ISSN:
1432-2072
Keywords:
Δ 9-THC
;
Hypothermia
;
Serotonin
;
Catecholamines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of Δ 9-tetrahydrocannabinol (Δ 9-THC) on body temperature of the mouse was studied. A dose-response relationship (5–100 mg/kg) for the hypothermic effect of Δ 9-THC was seen. The investigation as to the mechanism underlying the hypothermic action of Δ 9-THC was also investigated. The relatively specific dopamine antagonist haloperidol potentiated Δ 9-THC-induced hypothermia as did the α-adrenoceptor antagonist phenoxybenzamine. However, depletion of serotonin with P-chlorophenylalanine reduced the hypothermic response to Δ 9-THC as did pretreatment with the serotonin antagonist methysergide. Inhibition of re-uptake of serotonin with clomipramine potentiated the hypothermia following Δ 9-THC. It is suggested that the hypothermic effect of Δ 9-THC in the mouse is mediated to a large extent via serotonergic mechanisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00433100
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