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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 22 (1982), S. 494-495 
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 25 (1983), S. 60-65 
    ISSN: 1432-0428
    Keywords: Growth hormone ; prolactin ; insulin binding ; rat hepatocytes ; GH3 pituitary tumours ; post-receptor defect ; glycogen ; receptor defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of chronic elevations of growth hormone levels on hepatic insulin binding and action were studied in rats with subcutaneously implanted growth hormoneproducing tumours. These animals were significantly heavier (p〈0.001; 388±29 versus 239±4 g), had elevated insulin levels, (6.8±0.6 versus 3.3±0.5 ng/ml), lower glucose concentrations (6.0±0.4 versus 9.3±0.5 mmol/l) and larger hepatocyte diameters (28.7±0.6 versus 24.0±0.4 μm) and surface areas (2661±119 versus 1835±65 μm2) than control rats. Insulin binding and action [net (C14)-glucose incorporation into glycogen] were compared in hepatocytes isolated from these two groups. Because of the difference in hepatocyte size, insulin binding was normalized for cell surface area. Binding of the tracer alone (0.9±0.05 versus 1.3±0.12%/cm2) and capacity of the high affinity, low capacity receptor (30.9±5.9 versus 65.2±5.9 sites/μm2) were significantly decreased (p〈0.02) in tumour-bearing rats. Dose-response curves of insulin action in hepatocytes chronically exposed to excess growth hormone were shifted to the right. The maximal response was also significantly decreased. However, the relation between the amount of insulin bound and the proportion of the maximum insulin effect obtained were similar in cells from the two groups. Thus, in rat hepatocytes chronically exposed to excess growth hormone, both a receptor and a post-receptor defect occur while the insulin receptor itself functions normally.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 26 (1984), S. 473-473 
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of management studies 21 (1984), S. 0 
    ISSN: 1467-6486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
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  • 5
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    Unknown
    Canberra : Periodicals Archive Online (PAO)
    Quarterly review of the rural economy. 5:1 (1983:Mar.) 77 
    ISSN: 0156-7446
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Economics
    Description / Table of Contents: COMMODITY SESSIONS
    Abstract: Apples, pears and canning fruit
    Notes: Featuring Outlook '83
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  • 6
    ISSN: 1573-5036
    Keywords: Chelation ; Erwinia-produced 2-ketogluconic acid ; Pasture species contents ; Soil extractions ; Trace elements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Trace element levels extractable by 2-ketogluconic acid (2-KG), ammonium acetate, acetic acid, EDTA, and DTPA were determined in three different soils of the Tarves association. The 2-ketogluconic acid was derived from 2-litre batch cultures of a soil bacterium,Erwinia sp. Pasture grasses and clovers growing on these soils were also analysed. At the same pH, 2-KG extracted more Co, Ni and Zn and considerably more Fe, Ti and V than ammonium acetate. The quantities of Cu, Mn, Mo, Ni and Zn extracted by 2-KG from the three soils generally reflected, in a similar way to the other extractants, the contents of these elements in grasses and clovers growing on the soils.
    Type of Medium: Electronic Resource
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