen Temperaturbereich gilt, in dem die eine Phase (Hartphase) unbeweglich und die andere Phase (Weichphase) beweglich ist. Die Methode beruht auf dem Magnetisierungsabfall (FID), der einem 90°-Impuls folgt. Sie ist nicht auf partiell-kristalline Polymere anwendbar.
    Notes: Summary A rapid method is described to measure the proton fraction and the spin spin relaxation time of the mobile phase of two-phase polymers in a temperature range where one phase is rigid (hard phase) and the other shows molecular motion (soft phase). The method is based on the free induction decay (FID), following a 90°-pulse. It is not suitable to partially crystalline polymers.
    Type of Medium: Electronic Resource
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