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  • 1
    Electronic Resource
    Electronic Resource
    Role of the Ek Molecule in the Generation of Suppressor T Cells in Response to LDHB (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 16 (1982), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The role of the Ek (EαEβk) molecule in the generation of suppressor T (Ts) cells specific for lactate dehydrogenase B (LDHB) was studied using different approaches. First, lymph node cells from LDHB-primed B1O.A(2R) (AkEk) nonresponder mice were shown to suppress the LDHB-specific and Ak-restricted proliferative response of T cells from the congenic responder strain B10.A(4R), which does not express E molecules (AkEo). Similarly, lymph node cells from primed CBA (AkEk) mice suppressed the anti-LDHB response of Lyt-1+Lyt-2- T celfs (depleted of Lyt-2-bearing TS cells) from the same mice. Second, in vitro priming of 2R (AkEk) T cells with LDHB-pulsed 4R (AkEo) antigen-presenting cells (APC) generated T-cell proliferation but not suppression. Third, nonresponder 2R mice were turned into responders by injecting them with LDHB-pulsed 4R APC or monoclonal Ia.m7 antibody that blocks the Ek molecule. The data demonstrate that expression of Ek molecules by the APC is necessary to generate LDHB-specific Ts cells, which in turn prevent the proliferation of Lyt-l+Lyt-2- (probably helper) cells recognizing the same antigen in the context of the Ak molecule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1982.tb00695.x
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  • 2
    Electronic Resource
    Electronic Resource
    Polarity of myofilaments in molluscan smooth muscle (1983)
    Springer
    Cell & tissue research 234 (1983), S. 533-545 
    Details
    ISSN: 1432-0878
    Keywords: Molluscan smooth muscle ; Thick filament ; Thin filament ; Central bare zone ; Polarity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Myofilaments were isolated by gently homogenizing smooth muscle cells isolated from the pedal retractor muscle (PRM) of Mytilus edulis, and observed by electron microscopy. The thick filaments isolated in the presence of ATP (10–20 mM) had projections of myosin heads except near their centre (central bare zone). After extraction of myosin, the paramyosin core of the thick filaments showed a Bear-Selby net or a striated pattern with a main periodicity of 14.5 nm. Both the Bear-Selby net and the striated patterns had a polarity that reversed at the centre of the filament where the patterns were obscured. The thin filaments were attached to dense bodies. Decoration of the thin filaments with heavy meromyosin showed that they have opposite polarity on opposing sides of the dense body. The results indicate that the thick filaments are bipolar and also that the dense bodies are functionally analogous to the Z-disk of the striated muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218649
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Algorithm for detecting the first and the second heart sounds by spectral tracking (1980)
    Springer
    Medical & biological engineering & computing 18 (1980), S. 19-26 
    Details
    ISSN: 1741-0444
    Keywords: First heart sounds ; Linear prediction ; Phonocardiogram ; Second heart sounds ; Spectral tracking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A detection algorithm for the first and the second heart sounds, which is one of the most important problems in an automatic diagnostic system for phonocardiograms, has been developed. It is based on the frequency-domain characteristics of heart sounds analysed by a linear-prediction method. The performance of the algorithm has been evaluated in 187 samples that contain 881 cardiac cycles including normal and abnormal subjects. The algorithm uses low frequency spectral tracking for the time series of the phonocardiogram. It can track spectral level smoothly so that it is fairly effective for the detection of heart sounds. This tracking procedure can be used in other applications such as electroencephalogram processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442475
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    Paper (German National Licenses)
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