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Digitale Medien

Enantiomer separation of some aromatic carboxylic acids by HPLC on a chemically bonded β-cyclodextrin stationary phase (1984)

Feitsma, K. G. ; Drenth, B. F. H. ; de Zeeuw, R. A.

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 7 (1984), S. 147-148

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ISSN: 0935-6304

Schlagwort(e): Liquid chromatography ; HPLC ; Racemate separation ; β-Cyclodextrin stationary phase ; Cyclohexylphenylglycolic acid ; Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jhrc.1240070311

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Digitale Medien

High-performance liquid chromatography with continuous gradient elution in screening for unknown metabolites of butoprozine directly in dog bile (1981)

Overzet, F. ; Drenth, B. F. H. ; de Zeeuw, R. A.

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 4 (1981), S. 448-453

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ISSN: 0935-6304

Schlagwort(e): Reverse-phase HPLC ; Continuous gradient elution ; Butoprozine and 14C-labeled butoprozine ; Screening for metabolites in dog bile ; Clean-up of bile ; UV and radiochemical detection ; Differentiation between peaks ; Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: This paper describes the screening for metabolites of butoprozine, a new anti-anginal drug, in dog bile by means of reverse-phase HPLC. Although it does involve a simple clean-up step to remove a substantial amount of endogenous bile compounds, this screening method nevertheless avoids extraction of metabolites and thus allows all metabolites to be introduced into the chromatographic system. A single run of 100 minutes from 100% water to 100% methanol in a linear gradient effects adequate separation of the great majority of metabolites without interference from remaining endogenous compounds.Two methods of differentiating between metabolite peaks and endogenous peaks have been worked out. The first one makes use of 14C-labeled butoprozine by measuring the amount of radioactivity in the column effluent while simultaneously recording the UV absorbance. The second method compares continuous gradient chromatograms of bile recorded before and after butoprozine administration under very similar conditions. The latter method can be applied to both radioactive and non-radioactive materials.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jhrc.1240040905

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Digitale Medien

Screening for unknown compounds by HPLC using a multichannel diode array UV-VIS spectrophotometer: Application to drug metabolism (1982)

Ghijsen, R. T. ; Drenth, B. H. F. ; Overzet, F. ; [weitere]

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 5 (1982), S. 192-198

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ISSN: 0935-6304

Schlagwort(e): Liquid chromatography ; Reverse phase HPLC ; Absorbance ratio ; Spectro-chromatograms ; UV-VIS detector ; Multichannel diode array ; Purity control by HPLC ; Screening for metabolites in dog bile ; Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: This article describes the use of a multichannel UV-VIS detector coupled on-line to an HPLC instrument. Simultaneous measurements of the absorption of a compound over a full range of wavelengths (200-800 nm) makes this almost universal detector a useful tool in screening for unknown compounds. The procedures used to compute so-called spectro-chromatograms and to draw pseudo-three-dimensional plots are discussed. The experimental examples given include an application to screening for drug metabolites in biological fluids.

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jhrc.1240050405

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Digitale Medien

Influence of development distance on resolution in thin-layer chromatography (1983)

Franke, J. P. ; Kruyt, W. ; de Zeeuw, R. A.

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 6 (1983), S. 82-88

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ISSN: 0935-6304

Schlagwort(e): Thin-layer chromatography, TLC ; Resolution ; Optimization ; Development distance ; Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Theoretical equations are given to relate resolution with development distance. Comparative experiments undertaken with quaternary ammonium compounds as test substances and using a selection of basic drugs are presented. As expected, resolution decreases with shorter development distance. However, this effect is less pronounced for compounds with small Rf values and when the spot size at the starting point is kept small. It was also shown that, for correctly assessing resolution in relation to development distance, the amounts of material spotted have to be decreased for shorter development distances.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jhrc.1240060207

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