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  • 1
    Electronic Resource
    Electronic Resource
    Pleomorphism of hepatic regeneration (1984)
    Springer
    Research in experimental medicine 184 (1984), S. 49-57 
    Details
    ISSN: 1433-8580
    Keywords: Hepatic regeneration ; Partial hepatectomy ; Liver damage ; Repair of liver damage ; CCl4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pleomorphism of hepatic regeneration was studied in acute liver injury and partial hepatectomy of rats. Increases in3H-thymidine incorporation into the liver DNA fraction and in liver ornithine decarboxylase (ODC) activity were observed similarly in acute liver injury and following a two-thirds partial hepatectomy in normal rats. However, the increase in serum AFP levels was significant only in carbon tetrachloride (CCl4)-treated rats, and the portal-peripheral vein difference in plasma glucagon concentrations was great only in rats that underwent a partial hepatectomy. The weight of the remaining liver increased rapidly following a 67% hepatectomy in normal rats, but not in cirrhotic rats, of which three of five died within 6 days. Increases in liver prostaglandin E levels,14C-orotate incorporation into the liver RNA fraction and hepatic ODC activity were observed up to 10 h following a partial hepatectomy of normal liver but not after similar removal of cirrhotic liver. Three kinds of hepatic regeneration, i.e., normal and pathologic regeneration following surgical removal of either normal or injured liver and repair of liver damage following chemically induced liver deficiency, were proposed from the observations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852222
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  • 2
    Electronic Resource
    Electronic Resource
    An ultrastructural study of Pick bodies (1984)
    Springer
    Acta neuropathologica 64 (1984), S. 344-348 
    Details
    ISSN: 1432-0533
    Keywords: Pick's disease ; Neuronal inclusion ; Paired helical filament (PHF)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the results of an ultrastructural study of Pick bodies (PB). A histogram constructed with the maximal width of each filamentous component in PB revealed a wide range of sizes among the filaments, in contrast to the unique composition of the paired helical filaments (PHF) seen in the neurofibrillary tangle of Alzheimer type (NFT-AT). Morphologically, three groups of filaments could be distinguished. The first group consisted of straight smooth-surfaced filaments of 10–14 nm diameter, which were presumably altered neurofilaments. The second one was of straight smooth-surfaced “tubules” of 15–22 nm diameter, smaller than normal microtubules. The third one was of PHF thought to be formed by a pair of filaments of the first group. The PHF found in PB differed from PHF of NFT-AT in the distance between corssovers, and rather resembled the loosely interwinding PHF reported in NFT of progressive supranuclear palsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690400
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  • 3
    Electronic Resource
    Electronic Resource
    Distribution of intracytoplasmic acidophilic granule-containing neurons in the human brain (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 145-148 
    Details
    ISSN: 1432-0533
    Keywords: Intracytoplasmic acidophilic granules ; Distribution ; Lewy bodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using four autopsied brains, we studied the anatomic locations of the intracytoplasmic acidophilic granule (IAG)-containing neurons. These neurons occurred in the hypothalamus, zona incerta, insular cortex, and the other 23 nuclei. However, IAGs were not observed in neurons of the Ammon's horn, thalamus, dentale nucleus, or in Purkinje cells of the cerebellum. The distribution of IAG-containing neurons does not exactly correspond to that of the neuromelanin- or monoamine-forming neurons. There is, however, a striking parallelism between the IAG-containing neurons map and the Lewy bodies map. It is suggested by the superimposition of both maps that IAG-containing neurons may have a certain metabolic relation to the formation of Lewy bodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685360
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  • 4
    Electronic Resource
    Electronic Resource
    Light- and electron-microscopic studies of intracytoplasmic acidophilic granules in the human locus ceruleus and substantia nigra (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 78-80 
    Details
    ISSN: 1432-0533
    Keywords: Intracytoplasmic acidophilic granules ; Melanin-bearing neurons ; Round electron-dense body ; Mitochondrial inclusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the brains of 30 patients with mental and neurologic disorders, we studied the intracytoplasmic acidophilic granules in neurons of the substantia nigra and locus ceruleus by light and electron microscopy. The granules were present in all 30 brains, including those with no recognizable pathologic change, there was no correlation between their appearance and the age, sex, disease of, or the medication received by, the patients. In four electron-microscopically examined brains, we noted many small, round electron-dense bodies in the perikarya and neuronal processes of the substantia nigra and locus ceruleus. The bodies were packed tightly within a double membrane; in shape, size, and distribution in the neuronal cytoplasm, they corresponded to acidophilic granules. Some mitochondrial matrices contained one or more similar, but smaller inclusion bodies; larger bodies pushed aside the mitochondrial cristae. We conclude that the acidophilic granules represent highly developed forms of mitochondrial inclusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691186
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  • 5
    Electronic Resource
    Electronic Resource
    A new method for detection of anti-zona activity in human sera using latex agglutination reaction (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 926-928 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A slide latex test for detection of anti-zona pellucida activity in human sera was developed using a latex agglutination reaction. The latex reagent, made of polystyrene particles coated with solubilizing zona antigen(s), was found to give results comparable in sensitivity as well as specificity to those of the indirect immunofluorescence method as tested with anti-pig-zona antiserum and with human sera. Thus, the slide latex test was judged to be adequate for use instead of the indirect immunofluorescence technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990442
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  • 6
    Electronic Resource
    Electronic Resource
    Hybridization of tRNAs of Drosophila melanogaster to polytene chromosomes (1980)
    Springer
    Chromosoma 76 (1980), S. 65-84 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Highly purified tRNAs from Drosophila melanogaster were iodinated with 125I and hybridized to squashes of polytene chromosomes of Drosophila salivary glands followed by autoradiography to localize binding sites. Most tRNAs hybridize strongly to more than one site and weakly to one or more additional sites. The major sites for various tRNAs are the following: tRNA 2 Arg , 42A, 84F1,2; tRNA 2 Asp , 29DE; tRNA 3 Gly , 22BC, 35BC, 57BC; tRNA 2 Lys , 42A, 42E; tRNA 5 Lys , 84AB, 87B; tRNA 2 Met , 48B5–7, 72F1–2, 83F-84A; tRNA 3 Met , 46A1–2, 61D1–2, 70F1–2; tRNA 4 Ser , 12DE, 23E; tRNA 7 Ser , 12DE, 23E; tRNA 3a Val , 64D; tRNA 3b Val , 84D3–4, 92B1–9; tRNA 4 Val , 56D3–7, 70BC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292227
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  • 7
    Electronic Resource
    Electronic Resource
    Hybridization of tRNAs of Drosophila melanogaster to the region of the 5S RNA genes of the polytene chromosomes (1981)
    Springer
    Chromosoma 82 (1981), S. 385-397 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have previously reported that four tRNAs of Drosophila melanogaster randomly labeled with iodine-125 hybridize in part to the 56EF region of polytene chromosomes where 5S RNA genes occur. In the presence of a 100-fold excess of unlabeled 5S RNA no hybridization of randomly labeled 125I-tRNAAsp 2γ occurred at 56EF although hybridization elsewhere was not affected. In addition, tRNAAsp 2γ labeled by introducing 125I-5-iodocytidylyl residues into the 3′-CCA end with tRNA nucleotidyl transferase did not hybridize to 56EF but did hybridize to its other sites. The hybridization of tRNALys 2, tRNAGly 3 and tRNAMet 3 at 56EF was not eliminated by a 25 to 100-fold excess of unlabeled 5S RNA. When these tRNAs were labeled at the -CCA terminus they hybridized to 56EF as well as to their other sites with the exception that terminally labeled tRNALys 2 no longer hybridized to 62A. The hybridization of the latter three species of tRNA to the region of the 5S genes, amongst other sites, is confirmed. The previously observed hybridization of tRNAAsp 2γ in this region appears to have been due to contamination of the tRNA sample with traces of material derived from 5S RNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285764
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  • 8
    Electronic Resource
    Electronic Resource
    Localization of tRNA genes of Drosophila melanogaster by in situ hybridization (1982)
    Springer
    Chromosoma 86 (1982), S. 279-292 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Six purified tRNAs labeled with 125I by chemical or enzymatic methods were hybridized to polytene chromosomes of Drosophila melanogaster. The main chromosomal regions of hybridization were: tRNA GGA Gly , 58A, 84C, and 90E; tRNA 2 Leu , 44E, 66B5-8, and 79F; tRNA 2b Ser , 86A, 88A9-12, and 94A6-8; tRNA 3 Thr , 47F and 87B; tRNA 4 Thr , 93A1-2; and tRNA 1γ Tyr , 19F, 22F-23A, 41, 50C1-4 and 85A. At 50C the hybridization of tRNA 1γ Tyr was polymorphic in the giant strains. When the hybridization of three valine isoacceptors studied previously was re-investigated, it was found that only one hybridization site, 90BC, was shared between tRNA 3b Val and tRNA 4 Val . tRNA 3a Val did not have any sites in common with the other two.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00288682
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  • 9
    Electronic Resource
    Electronic Resource
    Enrichment of Propionibacterium in paddy soil by addition of various organic substances (1980)
    Springer
    Antonie van Leeuwenhoek 46 (1980), S. 313-320 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Enrichment of Propionibacterium and production of propionic acid in paddy soil after addition of glucose, casamino acids, or Na-lactate, respectively, were investigated. Only in the case of Na-lactate, both enrichment of Propionibacterium (74% of total anaerobes isolated) and production of large amounts of propionic acid were observed. These results suggest that lactate may support the growth of Propionibacterium in paddy soil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421978
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