ISSN:
1432-1912
Keywords:
Ergot alkaloids
;
Antiparkinson agents
;
Neuroleptics
;
Antidepressants
;
CNS-receptors
;
Affinities to multiple binding sites
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The affinity for eight different neurotransmitter receptors of about fourty drugs, used for the treatment of various central nervous system disorders, was determined following in vitro receptor binding assays. Our findings indicate that, in spite of widely varying chemical structures and often poorly understood mechanisms of action, the similarities in the “affinity profiles” permit a clinically meaningful classification of these drugs. Such an approach would thus be useful in the assessment of newly synthesized compounds at an early stage of drug development.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00500901
Permalink