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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 24 (1983), S. 387-390 
    ISSN: 1432-0428
    Keywords: Crosslinking ; disuccinimidyl suberate ; insulin receptor ; anti-receptor antibody ; immunoprecipitation ; type B syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 125I-insulin was covalently crosslinked to its receptor on human placental membrane fractions with disuccinimidyl suberate. The 125I-insulin crosslinked receptor was solubilized with Triton X-100 and used as a probe to determine autoantibodies to the insulin receptor in sera from patients with insulin resistance (type B syndrome). When the solubilized 125I-insulin: receptor complex was incubated with these sera and then with anti-human IgG serum, the complex was precipitated as a function of the amount of anti-receptor serum. Unlabelled insulin at concentrations ⩽10 μg/ml did not affect immunoprecipitation of the complex, suggesting that a subpopulation of anti-receptor antibodies recognizes determinants outside the insulin binding region of the receptor molecule. 125I-insulin: receptor complex was precipitated also by the addition of anti-insulin antibodies. The effect of anti-insulin antibody was eliminated by the addition of excess unlabelled insulin. The immunoprecipitation assay using 125I-insulin crosslinked receptor was sensitive and convenient for detecting anti-receptor antibodies.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 38 (1982), S. 140-141 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A treadmill was improved so as to eliminate foot and tail injuries in small test-animals. The improvement was inexpensive and easily fabricated by the researchers.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 17 (1981), S. 1697-1716 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A finite element method with transmitting boundary is developed for time-harmonic elastodynamics on infinite domains. Only a finite inner domain needs to be discretized into conventional finite elements, while the effect of the exterior domain is simulated by introducing the transmitting boundary stiffness matrix on the degrees-of-freedom of the transmitting boundary nodes. In order to incorporate the Sommerfeld radiation condition, the reciprocity relation, on the transmitting boundary for the radiating elastodynamic state under consideration and the one which is induced by a finite number of point source is used to calculate the transmitting boundary stiffness matrix. The effectiveness of the transmitting boundary technique has been demonstrated by solving the stress concentration problems of a homogeneous isotropic full space with a circular cylindrical cavity and of the one with a spherical cavity, which are subjected to plane incident waves, and the results are compared with the ones of the conventional FEM and the exact data.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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