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Digitale Medien

Regional Distribution of Kininase in Rat Brain (1981)

Kariya, K. ; Kawauchi, R. ; Okamoto, H.

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 36 (1981), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: Kininase activity, which inactivates kinins, was measured in seven regions of the rat brain (i.e., the cerebral cortex, cerebellum, striatum, midbrain, hippocampus, hypothalamus, medulla oblongata), and in the spinal cord with a bioassay method using bradykinin as the substrate. Specific kininase activities in the cerebellum and striatum were higher than those in the other five regions or the spinal cord. Angiotensin-converting enzyme activity, which was measured fluorometrically using Hip-His-Leu as substrate, showed high activity in the striatum and cerebellum. These findings suggest that the presence of high concentrations of peptidases plays a role in the degradation of kinins and/or other peptides in these areas.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb10838.x

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Digitale Medien

The effect of propylthiouracil on glutathione S-transferase activity of rat spleen in vitro and in vivo (1983)

Kariya, K. ; Lee, E. ; Matsue, T.

Springer

Cellular and molecular life sciences 39 (1983), S. 896-898

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ISSN: 1420-9071

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary Propylthiouracil (PTU) inhibited glutathione (GSH) S-transferase (EC 2.5.1.18) activity of rat spleens in a concentration dependent manner in vitro. PTU (1.5 mmoles/kg) treatment of rats for 1 or 2 weeks caused a decrease in leukocyte number and spleen weight. Nevertheless, GSH S-transferase activity was not affected by the same treatment.