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Hypothalamic-pituitary dopaminergic function in hepatic failure in man (1982)

Lal, S. ; Oravec, M. ; Aronoff, A. ; [et al.]

Springer

Journal of neural transmission 53 (1982), S. 7-21

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ISSN: 1435-1463

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The growth hormone (GH) response to apomorphine HCl (Apo) (0.75 mg sc), a dopamine (DA) receptor agonist, was assessed in healthy chronic alcoholics without cirrhosis (N=20) and in patients with alcoholic cirrhosis both with (N=5) and without (N=14) hepatic encephalopathy (HE). A significant number of cirrhotic patients with (P〈0.004) and without (P〈0.002) HE had an impaired GH response (peak increment〈5 ng/ml) compared with non-cirrhotic individuals. An impaired GH response was independent of the presence of HE. The magnitude of the GH response was unrelated to plasma oestrone, oestradiol, or progesterone concentrations but was significantly correlated with plasma testosterone levels (P〈0.01). None of the patients with an abnormally low testosterone concentration showed a normal GH response. None of the subjects with HE showed an arousal response to Apo. These results suggest that DA receptor sensitivity is decreased in liver cirrhosis and that this decrease is related to inadequate circulating levels of testosterone. The occurrence of HE is independent of impaired DA function. The present study only evaluates DA function in the hypothalamic-pituitary axis and therefore may not reflect changes in other regions of brain.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01243516

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Intercellular bridges in ovaries of the newborn gerbil (1984)

McReynolds, H. D. ; Blanchet, L. J. ; Bowman, D. C. ; [et al.]

New York, NY : Wiley-Blackwell

Journal of Morphology 180 (1984), S. 29-35

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ISSN: 0362-2525

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: This study describes intercellular bridges in the ovaries of neonatal gerbils. Electron microscopy has revealed the presence of true intercellular bridges, connecting oogonia or oocytes, in ovaries of newborn gerbils. The cytoplasm of the intercellular channels is similar to that of the connected cells, with mitochondria, smooth and rough endoplasmic reticulum, and free ribosomes present. Lysosomes are also occasionally present in the intercellular bridges and they may be involved in early waves of oocyte atresia. An electrondense substance, 350-500 Å thick, is located immediately beneath the unit membrane of the intercellular bridges. Accumulation of electron-dense material increases the thickness of the walls of the intercellular bridges, supporting and maintaining the patency of the channels. It is suggested that the intercellular channels probably allow the interchange of nutrients, organelles, and possibly regulatory materials as well.

Additional Material: 6 Ill.