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  • 1
    Electronic Resource
    Electronic Resource
    Poly(tertiary phosphines and arsines). 20. Some reactions of (methylamino)bis(dimethoxyphosphine) and crystal structure of (.mu.-carbonyl)[.mu.-(methylamino)bis(dimethoxyphosphine)]bis(tricarbonyliron), CH3N[P(OCH3)2]2Fe2(CO)7 (1982)
    s.l. : American Chemical Society
    Inorganic chemistry 21 (1982), S. 3790-3794 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00140a037
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  • 2
    Electronic Resource
    Electronic Resource
    Metal complexes of fluorophosphines. 11. Further observations on iron carbonyl complexes of (methylamino)bis(difluorophosphine) (1983)
    s.l. : American Chemical Society
    Inorganic chemistry 22 (1983), S. 2964-2967 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00162a043
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  • 3
    Electronic Resource
    Electronic Resource
    Oxidation-state-specific detection of uranium in aqueous solution by photoacoustic spectroscopy (1983)
    Springer
    Applied physics 32 (1983), S. 207-209 
    Details
    ISSN: 1432-0649
    Keywords: 78.20.Hp ; 33.90.+h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract By means of photoacoustic spectroscopy it has been possible to detect U(IV) and U(VI) in aqueous solution in the 10−6 M/L range. Piezoelectric transducer detection, pulsed laser radiation and a differential method to reduce solvent and window absorption has been used. Photoacoustic spectroscopy seems to be a suitable method for the low level detection of actinide elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688289
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of Motor and Premotor Cortex Ablation on Concentrations of Amino Acids, Monoamines, and Acetylcholine and on the Ultrastructure in Rat Striatum. A Confirmation of Glutamate as the Specific Cortico-Striatal Transmitter (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 38 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: At 1, 2, and 4 weeks after unilateral premotor and motor cortex ablation in rats, a significant and lasting decrease in glutamate levels in the ipsilateral versus contralateral striatum was observed. A significant corresponding fall in aspartate was seen only after 1 week. In contrast, there was a large increase in the striatal concentrations of lysine, threonine, alanine, and glutamine 1 week after the cortical ablation. This correlates with the extensive glial proliferation in the deafferented ipsilateral striatum. Four weeks after cortical ablation the GABA concentration was significantly increased. There was no decrease in other putative transmitters (dopamine, serotonin, acetyl-choline, glycine and taurine), nor was a glutamate decrease observed in the hippocampus or in the hypothalamus, which do not receive direct premotor and motor cortical inputs. Both biochemical and morphological evidence for a minor contralateral cortico-striatal projection was obtained. Correlating with the fall in glutamate, ultrastructural observations indicated the degeneration of two types of striatal synapses, i.e., those of the axo-spinous type III and of the axo-dendritic type VII. Frontal cortex ablation clearly affects, in opposite directions, the metabolism of various striatal amino acids but not that of acetylcholine and the monoamine transmitters. The results strongly support the view that glutamate is the transmitter of the cortico-striatal fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb05352.x
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  • 5
    Electronic Resource
    Electronic Resource
    Mass Fragmentographic Determination of Homovanillic Acid in Individual Dopaminergic Neuron Systems of Rat Brain: Application of Reaction Gas Chromatography (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 38 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Homovanillic acid (HVA) levels of 12 discrete rat brain areas were determined by a mass fragmentographic method using the reaction gas chromatographic technique. The use of reaction gas chromatography increased the sensitivity for determination of HVA. The sensitivity of this method allows measurement of HVA in small amounts of brain tissue. The HVA levels in polar, medial, and lateral fields of prefrontal cortex, anterior cingulate cortex, septum, amygdala, A12, A13, and A14 dopaminergic neurons were 0.417 ± 0.018 ng/mg protein, 0.689 ± 0.004, 0.753 ± 0.024, 0.496 ± 0.029, 1.311 ± 0.046, 0.555 ± 0.008, 1.949 ± 0.077, 1.109 ± 0.112, and 0.489 ± 0.019, respectively. The HVA levels in these areas are first reported in the present paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb10884.x
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  • 6
    Electronic Resource
    Electronic Resource
    Protein synthesis in vitro, in the presence of Ca(OH)2-containing pulp-capping medicaments (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 12 (1983), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Four Ca(OH)2-containing pulp-capping medicaments were compared for their effects on protein synthesis in early subcultures of monkey- and human-pulpal fibroblasts. While protein synthesis, as well as DNA synthesis, was depressed by three of the medicaments, the protein-synthetic rate in human-cell cultures in the presence of Life® rose to control levels when the medium was changed daily, but was depressed when the medium was not changed. This suggests that serum proteins play a protective role for pulpal tissues under inflammatory conditions, at least in the case of Life®, allowing odontoblasts to differentiate and make dentinal matrix without interference of either toxic components or excess alkalinity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1983.tb00348.x
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of amitriptyline on serum glutamate and free tryptophan in rats (1982)
    Springer
    European archives of psychiatry and clinical neuroscience 232 (1982), S. 391-394 
    Details
    ISSN: 1433-8491
    Keywords: Serum glutamate ; Free tryptophan ; Amitriptyline ; Depression ; Serum-Glutamat ; freies Tryptophan ; Amitriptylin ; Depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die chronische Gabe von Amitriptylin (2 Wochen, 10 mg/ kg, i.p.) führte zu einer signifikanten Zunahme von Glutamat und freiem Tryptophan im Serum von Ratten. Dagegen hatte Amitriptylin eine Wirkung weder auf das Gesamttryptophan im Serum noch auf den Glutamatgehalt des Liquors. Diese Ergebnisse bestätigen die Hypothese, daß Antidepressiva für die Zunahme des Serumglutamats bei Depressiven verantwortlich sind.
    Notes: Summary In rats, chronic amitriptyline (14 days, 10 mg/kg, IP) administration resulted in a significant increase in the serum glutamate concentration and concomitant increase in the serum free tryptophan. In contrast, amitriptyline had no effect on the total serum tryptophan or CSF glutamate level. The data confirmed that antidepressant drugs may induce an increase of the serum glutamate concentration in depressive patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345595
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  • 8
    Electronic Resource
    Electronic Resource
    Glutamat- und GABA-Konzentration in Gehirn und Liquor Cerebrospinalis von Ratten unter Behandlung mit Phosphatidylcholin (1982)
    Springer
    European archives of psychiatry and clinical neuroscience 232 (1982), S. 33-38 
    Details
    ISSN: 1433-8491
    Keywords: Phosphatidylcholine ; Glutamate ; GABA ; Brain ; CSF ; Friedreich's ataxia ; Phosphatidylcholin ; Glutamat ; GABA ; ZNS ; Liquor cerebrospinalis ; Friedreichsche Ataxie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Um zu untersuchen, ob die Gabe von Phosphatidylcholin, die den zentralnervösen Azetylcholingehalt erhöht, einen Einfluß auf die Neurotransmitter Glutamat und GABA hat, wurde 17 von 32 Ratten über 14 Tage 1,5g/kg Lethicon® pro die peroral gegeben. Die fluorometrische Messung der Konzentrationen von Glutamat und GABA in frontalem Cortex, Striatum, Nigra, Kleinhirnrinde sowie von Glutamat im Liquor cerebrospinalis ließ keine signifikanten Unterschiede gegenüber Kontrolltieren erkennen. Nach zweiwöchiger Gabe von Phosphatidylcholin konnte keine zentralnervöse Interaktion des cholinergen Systems mit den Neurotransmittern Glutamat und GABA nachgewiesen werden.
    Notes: Summary Phosphatidylcholine increases CNS concentrations of acetylcholine. In rats we investigated whether or not phosphatidylcholine also influences the neurotransmitters glutamate and GABA. In 17 rats 1.5g/kg Lethicon perorally was administered daily for 2 weeks, 15 rats served as controls. In tissue from frontal cortex, striatum, substantia nigra, cerebellar cortex no significant differences between treated and untreated animals were found in glutamate or GABA concentrations. A central nervous interaction between the cholinergic system and the neurotransmitters glutamate and GABA, therefore, could not be demonstrated after 2 weeks of phosphatidylcholine intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00343363
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  • 9
    Electronic Resource
    Electronic Resource
    Reduction of cerebrospinal fluid glutamic acid in huntington's chorea and in schizophrenic patients (1980)
    Springer
    European archives of psychiatry and clinical neuroscience 228 (1980), S. 7-10 
    Details
    ISSN: 1433-8491
    Keywords: Huntington's chorea ; Schizophrenia ; Glutamic acid ; Cerebrospinal fluid ; Neuroleptic therapy ; Huntington-Chorea ; Schizophrenie ; Glutaminsäure ; Liquor ; Neuroleptische Behandlung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Liquor von drei Patienten-Gruppen mit Huntington-Chorea, Schizophrenie und Bandscheibenvorfällen wurde der Glutaminsäuregehalt bestimmt. Im Liquor der Huntington-Patienten und der Schizophrenen war die Glutaminsäure fast auf die Hälfte erniedrigt im Vergleich zu den Kontrollen mit Bandscheibenvorfällen. Der Glutaminsäuregehalt des Blutserums war bei allen drei Gruppen gleich hoch. Die meisten Huntington- und Schizophrenie-Patienten standen unter neuroleptischer Behandlung, nur eine Tochter eines Huntington-Patienten, bei der die Krankheit noch nicht manifest war, zeigte ebenfalls eine Glutaminsäureverminderung im Liquor. Da diese Patientin keine neuroleptischen Medikamente erhielt, ist es wahrscheinlicher, daß die Glutaminsäureverminderung durch die Erkrankung und nicht durch die neuroleptische Behandlung verursacht ist.
    Notes: Summary Glutamic acid levels were investigated in the cerebrospinal fluid and blood serum of patients with schizophrenia, Huntington's chorea, and sciatic nerve compression by lumbar disc protrusion. In the serum the glutamic acid levels were equal in all three groups; in the cerebrospinal fluid (CSF) of schizophrenic and Huntington's patients, however, the glutamic acid was decreased to almost half that of the lumbar disc group which served as control. Most of the patients were treated with neuroleptic drugs. However, since in one case (the daughter of a Huntington's patient) the CSF glutamic acid was decreased although this woman had had no neuroleptic treatment, it seems more likely that the glutamic acid decrease is due to the disease rather than to the neuroleptic treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365738
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  • 10
    Electronic Resource
    Electronic Resource
    Der Einfluß von Viren auf Megakaryozyten in vitro (1981)
    Springer
    Annals of hematology 42 (1981), S. 33-39 
    Details
    ISSN: 1432-0584
    Keywords: Megakaryocytes ; Bone marrow cultures ; Adenovirus ; Herpes simplex virus ; Vaccinia virus ; Newcastle disease virus ; Megakaryozyten ; Knochenmarkskultur ; Adenovirus ; Herpes simplex-Virus ; Vacciniavirus ; Newcastle disease-Virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Knochenmarks-Suspensionen von jungen Ratten enthalten 0,3% Megakaryozyten. Dieser Anteil geht innerhalb von 72–96 h nach Kultivierung in vitro in Leighton-Röhrchen infolge Thrombozytopoese fast auf 0 zurück. Solche Kulturen wurden unmittelbar nach dem Anlegen mit verschiedenen Viren in hoher Multiplizität beimpft. Nach Infektion mit Herpes simplex-Virus Typ 1 oder Adenovirus Typ 2 zeigten die Megakaryozyten in den folgenden Tagen kein abweichendes Verhalten an Zahl und Morphologie gegenüber den Kontrollen. Dagegen wiesen die Kulturen nach Infektion mit Vacciniavirus und noch ausgeprägter mit Newcastle disease-Virus morphologische Veränderungen der Megakaryozyten mit Störung der Thrombozytopoese auf. Auch persistierten die veränderten Megakaryozyten in beträchtlichem Prozentsatz über 72–96 h. Schließlich war nach Infektion mit Vacciniavirus und NDV, jedoch nicht mit HSV1 oder Adenovirus 2, eine spezifische Immunfluoreszenz im Zytoplasma der Megakaryozyten mit antiviralen Antiseren nachweisbar. Dies spricht für eine direkte Zellschädigung mit Vermehrung des Virus in den Megakaryozyten bei Vacciniavirus und NDV.
    Notes: Summary Bone marrow suspensions from adolescent rats contain 0.3% megakaryocytes; this rate decreases to almost zero within 72–96 h cultivation in vitro in Leighton tubes because of thrombocytopoesis. Such cultures were inoculated immediately after seeding with different viruses in high multiplicity. After infection with herpes simplex virus type 1 or adenovirus type 2, no deviation of the number and morphology of the megakaryocytes was seen when compared with control cultures. However, after infection with vaccinia virus and, still more marked, with Newcastle disease virus, morphological alterations and interference with thrombocytopoesis were seen. Furthermore, a considerable portion of the altered megakaryocytes persisted for 72–96 h. Finally, the cytoplasm of the megakaryocytes after infection with vaccinia virus or NDV, but not with HSV1 or adenovirus 2, showed a specific immunofluorescence with antiviral antisera, which indicates a direct cellular involvement and multiplication of vaccinia virus and NDV in megakaryocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01080262
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