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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 417 (1983), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Isolated ventricular cells12 stimulated at 0.33 Hz through the injection electrode had a resting potential of approximately -80 mV and stable action potentials of 150-300 ms duration. Injection of C prolonged the APD measured at 80% repolariz-ation (APD80) from 130 to 315 ms and increased AP ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Computing 31 (1983), S. 141-148 
    ISSN: 1436-5057
    Keywords: 68C01 ; Petri net classes ; synchronization problem ; simulation rules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung In diesem Beitrag greifen wir ein Problem aus [1] auf, nämlich die Frage, ob PNlog-Netze Synchronisationsprobleme zu lösen gestatten, die, unter Einhaltung bestimmter Simulationsregeln, mit gewöhnlichen Petri-Netzen nicht lösbar sind. Wir zeigen, daß eine geringfügige und sinnvolle Verschärfung der in [1] präzisierten Simulationsregeln ausreicht, um die aufgeworfene Frage im positiven Sinne beantworten zu können. Wie in der Einleitung näher begründet wird, lösen wir damit auch teilweise das ursprüngliche Problem.
    Notes: Abstract In this article we pick up a problem stated in [1], namely the question whether PNlog-nets allow to solve synchronization problems not solvable by ordinary Petri nets under certain simulation rules. We show that a slight and reasonable strengthening of the simulation rules defined in [1] enables us to answer the raised question in the positive. As will be pointed out in the introduction, with this result we “partially” solve the original problem.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1912
    Keywords: Myosin light chain kinase ; Vasodilator drugs ; Fendiline ; Nifedipine ; Verapamil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Renal arteries from rabbits were chemically skinned by incubation with Triton X-100, and subsequently stored in buffered glycerol. 2. In the presence of Mg-ATP, of EGTA-buffered calcium, and of calmodulin, miniature strips of the skinned arteries developed tension the strength of which was approx. 15–20% of that of viable renal arteries. 3. Tension development was dependent on the concentration of both calcium and calmodulin. 4. The effect of eight vasodilator drugs, the majority of them being “calmodulin antagonists” or “calcium antagonists”, on the skinned arteries was assessed. In concentrations up to 10−3 M, verapamil, D-600, and hydralazine proved to be ineffective, and the same was found with the dihydropyridine derivatives, nifedipine and felodipine, at 0.6×10−3 M and 0.8×10−4 M, respectively, i.e. at saturation in a 9∶1 contracting buffer/ethanol mixture (v/v). 5. In a concentration-dependent manner, trifluoperazine, W-7, and fendiline relaxed Ca-calmodulin-induced tension or prevented tension development when given prior to the activation by Ca-calmodulin. However, considerably higher concentrations of the drugs were necessary for half-maximal relaxation than the reported concentrations for half-maximal saturation of hydrophobic binding sites at the calmodulin molecule. 6. These findings suggest that at therapeutic blood levels, the vasodilator properties of calcium antagonists and other direct vasodilators cannot be explained by interference with the binding of myosin light chain kinase to calmodulin.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 401 (1984), S. 277-280 
    ISSN: 1432-2013
    Keywords: cGMP ; cAMP ; Skinned coronary arteries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of physiological concentrations of cGMP and cAMP on tension development in skinned coronary arteries (Triton X-100) were studied. cGMP inhibited tension elicited at intermediate Ca2+ concentrations at pH 7.0 but not at more acidic or alkaline pH values. cAMP, on the other hand, decreased submaximal tension development independent of pH (from pH 6.5 to pH 7.2). Neither nucleotide affected tension development at maximally activating Ca2+ concentrations.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2013
    Keywords: Adrenaline ; cAMP-dependent protein kinase ; Slow inward calcium current ; Inotropy ; K outward current ; Transient inward current
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cyclic adenosine 3′,5′-monophosphate (cAMP) or the free catalytic subunit (C) of the cAMP-dependent protein kinase were pressure injected into single guinea pig ventricular cells. The following results were obtained: 1. Injection of cAMP prolonged the action potential and shifted the action potential plateau to a more positive level. Under voltage clamp, cAMP injection increased the amplitude of the slow inward calcium current (I si). 2. Injection of C permanently prolonged the action potential and enhanced the amplitude ofI si by a factor of 2–4, depending on the amount of injected C. In the current-voltage relations the potential of maximumI si and the apparent current reversal did not change. 3. After maximum prolongation of the action potential due to repeated injections of C, even high concentrations of adrenaline did not further change the configuration of the action potential. 4. In many experiments transient depolarizations appeared after the injection. Correspondingly, under voltage clamp transient inward currents occurred. 5. C injection increased both the time-dependent and time-independent potassium outward current. 6. In response to injection of the catalytic subunit, the isotonic contraction was larger in amplitude and relaxation was faster. It is concluded that the cAMP-dependent protein kinase increases the slow inward calcium current in the heart, presumably by phosphorylation of some membrane proteins.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 481 (1981), S. 168-174 
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Investigation on Acidity and Catalytic Activity of Deep-Bed Calcinated Zeolites NH4 NaYNMR and infrared techniques are applied to decationated zeolites NaY to study Brönsted acidity. The results are compared with measurements of catalytic activity and crystallinity of this zeolites.The number of OH groups which are able to form a pyridinium ion (PyH+) increases with increasing exchange degree and with increasing temperature of the sample. The rate of pyridinium ion formation as an equivalent of Brönsted acidity and the catalytic activity increase similarly with increasing exchange degree up to such values where a loss of crystallinity occurs.
    Notes: Methoden der NMR- und der IR-Spektroskopie werden zur Charakterisierung der Brönsted-Acidität unterschiedlich dekationisierter NaY-Zeolithe eingesetzt. Die erhaltenen Ergebnisse werden im Zusammenhang mit den Ergebnissen katalytischer Messungen und Kristallinitätsuntersuchungen interpretiert.Es zeigt sich, daß die Zahl der an der Bildung von Pyridiniumkationen (PyH+) beteiligten OH-Gruppen sowohl mit wachsendem NH4+-Austauschgrad als auch bei Erhöhung der Meßtemperatur zunimmt. Die Geschwindigkeit der Bildung von Pyridiniumkationen als relatives Maß für die Brönsted-Acidität und die katalytische Spaltaktivität verändern sich in der gleichen Weise mit dem Austauschgrad. In Proben mit höheren Austauschgraden werden Acidität und Aktivität von Kristallinitätsverlusten beeinflußt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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