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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 8 (1981), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Blood pressure decreased significantly at a late stage of pregnancy in spontaneously hypertensive rats (SHRs) but this reduction tended to disappear shortly after delivery. Since acute and chronic administration of progesterone, prolactin and estrone failed to reduce blood pressure, these hormones were not responsible for a fall of blood pressure at a late stage of pregnancy in SHRs. Exogenous administration of prostaglandin E2 (PGE2) significantly reduced blood pressure, but endogenous prostaglandin E1 (PGE1), PGE2 and prostaglandin F2α(PGF2α) in plasma did not increase at a late stage of pregnancy.2. Plasma from pregnant SHRs produced a significant reduction of blood pressure in male and female SHRs, but the plasma from male and non-pregnant female SHRs failed to reduce blood pressure. Plasmas from pregnant SHRs were less effective in reducing blood pressure when tested in Wistar Kyoto rats (WKYs).3. It is concluded that a hypotensive factor is circulating at a late stage of pregnancy in SHRs.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 21 (1983), S. 664-673 
    ISSN: 1741-0444
    Keywords: Clinical assessment ; Data processing ; Foot force ; Locomotion disability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A real need has existed for the development of simple, inexpensive, and yet functionally significant gait assessment systems that could be used in clinical practice. The paper describes a new scheme for the data processing of the output of a simple foot force measuring device previously reported by the authors. Only vertical forces exerted on the forefoot and the heel are measured continuously by the device. From these signals, the muscle moment acting on the ankle, the centre of pressure in one foot and the centre of pressure between both feet are calculated. Thus information on the muscle activities at the ankle and on the transfer of body weight in the progressional direction is derived. A brief description of the mathematical background is given first, and the clinical relevance of this method is discussed with several illustrations of preliminary results on normal and pathological subjects.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 22 (1984), S. 70-76 
    ISSN: 1741-0444
    Keywords: Correlation analysis ; Gait analysis ; Gait evaluation ; Pathological gait ; Quantitative indices
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Although various methods have been proposed for quantitative evaluation of pathological gait, they are not yet widely used as routine clinical tools. The reasons are that measuring systems are too expensive and complicated and that the validity of the methods has not been fully examined in a statistical manner. In this paper, the validity of a new evaluation method based on a simple foot-force measuring device is investigated in terms of the correlation between quantitative indices and visually-rated grades. Forty-eight hemiparetic patients secondary to cerebral vascular accident walked on a 15 m straight level floor. Four people independently evaluated each subject in eight gait characteristics or items on a scale of 1–4 grades on the basis of visual inspection. These items include symmetry, variation, fluctuation, and dependence on the cane. At the same time, the vertical ground-reaction forces exerted on the right and left feet and on the cane were measured, and then quantitative indices representing these eight items were derived. All but one index shows a reasonably good correlation with the mean of the grades of the four observers. Thus, the feasibility of these indices is demonstrated. Statistical analysis also reveals several problems inherent in visual rating, such as inconsistency in the interpretation of evaluation criteria among observers, and a degradation of the independence of items owing to the observer’s subjectivity.
    Type of Medium: Electronic Resource
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