Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental pharmacology and physiology
9 (1982), S. 0
ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Liposomes (multilamellar vesicles, MLV) were prepared which entrapped triiodothryonine (T3). The MLV were composed of dimyristoylphosphatidylcholine, cholestrol and dicetylphosphate as DMPC alone, DMPC:Chol (7:2 molar ratio) and DMPC:Chol:DCP (7:2:1 molar ratio).The optimal T3 entrapment was within MLV composed of DMPC: Chol:DCP. The entrapped concentrations of T3 was 63.1%.The MLV composed of DMPC:Chol:DCP did not leak T3 from the MLV into buffered saline but did leak T3 into serum (42.5% after 4 h).The MLV composed of DMPC:Chol:DCP exhibited a distribution of T3 between membrane associated and membrane entrapped of 42:58%.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1982.tb00784.x
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