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  • 1980-1984  (11)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Effects of bromocriptine on the secretion of pancreatic juice were investigated with dog isolated, blood-perfused pancreas.2. Bromocriptine (1–10 mg) caused dose-dependent increases in the secretion of pancreatic juice. However, bromocriptine did not affect the perfusion blood flow rate. The secretory response to bromocriptine was inhibited by pretreatment with a dopamine antagonist, sulpiride, but not by phentolamine, propranolol, atropine, metiamide, indomethacin or tetrodotoxin.3. Bromocriptine caused a dopamine-like secretion of the pancreatic juice containing a high concentration of bicarbonate but had little effect on protein output.4. These results suggest that bromocriptine increases pancreatic secretion stimulating directly on pancreatic dopamine receptors.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The difference in the basal activities of NAD+-dependent aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) was investigated in the liver of age-matched spontaneously hypertensive (SH) and normotensive Wistar Kyoto (WK) rats.2. A significant difference between the SH and WK rats in the basal ALDH activity, ADH activity and the protein content of subcellular fractions was observed. The activities of mitochondrial low Km- and high Km-ALDH in the SH rats at 5–8 weeks of age were higher than those in the WK rats. The microsomal high Km-ALDH activity in the SH rats at 5 and 11 weeks of age was higher than that in the WK rats. The ADH activities in the SH rats at 5–14 weeks of age were lower than those in the WK rats. The mitochondrial protein content in the SH rats at 5–14 weeks of age was higher than those in the WK rats.3. At 14 weeks of age, an increase in the blood acetaldehyde level was observed after an intraperitoneal injection of 1.5 g/kg of ethanol in the SH rats. No difference in blood ethanol level was observed between the SH and WK rats.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of optical isomers of nicardipine on the secretion of pancreatic juice and blood flow were investigated in the dog-isolated, blood-perfused pancreas.2. Intra-arterial administration of (-)-nicardipine (10–300 μg) caused a dosedependent increase in pancreatic secretion. However, the (+)-isomer was much less potent than the (-)-isomer and even in 300 μg of (+)-isomer caused only a slight secretion.3. (+)- And (-)-nicardipine increased perfusion blood flow in a dose-dependent manner, and (+)-nicardipine was approximately five times as potent as the (-)-isomers. The maximum increase in a flow rate was produced by 30 μg of (+)-isomer and 100 μg of (-)-isomer.4. Bicarbonate concentration in pancreatic juice induced by (-)- and (+)-nicardipine was increased in a dose-dependent manner, but the protein concentration was only increased slightly.5. From these results, it is concluded that there is a stereoselectivity in the secretory and vascular actions of optical isomers of nicardipine.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of nicardipine on the secretion of pancreatic juice were investigated in dog isolated, blood-perfused pancreas, and compared with those of papaverine, aminophylline and secretin.2. Intra-arterial administration of nicardipine (1-10 μg) elicited a dose-dependent increase in pancreatic secretion. Papaverine (0.1-1 mg), aminophylline (0.3-3 mg) and secretin (0.03-0.1 units) also elicited increased secretion. The secretory activity of nicardipine (10μg) was approximately equal to that of 0.5 mg of papaverine, 1.5 mgof aminophylline and 0.03 units of secretin.3. The concentration of bicarbonate in the pancreatic juice induced by nicardipine was increased, but the protein concentration was only increased slightly. These effects are analogous to those of secretin.4. Nicardipine-induced secretion was not modified by pretreatment with relatively large doses of phentolamine, propranolol, atropine, guanethidine, haloperidol or metiamide.5. Secretin-induced secretion was significantly potentiated by infusion of papaverine, but not by infusion of nicardipine or aminophylline.6.These results suggest that nicardipine acts on the exocrine cells in the dog pancreas, at least in part, through the increase of intracellular cyclic AMP concentration by inhibiting phosphodiesterase activity.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1.Effects of prostacyclin (PGI2) and prostaglandin E2 (PGE2) on the secretion of pancreatic juice were investigated in preparations of the blood-perfused canine pancreas.3 These results suggest that PGE2, but not PGI2, may control the secretory mechanism of the pancreatic secretion in dogs.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of verapamil on dopamine-, secretin- and pancreozymin-induced pancreatic secretion were investigated in the isolated, blood-perfused canine pancreas in vivo.2. The volume of pancreatic secretion either in the resting state or induced by pancreozymin given intra-arterially (i.a.) was decreased by an infusion of 5 μg/min of verapamil; that induced by dopamine or secretin i.a. was also decreased but the changes were not statistically significant.3. Protein concentration in pancreatic juice either in the resting state or in that of stimulated secretion by pancreozymin was decreased significantly, but protein concentration induced by dopamine or secretin was not affected, by verapamil treatment.4. Verapamil had no effect on bicarbonate concentration in pancreatic juice secreted either in the resting state or when stimulated by these secretagogues.5 These results suggest that verapamil, at least in part, may affect the secretory mechanisms of acinar cells but not that of the ductular cells.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 8 (1981), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of 2-nicotinamidoethyl nitrate (SG-75) on the secretion of pancreatic juice were compared with those of acetylcholine, secretin and pancreozymin in the isolated, blood-perfused dog pancreas.2. Intra-arterial administration of SG-75 (0.3-3 mg) elicited a dose-dependent increase in pancreatic secretion. Acetylcholine (10-100 μg), secretin (0.03-0.3 units) and pancreozymin (0.1-1.0 units) also elicited increased secretion.3. Secretory responses to acetylcholine were inhibited by treatment with atropine, while SG-75-, secretin-, and pancreozymin-induced secretions were not modified.4. Bicarbonate concentrations in pancreatic juice induced by SG-75 and secretin were increased in a dose-dependent manner. However, there were slight changes with acetylcholine or pancreozymin.5. Amylase activity in pancreatic juice was increased by SG-75, acetylcholine and pancreozymin, but was decreased by secretin.6. These results suggest that SG-75 stimulates pancreatic secretion by acting both on the acinar and ductular cells of the dog pancreas.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 7 (1980), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of adenosine and adenine nucleotides were studied on arterial vasculature in blood-perfused arterial preparations of dogs which were isolated from the internal and external carotid arteries. Each compound was administered directly into the cannulated artery over a period of 4 s.2. In both arterial preparations, adenosine produced a dose-related vasodilatation and was more potent than AMP. On the other hand, ATP produced a dose-related vasoconstriction and was more potent than ADP.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 7 (1980), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The chronotropic and inotropic effects of the anti-anginal agent SG-75 (2-nicotinamidoethyl nitrate) and 1-verapamil were investigated in isolated blood-perfused canine atrial preparations. The compounds were administered via the cannulated sinus node artery.2. SG-75 induced a selective negative inotropic as opposed to a chronotropic effect. Verapamil showed no selective negative chronotropic or inotropic activity.3. Effects of SG-75 and 1-verapamil on the frequency-force relationship were studied. SG-75 produced a uniform depression of the developed tension at all frequencies tested which the depression with 1-verapamil was greater at higher than at lower frequencies.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three different serotypes of human rotavirus isolates defined in our laboratory were compared by cross neutralization tests with human rotavirus serotypes established in the NIH, U.S.A. The results clearly demonstrated that our three serotypes correspond well to their serotypes Wa, DS-1 and M (or P). Using the three serotype-specific rabbit antisera, all of the 16 strains isolated to date could be assigned to one of those three serotypes. The prevalence of human rotavirus serotypes 1, 2 and 3 among inhabitants of Sapporo and its outskirts was investigated based on the results of neutralizing antibody distribution patterns by age using sera of non-infectious disease patients examined at the Sapporo Medical College Hospital. Neutralizing antibody titers were measured against four strains, KU and K8 (serotype 1), S2 (serotype 2) and YO (serotype 3). The results revealed that serum antibody titers against KU, K8 and YO strains rose with time after birth, reaching the highest antibody distribution levels in either the 3–5-year-old or 6–9-year-old age group, while antibody against S2 strain tended to be lower than that against the other three strains throughout all age ranges examined, with the highest level being shown in the adult group.
    Type of Medium: Electronic Resource
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