ISSN:
1432-1912
Keywords:
Quercetin
;
Tyrosine Phosphorylation
;
Protein kinase activity
;
Tumor virus
;
Flavonoids
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The bioflavonoid quercetin is a potent inhibitor of a cyclic nucleotide-independent, tumor virus-coded protein kinase which phosphorylates tyrosine residues and acts as a cellular transforming protein. Half-maximal inhibition of the protein kinase occurred at 3–4 μM quercetin whereas rutin was much less effective. The finding, that quercetin inhibits a cyclic nucleotide-independent protein kinase activity, may provide clues to the diverse pharmacological effects of the bioflavonoids.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00506266
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