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  • 1
    Electronic Resource
    Electronic Resource
    Prelunularic acid, a probable immediate precursor of lunularic acid. First example of a "prearomatic" intermediate in the phenylpropanoid-polymalonate pathway (1983)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 105 (1983), S. 4480-4481 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00351a062
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  • 2
    Electronic Resource
    Electronic Resource
    A highly predictable animal model of retinoblastoma (1982)
    Springer
    Acta neuropathologica 57 (1982), S. 203-208 
    Details
    ISSN: 1432-0533
    Keywords: Animal model ; Human adenovirus serotype 12 ; Retinal tumor cell line ; Syngeneic CDF rat ; T-antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new animal model of retinoblastoma was developed in newborn inbred CDF rats by intravitreous inoculation of retinal tumor cells (5×104/5 μl) derived from the cultured tumor cell line EXP-5. The retinal tumor from which the cell line originated was induced by a single intravitreous inoculation of human adenovirus serotype 12 (5 μl of 108 TCID 50/0.1 ml) in syngeneic rats. Within 1 month after intravitreous moculation of EXP-5 cells, a clinically recognizable ocular tumor was obtained in all 39 rats. Ad 12-specific T-antigens were demonstrated in the cultured tumor cells using immunofluorescent techniques. Morphologically these tumor cells closely resembled retinoblastuma, with poorly differentiated intracytoplasmic organelles, solitary cilia with a 9+0 tubule pattern, and abnormal nuclear membrane associated with a set of basal bodies. The significance of this highly manipulable retinal tumor cell line is the capability of providing a full-fledged intravitreous tumor in 1-month-old CDF rats, whose actual life span is known to be 42 months. Transplantable retinal tumors described to date are reviewed breifly and compared with the presently reported cell line.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685390
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  • 3
    Electronic Resource
    Electronic Resource
    Semisynthesis and biological properties of the [B24-leucine]-, [B25-leucine]- and [B24-leucine, B25-leucine]-analogues of human insulin (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 811-813 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Trypsin-catalyzed coupling of porcine desoctapeptide-insulin with synthetic octapeptides produced the [LeuB24]-(I), [LeuB25]- (II) and [LeuB24, LeuB25]- (III)analogues of human insulin. I, II and III displayed respectively 20–30%, 1–2% and 0.5% of the receptor binding activity of the normal hormone. Biological activities of these analogues seemed to be proportional to their binding potencies when assayed in vitro, while in an in vivo assay analogue I was fully active and II exhibited 10–20% of normal activity. III was less active than II in all assays tested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01985653
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  • 4
    Electronic Resource
    Electronic Resource
    Poly(isothianaphthene) (1984)
    s.l. : American Chemical Society
    The @journal of organic chemistry 49 (1984), S. 3382-3384 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00192a027
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  • 5
    Electronic Resource
    Electronic Resource
    New in vitro method for detecting asthma allergen (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 13 (1983), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Changes in the morphology and number of basophils were examined after the addition in vitro of house dust extract in cells from seventy-seven patients with bronchial asthma. Morphological changes (reactive basophils) showed a close relation to the end-point titrations of antigen in skin tests, RAST score and bronchial provocation tests, but changes in number of basophils did not. With a RAST score of 2 or greater the change in reactive basophils varied from 40 to 80% (mean 58-1%), which was much greater than seen in persons with no RAST, score 0. Patients with positive bronchial inhalation tests, showed 40 to 80% (mean 57.8%) reactive basophils, whereas persons with a negative bronchial challenge test showed a range of reactive basophils from 0 to 50% (mean 28.9%). The difference in percentage of reactive basophils between the positive and negative groups of persons tested by bronchial inhalation was statistically significant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1983.tb02576.x
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  • 6
    Electronic Resource
    Electronic Resource
    DIFFERENTIAL CHRONOTROPIC AND INOTROPIC EFFECTS OF 2-NICOTINAMIDOETHYL NITRATE (SG-75) IN THE DOG ISOLATED ATRIUM (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 7 (1980), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The chronotropic and inotropic effects of the anti-anginal agent SG-75 (2-nicotinamidoethyl nitrate) and 1-verapamil were investigated in isolated blood-perfused canine atrial preparations. The compounds were administered via the cannulated sinus node artery.2. SG-75 induced a selective negative inotropic as opposed to a chronotropic effect. Verapamil showed no selective negative chronotropic or inotropic activity.3. Effects of SG-75 and 1-verapamil on the frequency-force relationship were studied. SG-75 produced a uniform depression of the developed tension at all frequencies tested which the depression with 1-verapamil was greater at higher than at lower frequencies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1980.tb00062.x
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  • 7
    Electronic Resource
    Electronic Resource
    Second harmonic generation in inclusion complexes (1984)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 2 (1984), S. 885-890 
    Details
    ISSN: 1573-1111
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Second harmonic generation (S.H.G.) in inclusion complexes between dimethyl β-cyclodextrin (dimethyl β-CD) and nitroaniline derivatives occurs. This is due to the destruction of the centrosymmtric crystal structure in nitroaniline derivatives caused by forming inclusion complexes. S.H.G. intensity of dimethyl β-CD complex with N-methyl-nitroaniline is 5.5 times as large as that of urea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662258
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  • 8
    Electronic Resource
    Electronic Resource
    Alterations in neutral amino acid transport across the blood-brain barrier in hepatic failure (1983)
    Springer
    Research in experimental medicine 183 (1983), S. 11-18 
    Details
    ISSN: 1433-8580
    Keywords: Blood-brain barrier ; Neutral amino acid ; Hepatic failure ; Amino acid transport into the brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The accelerated transport of the blood neutral amino acids into the brain in encephalopathic patients with fulminant hepatitis and advanced liver cirrhosis was demonstrated not only by determining the cerebrospinal fluid (CSF) aminogram but also by calculating the predicted velocity of the amino acid transport through the blood-brain barrier. Significant elevation in CSF aromatic amino acid (AAA) and methionine levels was observed in the encephalopathic patients. Arousal from hepatic encephalopathy by drip infusion of a branched chain amino acid (BCAA)-enriched solution was obtained coincidentally with the elevated BCAA levels and diminished concentrations of AAA and methionine in CSF. These clinical observations were confirmed experimentally in rats treated with carbon tetrachloride (CCl4) andd-galactosamine by obtaining the elevation of neutral amino acid contents in the brain and the slight increase in the brain uptake index (BUI) of a radiolabeled amino acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851759
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of prostaglandin on urethral resistance and micturition (1983)
    Springer
    Urological research 11 (1983), S. 19-22 
    Details
    ISSN: 1434-0879
    Keywords: Prostaglandin ; Urethral resistance ; Micturition ; Urodynamics ; Dog experiment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of four exogenous prostaglandins, PGA1, PG802, PGE2 and PGF2α, upon the lower urinary tract was investigated in female mongrel dogs without neurogenic lesions in vivo. The urethral resistance was studied by means of a urethral pressure profile, and the bladder function by evaluating whether or not the micturition was triggered. The reduction of urethral resistance in terms of the maximum urethral closure pressure was most significant with PGE2 given intraarterially. Micturition was most frequently provoked by the intravenous administration of PG802, a derivative of PGE1. PGE series seemed to be the most potent for the evacuation of urine in female dogs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00272704
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  • 10
    Electronic Resource
    Electronic Resource
    Chemical effect on FKα X-ray satellites produced by 6 MeV/amu p,α and C4+ (1981)
    Springer
    The European physical journal 300 (1981), S. 1-6 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The excitation conditions where both direct Coulomb and shake-off processes concur to multiply ionize fluorineK andL shells were adopted in this experiment; 6MeV/amu p,α and C4+ impacts. The ion induced FKα satellites, measured for a series of F bearing compounds, showed significant chemical effects on their intensity distributions. Such effects are explained well with an FL-vacancy rearrangement model. Without any theoretical prediction, rearrangement probabilities or widths of FL shells were estimated by use of a reference compound with high ionicity, i.e. NaF. A linear relationship between FL widths and covalencies of compounds was found for a wide variety of fluorides. For the same compounds, the absolute values of the FL-vacancy rearrangement probabilities or the FL-shell widths obtained here were the same as those estimated from pure direct Coulomb and pure shake-off excitations, respectively. Other models than theL-vacancy rearrangement's are also discussed and eliminated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412608
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