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  • 1
    Electronic Resource
    Electronic Resource
    Oxolinic acid and diazepam: Their reciprocal antagonism in rodents (1980)
    Springer
    Psychopharmacology 67 (1980), S. 91-95 
    Details
    ISSN: 1432-2072
    Keywords: Oxolinic acid ; Diazepam ; GABA ; Stereotyped behavior ; Locomotor stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The stimulant effects of oxolinic acid were investigated in rats and mice. This drug, given orally, consistantly induced, in doses ranging from 16 to 256 mg·kg-1, locomotor stimulation and stereotyped behavior. These effects were antagonized by pimozide (1 mg·kg-1), α-methyltyrosine (64 mg·kg-1) or reserpine (4 mg·kg-1, 24 h before testing) pretreatment, suggesting a facilitatory role of oxolinic acid on catecholaminergic processes. Diazepam (4–16 mg·kg-1) reduced the stimulant effects induced by oxolinic acid but not those induced by amphetamine; oxolinic acid (8 mg·kg-1) markedly reduced the antipunishment effect elicited in rats by diazepam (2 mg·kg-1). Since benzodiazepines have been reported to enhance GABA functioning, these data suggest that oxolinic acid may impair GABA transmission. However, neither muscimol (0.5–1 mg·kg-1) or γ-acetylenic-GABA (16–64 mg·kg-1) selectively reduced the stimulant effects elicited by oxolinic acid. Therefore, the possible facilitation exerted by this drug on catecholaminergic systems may not derive from the release of an inhibitory GABAergic control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427601
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence against the involvement of serotonergic neurons in the anti-punishment activity of diazepam in the rat (1984)
    Springer
    Psychopharmacology 82 (1984), S. 355-359 
    Details
    ISSN: 1432-2072
    Keywords: Punishment-induced suppression ; Diazepam ; Serotonin ; Dorsal raphé ; Substantia nigra ; 5,7-Dihydroxytryptamine ; Ro 15-1788 ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of manipulating central serotonergic transmission were assessed on the anti-punishment effects of diazepam (2 mg/kg IP) in rats. In a paradigm involving the inhibition of pressing for food induced by the delivery of a signal previously associated with electric foot-shocks, lesioning serotonergic neurons of the dorsal raphé with the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT; 1 μg in 0.4 μl) neither affected behavioral inhibition in control rats nor modified the ability of diazepam to release responding. Furthermore, suppression of pressing for food induced by a fixed ratio 7 schedule of shock presentation was reduced by bilateral infusion of 5,7-DHT (2 μg in 0.5 μl) into the substantia nigra, but the ability of diazepam to increase punished responding was preserved. Finally, blockade of benzodiazepine-induced decrease in serotonin release by application of the benzodiazepine receptor antagonist Ro 15-1788 (10−5–10−4 M in 0.2 μl) into the dorsal raphé did not alter the releasing effect of diazepam on suppression of pressing for food caused by a signal of punishment. At these concentrations. Ro 15-1788 was devoid of any effect on behavioral inhibition in control rats. Taken together, these results indicate that the anti-punishment activity of benzodiazepines can be dissociated from the reduction in tryptaminergic transmission produced by these drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427685
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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