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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 25 (1981), S. 133-142 
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract VLF (Very Low Frequencies)-fields are damped electromagnetic waves of atmospheric origin (sferics). Sferics were artificially produced within a steel-built chamber; blood was drawn and platelet adhesiveness, platelet cyclic AMP and coagulation factors were measured in human volunteers placed within the chamber. Following frequency of the impulses of 10 Hz and a field strength of 400 mV/m increased platelet adhesiveness and decreased platelet cyclic AMP. Medication of the anti-platelet drugs were not effective at all, but the pretreatment of dipyridamole 75 mg combined with acetylsalicylic acid 100 mg blocked the sferics induced increment in platelet adhesiveness. Psychologically labile volunteers exhibited more marked effects of sferics upon platelet adhesiveness. Simulation of stressors upon platelets showed the same effect. The increase in platelet adhesiveness induced by all kind of stressors is not a risk factor of thrombosis in itself. Only if the vessel walls are damaged, e.g. by atherosclerotic plaques, or if the blood flow is reduced, e.g. by heart failure, then the increased platelet adhesiveness will cause thrombosis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 138 (1982), S. 49-52 
    ISSN: 1432-1076
    Keywords: Kinetics ; Translactal passage ; Digoxin ; Breastfed infants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to find out whether digoxin therapy of nursing mothers might produce discomfort in suckling infants we have investigated the kinetics of the transfer of digoxin from plasma to milk in 11 nursing mothers. After intravenous or oral application of a single dose of 0.5 mg or 0.75 mg digoxin simultaneous serum, fore- and hindmilk samples were taken. Obviously, a rapid equilibrium occurred between the serum and the milk compartments and there was no difference between fore- and hindmilk. All three digoxin concentration profiles ran parallel with a milk to serum ratio of 0.6 to 0.7. The curves could best be fitted by the sum of two exponential functions. For predicting the digoxin intake into the suckling infant, simulations were carried out on the basis of two coupled compartment models. When the kinetic milk data as well as the kinetic data obtained in infants were fitted by this model it could be shown that even in the case of long half-lives only about 3% of the therapeutic drug levels were reached in the baby. Thus, one can conclude that digoxin accumulation to toxic concentrations should not occur in infants of women treated with appropriate doses of digoxin.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 138 (1982), S. 285-285 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 87 (1981), S. 267-274 
    ISSN: 1437-1596
    Keywords: HLA-typing of cadavers ; Estimation of the time of death, HLA-typing ; Cornea transplantation, HLA-typing ; HLA-Typisierung von Leichen ; Todeszeitbestimmung, HLA-Typisierung ; Corneatransplantation, HLA-Typisierung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung An menschlichen wie tierischen Leichen wurden Untersuchungen zur Kinetik des frühen postmortalen Zerfalls der Lymphozyten-membran durchgeführt. Es ergab sich, daß direkte HLA-Typisierungen an Leichen innerhalb von 36 h nach dem Tode möglich sind, sofern die Umgebungstemperaturen unter 10°C gelegen haben. Man erhält hierdurch die Möglichkeit, HLA-ABC Antigene zu forensischen Zwecken und für Cornea-Transplantationen zu bestimmen. Die tierexperimentellen Studien lieferten den Hinweis, daß der Zerfall der Lymphozyten nach den Gesetzmäßigkeiten der Verhultschen Gleichung verläuft. Bei Gebrauch dieser Funktion ist eine Möglichkeit gegeben, die Zerfallskonstante als Funktion der Temperatur zu messen, womit eine Todeszeit-Bestimmung versucht werden kann.
    Notes: Summary Tests on human and animal cadavers were carried out to investigate the early postmortem decay of the lymphocyte membrane. HLA-typing of cool-kept human cadavers can be performed within the first 36 h after death. Hereby, a possibility is obtained to determine HLA-ABC antigens of a deceased for hemogenetic or cornea transplantation purposes. The data obtained from animal experiments give evidence that the decay of the lymphocyte membrane follows a function of the Verhult's type. Using this function, it is possible to estimate the rate constant as a function of temperature.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-926X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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