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  • 1
    ISSN: 1432-1106
    Keywords: Dorsal column nuclei ; Gracile nucleus ; Primary sensory neuron ; Dorsal horn ; Glia ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The time course of the microglial cell reaction in central nervous system primary sensory projection territories has been examined following peripheral nerve injury in the adult rat using qualitative and quantitative analysis of immunoreactivity with the monoclonal antibody OX-42, which recognises the complement receptor CR3. The regions examined included the gracile nucleus, the column of Clarke and the spinal cord dorsal horn (superficial and deep laminae separately) after unilateral sciatic nerve transection, and the spinal trigeminal nucleus following unilateral infraorbital nerve transection. In all territories examined a qualitative increase in OX-42 immunoreactivity was observed 24 h postlesion. Further, quantitative analysis revealed an exponential development of the OX-42 immunoreactivity, with a peak at one week postlesion, thereafter showing a slow exponential decline. Our results show that the signal (or signals) that induces the microglial cell response in primary sensory projection territories is rapid in comparison to previously described central degenerative changes following peripheral nerve lesions (transganglionic degeneration). These findings are compatible with the hypothesis that activated microglia play a pathogenetic role in the development of transganglionic degeneration.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-6327
    Keywords: Cardiac performance ; Circadian rhythm ; Shift work
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Circadian variations of the pre-ejection period, Q-T interval, heart rate and oral temperature at rest and in day and night shift work were investigated. At rest, pronounced circadian variation was found in heart rate, pre-ejection period and Q-T interval. The ratio between Q-T interval and heart rate also shows a distinct circadian variation. When working, the rest rhythms of the variables were obscured. The physiological implications for shift work are discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 50 (1983), S. 179-193 
    ISSN: 1439-6327
    Keywords: Static exercise ; Fatigue ; Electromyography ; Circulation ; Perceived effort
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The development of fatigue and the relationship between psychological and physiological indices of fatigue were studied in a group of 18 male subjects during static contractions. Exercise was performed as a static elbow flexion at 25% MVC. Heart rate (HR), intraarterial blood pressure (BP) and surface EMG [mean amplitude (MA) and central frequency (CF)] were studied during contractions sustained until exhaustion. The amount of effort expended (relative to total exhaustion) and the rating of perceived pain were recorded following contractions interrupted after 20, 30 ⋯ 80, and 100% of endurance time. HR, BP and EMG amplitude responses were similar to those previously recorded. The decline in CF occurred in two phases, possibly related to a change in motor unit recruitment after the initial 70% of endurance time. The subjects overestimated the amount of effort expended and thus underestimated their endurance capacity. The best correlation between perceived effort and physiological responses was obtained using blood pressure data, whereas changes in EMG data did not parallell the psychological responses. It is concluded that the perception of effort during a static contraction is produced through a complex process, in which several influences of peripheral and central origin are integrated.
    Type of Medium: Electronic Resource
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