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Epidermal surface receptors which link pharmacological mediators to the adenylate cyclase system (1982)

ADACEHI, K. ; HALPRIN, K.M. ; TAKEDA, J. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

British journal of dermatology 107 (1982), S. 0

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ISSN: 1365-2133

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: The major purpose of our studies has been to investigate various stimulators of the epidermal adenylate cyclase system. We have recognized the occurrence of four distinct adenylate cyclase systems which respond respectively to catecholamine, histamine, prostaglandin and adenosine. The exposure of floating skin slices in vitro to a stimulator causes a rapid intracellular accumulation of cyclic AMP, which is always transient. Further addition of the same stimulator will not stimulate the same receptor system against the state of ‘refractoriness’. The addition of any of the other stimulators can increase the cyclic AMP level. Furthermore, the fact that each stimulator can yield an ‘additive’ stimulatory effect leads to the conclusion that the epidermis has four distinctly specific and independent adenylate cyclase systems.Our recent investigations have been directed to the analyses of subunits of these skin surface receptor-adenylate cyclase systems. We used two experimental systems, i.e. one being a ‘leaky’ cell system in which its subunits such as receptor, GTP-regulatory protein and the catalytic unit (adenylate cyclase) are still linked togetlier, and the other being independent preparations of the receptor and catalytic units (with GTP-regulatory protein). These systems allowed us to probe the cell membrane from the inside as well as from the outside. Some of our preliminary kinetic data are herein introduced.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb01042.x

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Synthesis of aromatic polyimines by the condensation of aromatic dialdehyde and diamine (1983)

Suematsu, K. ; Nakamura, K. ; Takeda, J.

Springer

Colloid & polymer science 261 (1983), S. 493-501

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ISSN: 1435-1536

Keywords: Aromatic polyimines ; polycondensation ; m-cresol ; film-forming ; high glass transition

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Abstract Film-forming aromatic polyimines were prepared by low temperature solution polymerization of aromatic dialdehyde and aromatic diamine usingm-cresol. The polymerization proceeded rapidly to give high molecular weight polyimine solutions. Fibrous polymers were precipitated by pouring the solutions into anhydrous methanol. Lemon yellow-to-orange films were cast in situ from the reaction solutions. The polymers showed typical C=N stretching absorption near 1620 cm−1 in infrared spectra and had high glass transitions of over 200