ISSN:
1432-069X
Keywords:
Phototoxicity
;
Benoxaprofen
;
Photohemolysis
;
Mouse-tail technique
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Benoxaprofen (BP), a non-steroidal antiphlogistic drug causing skin and nail photoreactions, has been evaluated for photoactivity using three experimental techniques. In vivo in the mouse, BP was phototoxic in doses of 25 mg/kg in combination with UV-A 54 J. The phototoxic potency could be confirmed in vitro with the Candida albicans test. In vitro, using photohemolysis, BP showed a dose-dependent activity causing 40% hemolysis at a concentration of about 25 μg/ml with UV-a. Also, small UV-B doses caused red cell lysis with a moderate BP concentration. Preirradiation experiments showed that UV-A, but not UV-B, photoproducts could account for some of the activity. The action spectrum of BP photoactivity lies mainly in the UV-A, but may also extend into UV-B. Compared with chlorpromazine in vivo and in vitro, and with doxycycline in vivo, BP showed intermediate phototoxic activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00417205
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