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  • 1
    Electronic Resource
    Electronic Resource
    On the Biochemical Nature of the ‘Sm’ Nucleoplasmic Antigen (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 13 (1981), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The nucleoplasmic autoantigen RNP and Sm are of particular interest because of their association with cerium symptoms of mixed connective tissue disease and systemic lupas erythematosus. The RNP is generally thought to be a ribonucleoprotein and there is evidence that its RNA may be single-Stranded Experiments presented in this report are in support of the concept that the Sm-antigen may also be an RNA protein. Purified Sm anti-Sm precipitates were shown to have high RNA contents and treatment Of Sm-antigen with RNAse in a hypotonic medium strongly reduced its antigenicity. The latter effect indicates that the Sm-antigen may in contrast to the RNP contain double-stranded RNA, a possibility also suggested by the finding that the Sm-antigen in soluble in 2m LiCl. The Sm-antigen was found further to differ from RNP in being selectively absorbent on BD-Sephadex, while RNP remained active in the supernatant. Cytochemical studies Involving stimulation and Inhibition experiments with lectins and RNA polymerase inhibitors showed that the Sm-antigen was, in distinction to RNP, sensitive to rifampicin but not to α-amanitine. Tins suggests that the RNAs of the nucleoplasmic antigens may be synthesized by different RNA polymerases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1981.tb00123.x
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  • 2
    Electronic Resource
    Electronic Resource
    298. Die Pfortaderarterialisation nach portocavalem Shunt —Ein experimentelles Programm an der Ratte (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 607-608 
    Details
    ISSN: 1435-2451
    Keywords: Portacaval shunt ; Arterialization ; Experimental cirrhosis ; Liver atrophy ; Portocavaler Shunt ; Arterialisation ; Experimentelle Cirrhose ; Leberatrophie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der End-zu-Seit-portocavale Shunt ist bei portaler Hypertension noch immer wertvoll. Um die dadurch bedingte Reduktion der Lebergesamtperfusion zu verhindern, ist eine zusätzliche Arterialisation des Pfortaderstumpfes möglich. Die meisten Ergebnisse anderer Autoren sind widersprüchlich. Deshalb haben wir ein neues, Flow-adaptiertes Modell der Arterialisation an der gesunden und Thioazetamid-cirrhotischen Ratte (900 Operationen) untersucht. Durch die Arterialisation werden die Abnahme des Körpergewichtes, die Leberatrophie und die Abnahme der enzymatischen intrinsic activity des Lebergewebes verhindert.
    Notes: Summary The end-to-side portacaval shunt is still valid in cases of portal hypertension. In order to prevent the reduction of total liver perfusion induced thereby, an additional arterialization of the portal stump is possible. Most (experimental) results of other authors are contradictory. Therefore we have established a new model of flow-adapted arterialization in the healthy and thioacetamide-cirrhotic rat (about 900 operated rats). Decrease of body weight, liver atrophy and decrease of intrinsic (enzymatic) activity of liver tissue is prevented by additional arterialization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292263
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    Paper (German National Licenses)
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