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  • 1
    Electronic Resource
    Electronic Resource
    Failure of a Fluotec Mk II (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 37 (1982), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The sump of a Fluotec Mk II vaporiser separated from the upper portion of the vaporiser during an anaesthetic, and fell off. The danger to the patient is discussed, as well as the possible causes for this occurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1982.tb01857.x
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  • 2
    Electronic Resource
    Electronic Resource
    Phase I trial of 4′-deoxydoxorubicin given weekly (1984)
    Springer
    Investigational new drugs 2 (1984), S. 369-374 
    Details
    ISSN: 1573-0646
    Keywords: Phase I trial ; 4′-deoxydoxorubicin ; esorubicin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-six patients with various solid tumors entered a Phase I trial with 4′ -Deoxydoxorubicin (Esorubicin, IMI-58), a new doxorubicin analogue. The drug was administered weekly i.v. for 3–4 weeks. Leukopenia proved to be dose limiting. The maximum tolerated dose (MTD) was reached at 20 mg/m2 weekly for 3 weeks. For Phase II trials, a weekly dose of 15 and 17.5 mg/m2 can be proposed for poor and good risk patients respectively. Non-hematologic toxicity was minimal. Phase II trials with this new anthracycline are warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171587
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Phase I trial of 4-demethoxydaunorubicin (idarubicin) with single oral doses (1984)
    Springer
    Investigational new drugs 2 (1984), S. 281-286 
    Details
    ISSN: 1573-0646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-four patients with a variety of solid tumors entered a Phase I trial with 4-demethoxydaunorubicin, a new analogue of daunorubicin. The drug was given as a single oral dose of 10–60 mg/m2 repeated every 3–4 weeks. Leukopenia was the dose-limiting toxicity. Other toxic effects included mild to moderate nausea and vomiting. Sixty mg/m2 was found to be the maximum tolerated dose in patients with fair tolerance to chemotherapy and normal liver function. Similar hematologic toxicity was reported in patients with very extensive prior chemotherapy or diffuse bone and/or liver metastases receiving 50 mg/m2. However, the wide range of the WBC nadirs reported with the same dose in ‘good risk’ cases, suggest that 40 mg/m2, increased up to 50 mg/m2 in the absence of significant myelotoxicity, could be more safely proposed as starting dose for Phase II trials. Pharmacokinetic studies were performed in five patients given a single dose of 40–60 mg/m2. IMI-30 (NSC 256439) appears to be rapidly absorbed and rapidly eliminated from plasma by means of a rapid and extensive biotransformation to 13-OH-idarubicin. The 13-dihydroderivative was present at higher and more prolonged levels than the parent compound, with an elimination half-life of about 40 hours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175378
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The structure of plasma-polymerized toluene: A solid-state 13C-NMR study of isotopically labeled polymers (1983)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 21 (1983), S. 1819-1829 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A detailed magic angle spinning 13C-NMR investigation of the intractable polymer prepared by plasma polymerization of toluene and isotopically labeled toluene led to a proposed model for the structure of the polymer and suggested some of the likely processes that occur in the gas phase leading to film formation. From the 13C spectra four resolved resonances permitted the determination of the contribution of nonprotonated and protonated unsaturated as well as methyl and other aliphatic carbons to the polymer structure. Specific 13C isotopic labeling of the methyl and phenyl C-1 toluene carbons in the injected liquid vapor allowed the destination of these carbons in the deposited polymer to be traced. The dominant structure is derived primarily from two precursors: benzyl radical and toluene itself. The 13C data further requires a net saturation of ca. 30% of the toluene double bonds and a net displacement of hydrogen by carbon on ca. 20% of the toluene ring carbons.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1983.170210622
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  • 5
    Electronic Resource
    Electronic Resource
    A 13C-NMR investigation of plasma polymerized ethane, ethylene, and acetylene (1981)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 19 (1981), S. 2987-2996 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Solid-state 13C-NMR spectra were obtained by cross-polarization and magic angle spinning of polymers prepared by injecting ethane, ethylene, and acetylene into a radiofrequency plasma. By use of the delayed decoupling technique to suppress protonated carbon peaks and difference spectroscopy five resolved spectral bands can be distinguished. These bands are assigned to (I) unsaturated nonprotonated, (II) unsaturated CH and CH2, (III) quaternary, (IV) methine and methylene, and (V) methyl carbons by comparison with standard 13C shifts compiled for organic materials. The relative amounts of these structural features in the polymers were determined quantitatively and the possible sources of errors considered.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1981.170191130
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    Paper (German National Licenses)
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