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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 42 (1981), S. 383-391 
    ISSN: 1432-1106
    Keywords: Harmaline ; Tremor ; Interposito ; Rubral system ; Oculomotricity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Units were recorded extracellulary in the cat brainstem under the effect of tremogenic doses of harmaline. They were localized post mortem and the units discharging at the harmaline tremor frequency were mapped. Harmaline-sensitive neurons were found in the bulbo-pontine reticular formation, in particular, in the lateral reticular nucleus and the nucleus reticularis tegmenti pontis. The nucleus interpositus as well as the red nucleus also displayed numerous units discharging at the tremor frequency, indicating that the cerebello-interposito-rubro-spinal system controlling the flexor muscles participate in harmaline tremor. Participation of the oculomotor system in the harmaline-induced tremor was tested at the level of the vestibular neurons relaying the vestibulo-ocular reflex, the motoneurons, the eye muscles and the eye movements. No rhythmic discharge at the tremor frequency nor eye movements could be detected, indicating that harmaline tremor does not affect the oculomotor system.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1106
    Keywords: Harmaline tremor ; Cerebellum ; Inferior olive ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Purkinje cells were recorded extracellularly and mapped in the cerebellar cortex of the rat under tremogenic doses of harmaline. Four différent types of responses were encountered, of which two were considered as being responsible for the harmaline tremor. The latter had a regular firing pattern of complex spikes at 5 to 10 Hz and were mostly found in the vermis. Their number decreased in the more lateral region of the cerebellar cortex until they eventually disappeared. Horseradish peroxidase was injected into all the areas of the cerebellar cortex containing Purkinje cells with harmaline-induced activity. Labeled neurons were in all cases traced to the medial accessory olive. The metabolic activity of the inferior olive under harmaline was measured with 2-deoxyglucose. Increased labeling was only found in the medial accessory olive. Such an increase was demonstrated as being due to a direct effect of the drug on the inferior olivary neurons, indicating that the medial accessory olive is responsible for the harmaline tremor in the rat. Our results point out that, in the rat, there is an inverse relationship between serotoninergic innervation of a region in the inferior olivary nucleus and that with harmaline sensitivity, therefore a serotoninergic mechanism hypothesis for the harmaline tremor needs further investigation.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1106
    Keywords: Cerebellum ; Fastigial nucleus, [14C]-2-deoxyglucose ; Unit activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cerebellar output function was studied using cerebellopetal proprioceptive stimulation hich produces simple and complex excitatory discharges as well as inhibitory activity in the Purkinje cells. The activity of the intracerebellar nuclei (and of the entire brain stem) was measured by the energy consumption as revealed with the [14C]-2-deoxyglucose method. The stimulations consisted of repetitive (1–20 c/s) electrical excitation of the nerve leading to the inferior oblique, to the masseteric and to the gastrocnemius soleus muscle. Compared to a group of non-stimulated controls, heavy bilateral labeling was obtained in the posterior pole of the fastigial nucleus. This was not observed with stimulation of the vibrissal pad which, however, produced a clear increase of [14C]-2-deoxy glucose uptake in the secondary trigeminal complex. Labeling of the posterior part of the fastigial nuclei was suppressed by ablation or pharmacologic inactivation of the overlying cerebellar cortex which suppresses the inhibitory activity of the Purkinje cells into the nuclear cells. Labeling of the posterior fastigial nuclei was also decreased in animals not stimulated but with ablation or pharmacologic inactivation of the overlying cerebellar ortex. The hypothesis proposed is that the marking results are the consequence of an increased activity in the Purkinje cell terminals. The activity of the Purkinje cells was also recorded extracellulary both before and during repetitive stimulation of a muscle nerve. The discharge activity of those in the cerebellar vermis and giving axons to the posterior fastigial nucleus was increased by the stimulation, whereas the activity of those of the hemispheral parts remained unchanged. Units in the fastigial nucleus were also recorded. Their activity was found to be deeply depressed so that only a few units were encountered and no further decrease of their discharge could be detected with the stimulation of a muscle nerve. Nevertheless, using the present data and those previously obtained, the conclusion is advanced that the cerebellar output function is actually decreased during afferent cerebellar stimulation.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1076
    Keywords: Wilms' tumor ; Translocation-position effect ; Child ; Malformative syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An apparently balanced de novo constitutional translocation (7;13) (q36;q13) was detected on peripheral lymphocytes and fibroblasts of a 14-month-old boy. The patient presented a facial dysmorphism with hydrocephaly and mental retardation associated with a Wilms' tumor. A pure coincidence of random association cannot be ruled out but one can equally assert the plausibility of a minimal unnoticed deletion or a position effect.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Human communication research 8 (1981), S. 0 
    ISSN: 1468-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Media Resources and Communication Sciences, Journalism
    Notes: During the second half of the past decade, psycholinguistic models of speech production have been modified to include a “prearticulatory editing” component, the supposed function of which is to verify the linguistic integrity of impending phoneme strings destined for articulation. Empirical support for psycholinguistic editing comes primarily from studies by the present authors on laboratory-induced verbal slips. All of these studies have depended upon two crucial claims: that laboratory slips are errors of output, and that error-rate differentials are evidence of editing. Recently, however, it has been recognized that neither of these assumptions has been convincingly demonstrated, and consequently the editing models instigated by the earlier studies are being reassessed. The present study tested these two assumptions directly. The output-error assumption was supported by finding larger Galvanic Skin Resistance (GSR) responses for verbal slips than for correct vocalizations. The editing assumption was supported by finding that presumably edited vocal responses (identified by GSR) require more processing time (i.e., vocal response latency) than unedited responses. The reasoning from the empirical observations to conclusions about these assumptions is discussed in detail. Secondarily, a hypothesized social acceptability editing criterion was supported by the observation that neutral verbal slips outnumber taboo counterparts.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Human communication research 8 (1982), S. 0 
    ISSN: 1468-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Media Resources and Communication Sciences, Journalism
    Notes: Three competing models of word recognition processes currently receive psycholinguistic research support: direct encoding (i.e., word recognition proceeds from graphemes); indirect encoding (i.e., word recognition proceeds from a phonemic translation of graphemes); and dual access (i.e., word recognition can proceed from either graphemes or phonemes). Resolution of the conflict between these models has been hampered by methodological problems common to research techniques in this area. The two experiments reported in this study analyzes the competing models via the SLIP technique, which avoids those methodological problems. Support is yielded for the direct encoding model. Implications are discussed.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1752-0606
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: Client acceptability of treatment procedures has recently become a significant concern in the assessment of psychotherapeutic effectiveness (Kazdin, French & Sherick, 1981; Wolf, 1978). Formally, acceptability refers to the fairness, appropriateness and intrusiveness of the treatment procedure as judged by clients, lay persons and nonprofessionals (Kazdin, 1980a). Unfortunately, marital and family therapists have yet to utilize this criterion in an evaluation of their psychotherapeutic interventions. Consequently, the purpose of the present investigation was to examine the acceptability of four differing therapeutic models (psychoanalytic, behavioral, systems and eclectic) used in the treatment of marital discord.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 11 (1984), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of advanced nursing 5 (1980), S. 0 
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study utilizes four outcome measures to compare the success of a home nursing programme on a group of patients previously hospitalized and a non-hospitalized group. The outcome measures are: mortality, stabilization, hospitalization and nursing home confinement at discharge from the programme. No significant differences were found between the groups, except for nursing home confinement which was higher for the non-hospitalized group. The relationships remained the same even when age and functional status were considered as alternative hypotheses. Implications of this study suggest that home nursing programmes are likely to be as successful with previously hospitalized, as they are with non-hospitalized, patients. Secondly, in evaluating the impact of home nursing programmes on patients, the potential stabilizing influence of the hospital must be taken into account before examining the programme in isolation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 28 (1981), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Variations in the cathodoluminescent properties of carbonates are usually attributed to differing proportions of manganese (Mn2+) as the most important activator, and iron (Fe2+) as the main inhibitor of luminescence. Interactions between manganese and iron concentrations and the luminescent properties of dolomite are demonstrated by petrographic and chemical analyses of 86 samples of dolomite representing a range of depositional environments and ages (Cambrian to Cretaceous) and a wide geographical distribution (North America and Europe).Iron and manganese are positively correlated in the dolomites, with the former showing a greater range of variation. Very small amounts of manganese are sufficient to activate the luminescence and as little as 100 ppm Mn2+ is present in highly luminescing samples. The intensity of luminescence is not proportional to the manganese concentration. Iron begins to quench luminescence as its concentration reaches 10,000 ppm. Above that level, luminescence is rapidly lost and total extinction occurs among samples containing more than 15,000 ppm Fe2+, regardless of the manganese concentration.
    Type of Medium: Electronic Resource
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