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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 59 (1981), S. 5-18 
    ISSN: 1432-1440
    Keywords: Osteoporosis ; Bone marrow histology ; Bone marrow microcirculation ; Osteogenesis ; Osteoporose ; Knochenmarks-Histobiopsie ; Knochenmarksmikrozirkulation ; Osteogenese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Obgleich ihre Folgen ein wohlbekanntes klinisches Syndrom darstellen und obgleich eine Fülle von biochemischen, radiologischen und nuklearmedizinischen Untersuchungen über ihre Entstehung vorliegt, ist die Pathogenese der sogenannten primären Osteoporose noch immer unbekannt. Anhand von histobioptischen Beobachtungen an 1727 Kranken mit „idiopathischer“ und 288 Kranken mit sekundärer Osteoporose wird ein struktureller Zusammenhang von Veränderungen der Knochenmarkskapillaren und dem Schwund des trabekulären Knochens bei diesen Störungen gezeigt. Eine neue Hypothese über die strukturelle und funktionelle Rolle der Knochenmarkskapillaren sowohl bei normalem als auch bei krankhaftem Knochenumbau stützt sich auf die vorgelegte vergleichende morphometrische semiquantitative Analyse von Normalfällen einerseits, von hypo- und hyperplastischen Veränderungen der Mark- und Knochengewebe bei verschiedenen hämatologischen und osteologischen Krankheiten andererseits. Die bessere Kenntnis dieser Zusammenhänge und ihrer hormonellen und nervösen Grundlagen könnte einen neuen Weg zum Verständnis und zur kausalen Behandlung der sogenannten „idiopathischen“ Osteoporose eröffnen.
    Notes: Summary In spite of a well defined clinical syndrome and a wealth of biochemical information, the pathogenesis of primary osteoporosis is still uncertain. Microscopic evaluation of semithin sections of 1727 bone biopsies from patients suffering from “idiopathic” osteoporosis and 288 from patients with secondary osteoporosis has lead to the recognition of a pathogenetic relationship between changes of the bone marrow capillaries and atrophy of the trabecular bone in these groups. A new hypothesis is proposed for the structural and functional role of the bone marrow capillaries in normal and abnormal osseous remodelling; this is based on comparative morphometric analysis of normal cases and of hypo- and hyperplastic changes of the myelogenous and osseous tissues in various haematological and bone disorders. The hormonal and nervous regulation of the microcirculation of the bone marrow may offer a new approach to the understanding and cure of so-called idiopathic osteoporosis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 1326-1326 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 541-542 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 59 (1981), S. 148-148 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 20 (1981), S. 311-319 
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archiv der Mathematik 35 (1980), S. 501-504 
    ISSN: 1420-8938
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 286 (1980), S. 187-188 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] JUST as it was once common in natural history to view a wide array of species as existing primarily for the benefit of man, so too was it once common in the history of science to consider a large number of scientists as being adequately understood once they were identified as the 'precursors' of ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 8 (1982), S. 169-178 
    ISSN: 1432-2161
    Keywords: Bone biopsy ; Bone marrow ; Bone remodelling, Carcinoma ; Metastatic cancer ; Osteodysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cancellous bone of the skeleton usually shows striking alterations when metastatic carcinoma has involved the bone marrow. These changes, termed carcinomatous osteodysplasia (COD), have been analyzed in 1164 iliac crest biopsies of unselected patients with a variety of primary tumours. Semithin (3 μ) sections of undecalcified biopsies embedded in methacrylate were examined for foreign cells. Metastases were found in 462 of the 1164 biopsies and 91% of these, as well as 17% of the negative biopsies, showed some degree of COD. Osteodysplasia was more frequent in biopsies of patients with signs of systemic spread than in those without. COD includes a variable, local increase in active osteoblasts and osteoclasts, in blood vessels and in other stromal tissues. The incidence of COD was higher in the adenomatous and scirrhous metastases than in the other histological varieties. COD was subdivided into primarily osteolytic, osteosclerotic, and mixed types, and five different forms of bone resorption and formation were identified. These forms showed a characteristic association with the degree of mesenchymal activation on the one hand and the structural type of the metastases on the other, and correlated with certain cytological characteristics of the neoplastic cells. We conclude that COD is a significant consequence of the biological activities of metastatic cancer and it is readily accesible for observation by bone biopsy. The morphological classification of COD proposed in this study provides a basis for further investigation.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bone marrow biopsy of the iliac crest was performed on 268 patients (124♂; 144♀). Of these patients 206 had haematological systemic disorders (HSD) or carcinoma and suspected bone involvement, which was confirmed by biopsy on 66 patients. Bone biopsy was performed not longer than 3 weeks after X-ray examination and bone scintigraphy which, combined, had already raised the suspicion of skeletal involvement in 55% of the 66 patients with skeletal involvement diagnosed by biopsy. Additional quantitative evaluation of the bone scans using bone to soft tissue ratios was able to increase the overall accuracy to 67% in that group. Additional quantitative assessment of the scan yielded considerably more effective bone scintigraphy, particularly in cases with visually normal patterns. Available equipment should therefore be used in scintigraphic bone imaging on a routine basis. It was shown that the various methods of examination, i.e. X-ray, biopsy and scintigraphy with both visual and quantitative evaluation provide their own individual values for the final diagnosis. Therefore, if one of the methods shows a negative result, bone involvement is not excluded and the others should be used for confirmation.
    Type of Medium: Electronic Resource
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