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  • 1
    Electronic Resource
    Electronic Resource
    EXPERIMENTAL CHEMICAL PRODUCTION OF BRAIN TUMORS (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 381 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb50390.x
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  • 2
    Electronic Resource
    Electronic Resource
    Diet and cancer (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 1-10 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions Since unbalanced diets may increase the carcinogenic risk for certain organs, a balanced form of nutrition is to be recommended from the present point of view. It can also be recommended to avoid hyperalimentation, since this seems to have a positive effect on the cancer mortality risk; furthermore, ideal-weight individuals run a definitely lower risk of suffering a cardiac infarct than overweight individuals. Certain anticancer diets cannot be established. But the intake of juices and salads with a high vitamin C content can inhibit the formation of nitrosamines directly after the intake of food, because the nitrosation is prevented by nitrite interception. Negative influences of diets with a high fiber content are not known. Positive effects are discussed. Since it also prevents obstipation, it can well be recommended. Since dietary habits cannot shortly and easily be changed and changes in nutrition have a considerable impact on the personal quality of living, recommendations favoring certain diets should be given with all due caution. In our opinion the scientific basis for recommendations seems to be too small to justify very restrictive diets for cancer prevention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412892
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  • 3
    Electronic Resource
    Electronic Resource
    Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats (1981)
    Springer
    Journal of cancer research and clinical oncology 102 (1981), S. 153-157 
    Details
    ISSN: 1432-1335
    Keywords: Benzo(a)pyrene ; Caffeine ; Oral administration ; Tumors of the forestomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a lifetime experiment benzo(a)pyrene (B(a)P) was administered to Sprague-Dawley rats either as an admixture to the diet or by gavage in an aqueous 1.5% caffeine solution. Dissolved benzo(a)pyrene induced more tumors of the forestomach than undissolved benzo(a)pyrene. The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410666
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  • 4
    Electronic Resource
    Electronic Resource
    Induction of tumors of the forestomach in rats by oral application of N-methyl-N′-nitro-nitrosoguanidine (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 194-196 
    Details
    ISSN: 1432-1335
    Keywords: N-Methyl-N′-nitro-N-nitrosoguanidine ; tumors in forestomach ; glandular stomach ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After 12 oral applications of 80 mg/kg MNNG as a suspension in 30% aqueous ethanol at weekly intervals, 98 Sprague-Dawley rats died with multiple tumors of the forestomach after a medium latency period of 226 days. Histological examination showed generalized papillomatosis developing into keratinizing squamous cell carcinomas with infiltrative growth in 88/98 (89%) animals. Tumorigenic lesions in the glandular stomach ware only observed in 3/98 rats. In two of these animals, mucosal adenocarcinomas were found and in the third a leiomyosarcoma. In about 30% of the animals treated with MNNG, degenerative liver changes were found, especially single cell and focal necroses, cystic alterations, and bile-duct proliferations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406933
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  • 5
    Electronic Resource
    Electronic Resource
    Carcinogenic activity of condensate from coloquint seeds (Citrullus colocynthis) after chronic epicutaneous administration to mice (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 154-156 
    Details
    ISSN: 1432-1335
    Keywords: Citrullus colocynthis seed condensate ; Tars in African folk medicine ; Carcinogenicity in mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the Sahelian countries coloquint seed tar is used in traditional medicine. A condensate from the seed of Citrullus colocynthis was obtained in a camel nomad settlement. It contained a large number of polycyclic aromatic hydrocarbons, including known carcinogens [e.g., benzo(a)pyrene, benz(a)anthracene, benzo(b)fluoranthene, benzo(j)fluoranthene]. The dose-related carcinogenic activity of this condensate was established after chronic epicutaneous application to mouse skin. We conclude that the manufacture and use of coloquint tar and related compounds may involve a health hazard and could lead to the development of cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390988
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  • 6
    Electronic Resource
    Electronic Resource
    Antitumor activity of new nitrosoureas on Yoshida sarcoma ascites cells implanted into the colon wall of rats (1981)
    Springer
    Journal of cancer research and clinical oncology 101 (1981), S. 285-302 
    Details
    ISSN: 1432-1335
    Keywords: Yoshida sarcoma ; Descending colon ; 2-Chloroethyl-nitrosoureas ; Sprague-Dawley rats ; Yoshida-Sarkom ; Colon descendens ; 2-Chlorethyl-nitrosoharnstoffe ; Sprague-Dawley-Ratten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die chemotherapeutische Wirkung von 12 neu entwickelten Nitrosoharnstoffen wurde vergleichend an Yoshida-Sarkom-Asziteszellen experimentell untersucht, die in die Wand des Colon descendens von Sprague-Dawley-Ratten implantiert worden waren. Cyclophosphamid sowie die Nitrosoharnstoffe BCNU, MeCCNU und Chlorozotocin dienten als positive Kontrolle. Unter den untersuchten Nitrosoharnstoffen zeigten 1-(2-Hydroxyethyl)-3-(2-chlorethyl)-3-nitrosoharnstoff (Hydroxyethyl-CNU), Chlorozotocin, 1-(2-Chlorethyl)-1-nitroso-3-(4-morpholino)-harnstoff, 1-(2-Chlorethyl)-1-nitroso-3-(1-piperidino)-harnstoff, 4-[1-(2-Chlorethyl)-1-nitroso]-3-[4-(2,6-dimethylmorpholino)]-harnstoff und 1-(2-Chlorethyl)-1-nitroso-3-(3,4-methylendioxybenzyl)-harnstoff die stärkste Aktivität in diesem Tumormodell. Auf Grund der vorliegenden Ergebnisse ist Morpholino-CNU als die erfolgversprechendste Substanz unter den neu synthetisierten BCNU-Analogen anzusehen.
    Notes: Summary The chemotherapeutic activity of 12 newly synthesized nitrosoureas was compared in tests using Yoshida sarcoma ascites cells implanted into the wall of the descending colon in Sprague-Dawley rats. Cyclophosphamide and the nitrosoureas, BCNU, MeCCNU, and chlorozotocin served as positive controls. Among the nitrosoureas tested, 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (hydroxyethyl-CNU), chlorozotocin, 1-(2-chloroethyl)-1-nitroso-3-(4-morpholino) urea, 1-(2-chloroethyl)-1-nitroso-3-(1-piperidino) urea, 4-[1-(2-chloroethyl)-1-nitroso]-3-[4-(2,6-dimethylmorpholino)] urea, and 1-(2-chloroethyl)-1-nitroso-3-(3,4-methylenedioxybenzyl) urea were found to be the most active compounds in this tumor model. Based on the present results, morpholino-CNU is considered the most promising compound among these newly synthesized BCNU analogues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410114
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of daily subcutaneous administration of 6-methylprednisolone and oral application of 30% saline solution on tumorigenesis induced in mouse stomach by single application of 7,12-dimethylbenz(a)anthracene (1982)
    Springer
    Journal of cancer research and clinical oncology 103 (1982), S. 207-209 
    Details
    ISSN: 1432-1335
    Keywords: DMBA ; Prednisolone ; 30% Saline Solution ; Ulcers and papilomas of the forestomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Combined treatment with DMBA, 6-methylprednisolone, and 30% saline solution induced papillomas in the forestomach of mice after a median latent period of 25 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409650
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  • 8
    Electronic Resource
    Electronic Resource
    Carcinogenicity of di(N-nitroso)perhydropyrimidine (DNPP) after repeated low-dose intraperitoneal administration to rats (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 191-193 
    Details
    ISSN: 1432-1335
    Keywords: Di(N-nitroso)perhydropyrimidine ; Carcinogenicity in rats ; Squamous-cell carcinomas of the paranasal sinus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We administered 0.07 (group I), 0.2 (group II), and 0.7 (group III) mg/kg body wt. di(N-nitroso)perhydropyrimidine (DNPP) intraperitoneally to male Sprague-Dawley rats once a week for life. DNPP treatment resulted in reduced survival times according to a dose-related pattern. Median survival times from the beginning of the experiment were 888 days in controls, 482 days in group I, 463 days in group II, and 122 days in group III. DNPP induced squamous-cell carcinomas of the paranasal sinus. No treatment-related tumors were seen in the 40 rats treated with the lowest dose of DNPP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406932
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  • 9
    Electronic Resource
    Electronic Resource
    Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 250-257 
    Details
    ISSN: 1432-1335
    Keywords: Yoshida sarcoma ; Glandular stomach ; 5-Fluorouracil, methyl-CCNU, mitomycin C, adriamycin, cytosine arabinoside ; Two-drug combinations ; Sprague-Dawley rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The chemotherapeutic activity of five cytostatic drugs was investigated experimentally in monotherapy and in two-drug combinations, using Yoshida sarcoma cells implanted into the wall of the glandular stomach of Sprague-Dawley rats. In monotherapy, the antibiotic agent mitomycin C and the nitrosourea methyl-CCNU exhibited the highest cytotoxic activity in this tumor model. In combination therapy, the combination of these two drugs was superior to all the other therapeutic schemes tested. In general, the results demonstrate a marked superiority of combination therapy in comparison with monotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395753
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  • 10
    Electronic Resource
    Electronic Resource
    Comparative metabolism and carcinogenicity of ring-halogenated 3,3-dimethyl-1-phenyltriazenes (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 71-75 
    Details
    ISSN: 1432-1335
    Keywords: Metabolism ; Carcinogenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The objective of this study was to compare urinary metabolism of parent 3,3-dimethyl-1-phenyltriazene with that of its ring-substituted 1-(4-chlorophenyl)-3,3-dimethyltriazene and 1-(2,4,6-trichlorophenyl)-3,3-dimethyltriazene congeners, in an attempt to evaluate the molecular requirements for systemic carcinogenic activity. Complementary carcinogenicity assays were conducted at low equimolar dose levels using both 4- und 2,4,6-chlorinated and brominated analogues. Ring halogenation was found to prolong metabolic detoxification and to reduce carcinogenic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390976
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