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  • 1
    Electronic Resource
    Electronic Resource
    Topographic distribution pattern of Lafora-like bodies in the spinal cord of some animals (1980)
    Springer
    Acta neuropathologica 49 (1980), S. 159-161 
    Details
    ISSN: 1432-0533
    Keywords: Lafora-like bodies ; Spinal cord ; Animals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The topographic distribution pattern and morphological features of Lafora-like bodies in the spinal cord of the dog, cat, fox, and baboon were examined by light and electron microscopy. The caudal lumbar and the coccygeal parts of the spinal cords were the predilection sites for the bodies in all animals and were very prominent in the ventral columns and intermediate substance. The bodies mainly composed of branching filaments were preferentially located in neuronal processes and rarely in astrocytes. The histochemical characteristics of the bodies were identical in all animals and consisted mainly of polyglucosan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690756
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  • 2
    Electronic Resource
    Electronic Resource
    Retinal amacrine cell involvement in Tay-Sachs disease (1981)
    Springer
    Acta neuropathologica 53 (1981), S. 333-336 
    Details
    ISSN: 1432-0533
    Keywords: Amacrine cell ; Tay-Sachs disease ; Ultrastructure ; Biochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural study of the retina from a patient with Tay-Sachs disease disclosed that amacrine cells as well as ganglion cells were loaded with numerous membranous cytoplasmic bodies, suggesting an accumulation of GM2 ganglioside, whereas the horizontal cells, bipolar cells, and photoreceptor cells were intact. Chromatography of lipids from the retina showed a prominent spot of GM2 ganglioside. These facts suggest that lipid metabolism in amacrine cells may be different from that in other retinal cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690376
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  • 3
    Electronic Resource
    Electronic Resource
    Polyglucosan bodies in the digestive tract of the aged dog (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 297-300 
    Details
    ISSN: 1432-0533
    Keywords: Polyglucosan bodies ; Lafora-like bodies ; Aging ; Smooth muscles ; Digestive tract ; Dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In our recent studies on aging phenomena in animals, polyglucosan bodies (PGB) were found within the smooth muscle in the digestive tract of aged dogs without neurologic signs. PGB were basophilic, round, or oval bodies which appeared to have a homogenous or concentric shape. Their histochemical properties were characterized by the presence of glucose polymers (polyglucosan). Electron microscopy revealed that PGB were composed mainly of irregularly clustered, short branching filaments measuring about 90 Å in width. PGB were histochemically and ultrastructurally identical to the previously reported Lafora-like bodies in the CNS of aged dogs. PGB were found in all aged dogs and were disseminated throughout the digestive tract, especially in the cecum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691880
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  • 4
    Electronic Resource
    Electronic Resource
    Errata (1984)
    Springer
    The journal of membrane biology 80 (1984), S. 271-271 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01868445
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  • 5
    Electronic Resource
    Electronic Resource
    Infrared absorption enhancement of monolayer species on thin evaporated Ag films by use of a Kretschmann configuration: Evidence for two types of enhanced surface electric fields (1984)
    Springer
    Applied physics 35 (1984), S. 135-140 
    Details
    ISSN: 1432-0630
    Keywords: 68 ; 78
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Infrared absorption enhancement of m- and p-nitrobenzoic acid deposited on thin-evaporated silver films has been investigated using the Kretschmann's ATR coupling method. The absorption spectra provide direct evidence that enhancement is prominent only for vibrations of the first monolayer adsorbed on the Ag surface. It is shown that all of the vibrational modes observed obey the normal dipole selection rule. Moreover, it was found that there exist two types of absorption enhancement; the first is enhanced (∼300) by both p- and s-polarized radiation, and the second is enhanced (∼60) by p-polarized radiation alone. The Ag film thickness optimum is about 50 Å in the former case and about 200 Å in the latter. The enhancement insensitive to the polarization state of radiation can well be explained by the excitation of the transverse collective electron resonance of the Ag islands, whereas that obtained by p-polarized radiation may be due to the excitation of delocalized surface plasmons modified by surface roughness. The image-dipole effect may also be significant in the mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00616965
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  • 6
    Electronic Resource
    Electronic Resource
    Lithium isotope separation by laser (1982)
    Springer
    Applied physics 28 (1982), S. 73-76 
    Details
    ISSN: 1432-0649
    Keywords: 35
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A lithium isotope separation was performed using a laser isotope separation method. It was found that the lithium atoms with a natural isotopic abundance enhanced its6Li concentration up to over 90% by tuning the laser wavelength to the2 P 1/2 of6Li. Too high power, however, leads to a loss of enrichment due to the power broadening effect which was analysed by the equation of motion of density matrices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00693895
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  • 7
    Electronic Resource
    Electronic Resource
    Abnormal copper metabolism in menkes cultured fibroblasts (1980)
    Springer
    European journal of pediatrics 134 (1980), S. 205-210 
    Details
    ISSN: 1432-1076
    Keywords: Menkes kinky hair syndrome ; Menkes fibroblasts ; Copper metabolism ; Metalloprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Menkes fibroblast cultures were established and copper metabolism was investigated. Menkes fibroblasts contained four to six times higher concentrations of copper than control cells. In Menkes cells more than 90% of the intracellular copper was present in cytosol (105,000 x g supernatant fraction); in control fibroblasts the corresponding value was about 67%. During cultivation of fibroblasts in medium supplemented with 100 ng/ml of copper (270 ng CuCl2·2H2O /ml), the amount of copper increased continuously in Menkes cells, at least up to 4 days, while in control cells in reached a maximum after 24 h, followed by a gradual decrease. When the medium was replaced with one without copper chloride, copper concentrations in Menkes cells returned to the original level in three days, whereas those in control cells returned to the normal level in one day. Using Sephadex G-75 column chromatography of cytosol, two copper-containing peaks were observed (peaks 1 and 3, corresponding to the peaks from rat liver cytosol). Approximately 75% of the copper in the cytosol from Menkes cells was eluted in peak 3. The corresponding copper peak was very small in control cells. Copper peaks 1 and 3 from both cells increased after treating cells with copper chloride and the increase was inhibited by cycloheximide, an inhibitor of protein biosynthesis. Metallothionein purified from human kidneys was eluted as a single copper-protein from a Sephadex G-75 column in the same fractions as peak 3. SDS polyacrylamide-slab gel electrophoresis of the purified metallo-thionein and the material eluted in peak 3 from Menkes fibroblasts showed single peaks for copper at identical migration distances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441474
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  • 8
    Electronic Resource
    Electronic Resource
    Quantitative determination of urinary protein components of children with postural proteinuria (1983)
    Springer
    European journal of pediatrics 140 (1983), S. 268-272 
    Details
    ISSN: 1432-1076
    Keywords: Postural proteinuria ; Urinary protein components ; Upright lordotic posture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-one protein components were measured in urine specimens from 12 subjects with postural proteinuria in the recumbent posture and after a period of upright lordotic posture. The lordotic posture produced an increased urinary excretion of total protein and 19 protein components, particularly of albumin, IgG globulin, and transferrin (128, 68, and 167-fold, respectively). However, 90 min after the lordotic posture, most of the protein components returned to initial values, whereas albumin, IgG globulin, and transferrin remained high. β2-Microglobulin, retinol binding protein, and lysozyme showed the smallest increases after the lordotic posture. These findings suggest that proteinuria occurring after the lordotic posture may be characterized by an increased glomerular permeability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443374
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructure of transplant glomerulopathy (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 4 (1980), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirty-one specimens of tissue were obtained from 15 renal allografts 3–96 months after transplantation and studied by light, electron and in some cases also by immunofluorescence microscopy. All patients had a degree of renal insufficiency and almost all had proteinuria and moderate hypertension; nephrotic syndrome was present in one and hematuria in two. On histological examination one patient showed cellular proliferation suggestive of glomerulonephritis (recurrent or de novo) and another patient had numerous crescents. The most frequent glomerular lesion was widening of the lamina rara interna with subendothelial accumulation of finely granular material, formation of new subendothelial basement membrane and deposition of microfibrils and fine filaments. The mesangial changes were mainly those of mesangiolysis and mesangial sclerosis with deposition of mesangial matrix and microfibrils, but little cellular proliferation. Fragmented red blood cells were seen in nearly half of the patients. In another seven patients the lesion resembled focal segmental glomerulosclerosis. This combination of changes termed transplant glomerulopathy leads to diffuse glomerular sclerosis. Arterial intimal thickening and occasionally also thrombosis produced ischaemic changes in the kidney and in the glomeruli and contributed significantly to the process of transplant rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1980.tb02931.x
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  • 10
    Electronic Resource
    Electronic Resource
    IMMUNOHISTOCHEMICAL STUDY OF α-FETOPROTEIN IN RAT EMBRYOS DURING ONTOGENESIS (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 417 (1983), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1983.tb32866.x
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