ISSN:
1573-1111
Keywords:
Prednisolone
;
β- and γ-cyclodextrins
;
inclusion complex
;
dissolution
;
membrane permeation
;
suppository release
;
oral and rectal absorption
;
rabbit
;
serum level
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Inclusion complexes of prednisolone with β- and γ-cyclodextrins in the molar ratio of 1:2 and 2:3, respectively, were prepared, and their dissolutions, permeations through a cellophane membrane, releases from a suppository base, andin vivo absorption behaviors were examined. The apparent rates of dissolution and permeation of prednisolone were significantly increased by the formations of inclusion complexes with β- and γ-cyclodextrins. The release of the drug from Witepsol H15 suppositories was also increased by complexation. The serum levels of prednisolone following oral and rectal administrations of the cyclodextrin complexes to rabbits were higher than those of the drug alone. The enhanced initial absorption of prednisolone by cyclodextrin complexation suggested the possibility of smaller doses in prednisolone therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00665481
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