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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis of PHI (peptide histidine isoleucine) and related peptides and immunochemical confirmation of amino acid residue in position 24 of PHI with use of the synthetic peptides (1984)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 106 (1984), S. 7909-7916 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00337a046
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  • 2
    Electronic Resource
    Electronic Resource
    An autopsy case of acute porphyria with a decrease of both uroporphyrinogen I synthetase and ferrochelatase activities (1984)
    Springer
    Acta neuropathologica 64 (1984), S. 6-11 
    Details
    ISSN: 1432-0533
    Keywords: Acute porphyria ; Porphyric neuropathy ; Axonal degeneration ; Uroporhyrinogen I synthetase ; Ferrochelatase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of a 37-year-old woman with acute porphyria is reported. The patient began to complain of severe menstrual pains, and later developed serious peripheral neuropathy and various autonomic nervous symptoms. The autopsy revealed a marked loss and degeneration of axons and myelin sheaths in the peripheral nervous system (PNS), and prominent central chromatolysis of the spinal anterior horn cells. The predominant process of the peripheral neuropathy appeared to be axonal degeneration. Biochemical analysis showed a marked increase of delta-aminolevulinic acid (ALA), porphobilinogen, uroporphyrin, and coproporphyrin in the urine, and an increase of coproporphyrin and protoporphyrin in the stools and blood. In the analysis of the enzymatic activities of the liver and bone narrow, the activity of ALA synthetase (ALA-S) was markedly increased, and the activities of both uroporphyrinogen I synthetase (URO-S) and ferrochelatase were decreased. It was characteristic in this case that the enzymatic abnormalities found in both acute intermittent porphyria (AIP) and variegate porphyria (VP) coexisted. Biochemical analysis of the sciatic nerve showed an increase of ALA-S activity and a decrease of both URO-S and ALA dehydrase activities. This was the first report that indicated the presence of abnormal activities of the heme biosynthetic enzymes in the peripheral nerves of porphyric patients. The possibility was discussed that these enzymatic abnormalities of the heme biosynthesis in the peripheral nerve itself might be strongly related to the pathogenesis of the porphyric neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00695599
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  • 3
    Electronic Resource
    Electronic Resource
    Distribution of intracytoplasmic acidophilic granule-containing neurons in the human brain (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 145-148 
    Details
    ISSN: 1432-0533
    Keywords: Intracytoplasmic acidophilic granules ; Distribution ; Lewy bodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using four autopsied brains, we studied the anatomic locations of the intracytoplasmic acidophilic granule (IAG)-containing neurons. These neurons occurred in the hypothalamus, zona incerta, insular cortex, and the other 23 nuclei. However, IAGs were not observed in neurons of the Ammon's horn, thalamus, dentale nucleus, or in Purkinje cells of the cerebellum. The distribution of IAG-containing neurons does not exactly correspond to that of the neuromelanin- or monoamine-forming neurons. There is, however, a striking parallelism between the IAG-containing neurons map and the Lewy bodies map. It is suggested by the superimposition of both maps that IAG-containing neurons may have a certain metabolic relation to the formation of Lewy bodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685360
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  • 4
    Electronic Resource
    Electronic Resource
    Light- and electron-microscopic studies of intracytoplasmic acidophilic granules in the human locus ceruleus and substantia nigra (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 78-80 
    Details
    ISSN: 1432-0533
    Keywords: Intracytoplasmic acidophilic granules ; Melanin-bearing neurons ; Round electron-dense body ; Mitochondrial inclusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the brains of 30 patients with mental and neurologic disorders, we studied the intracytoplasmic acidophilic granules in neurons of the substantia nigra and locus ceruleus by light and electron microscopy. The granules were present in all 30 brains, including those with no recognizable pathologic change, there was no correlation between their appearance and the age, sex, disease of, or the medication received by, the patients. In four electron-microscopically examined brains, we noted many small, round electron-dense bodies in the perikarya and neuronal processes of the substantia nigra and locus ceruleus. The bodies were packed tightly within a double membrane; in shape, size, and distribution in the neuronal cytoplasm, they corresponded to acidophilic granules. Some mitochondrial matrices contained one or more similar, but smaller inclusion bodies; larger bodies pushed aside the mitochondrial cristae. We conclude that the acidophilic granules represent highly developed forms of mitochondrial inclusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691186
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  • 5
    Electronic Resource
    Electronic Resource
    Converging patterns of finger representation and complex response properties of neurons in area 1 of the first somatosensory cortex of the conscious monkey (1983)
    Springer
    Experimental brain research 51 (1983), S. 327-337 
    Details
    ISSN: 1432-1106
    Keywords: Postcentral gyrus ; Area 1 ; Finger representation ; Neural integration ; Monkeys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The representation of the hand and fingers in area 1 of the first somatosensory cortex was studied in conscious monkeys by recording single neuronal activity. The results are as follows. (1) We found multi-finger type receptive fields which cover more than one finger discontinuously or wide-field type ones which cover both finger and palmar skin or two halves of the palmar skin together. Multi-finger type receptive fields were also found in some joint manipulation neurons. Multifinger or wide-field type receptive fields were found in nearly 40% of area 1 neurons. The rate was even higher, up to 70%, in the medial part of the cortical finger region. Consequently, the finger representation in area 1 was less discretely somatotopic than that in area 3b. (2) The submodality content of area 1 was almost identical to that of area 3b: 74.5% and 20.9% of identified neurons were, respectively, cutaneous and deep. The distribution of neurons with different submodalities overlapped in area 1. (3) Among area 1 neurons with multi-finger type receptive fields, response characteristics of those with inhibitory receptive fields, those with directional selectivity to moving stimuli, and those with converging afferent inputs, were studied in detail. Evidence is presented to suggest that information from different parts of the body, or from the same body parts but different afferent sources, is integrated in area 1. (4) It is proposed that, within the SI, area 1 is the initial stage of integration of sensory information coming from the thalamus and from area 3a or 3b via cortico-cortical connections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237869
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  • 6
    Electronic Resource
    Electronic Resource
    Functional subdivisions representing different finger regions in area 3 of the first somatosensory cortex of the conscious monkey (1983)
    Springer
    Experimental brain research 51 (1983), S. 315-326 
    Details
    ISSN: 1432-1106
    Keywords: Postcentral gyrus ; Area 3b ; Finger representation ; Functional subdivisions ; Monkeys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The representation of fingers in the first somatosensory cortex was studied in conscious monkeys by recording single neuronal activity, and the following results were obtained: (1) In area 3a, most neurons responded to joint manipulation or other types of deep stimuli. The representation of five fingers was somatotopically arranged. (2) In area 3b, 77.7% and 20.9% of identified neurons responded to cutaneous and deep stimuli respectively. (3) Neurons responding to light mechanical stimuli and with receptive fields on the distal finger segment were found in the most anterior part of area 3b while those responding better to specific mechanical stimuli, such as rubbing, scraping, pinching, tapping, etc. of finger glabrous skin, were found in the more posterior part. The representation of the five fingers was somatotopically arranged. (4) Neurons responding to light or specific mechanical stimulation of the dorsal hairy skin of fingers were found in the posterior part of area 3b. The independent somatotopic representation of four fingers was recognized within this region. (5) Neurons responding to mechanical stimulation of the palmar skin were found in two separate regions, the medial one for the ulnar half and the lateral one for the radial half of the palm. (6) These results indicate that the representation of fingers in areas 3a and 3b of the conscious monkey is divided into multiple somatotopic subdivisions each representing a functional region of the hand and fingers. (7) Neurons with multi-finger receptive fields were occasionally found in area 3b, mostly in layer VI. Some of them had inhibitory receptive fields. Multifinger type receptive fields were more commonly found in area 1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237868
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  • 7
    Electronic Resource
    Electronic Resource
    Two siblings with cleidocranial dysplasia associated with atresia ani and psoriasis-like lesions: A new syndrome? (1981)
    Springer
    European journal of pediatrics 136 (1981), S. 109-111 
    Details
    ISSN: 1432-1076
    Keywords: Cleidocranial dysplasia syndrome ; Atresia ani ; Urogenital anomalies ; Psoriasis ; Autosomal recessive inheritance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A cleidocranial dysplasia syndrome associated with atresia ani, urogenital anomalies, and psoriasis-like skin lesions is reported in two siblings (1 boy, 1 girl) in a family of Japanese descent. There is no family history of cleidocranial dysplasia syndrome and/or psoriasis. Consanguinity is denied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441723
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of zopiclone on the arousal level of healthy volunteers assessed by the averaged photopalpebral reflex (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 469-474 
    Details
    ISSN: 1432-1041
    Keywords: zopiclone ; nitrazepam ; photopalpebral reflex (PPR) ; hypnotic effect ; side effects ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The averaged photopalpebral reflex (PPR) represents the mean of summed reflex contractions of the orbicularis oculi muscle in response to periodic photic stimuli. The latency of PPR can be used to assess a drug effect on human arousal level, since it is prolonged if there is a reduction in the arousal level of the subject. In the present study of the clinical effects of zopiclone, healthy male volunteers aged 18–22 years were given zopiclone 5 mg and 10 mg, nitrazepam 5 mg and 10 mg, or placebo, in a double-blind, cross-over design. Changes in the latencies of PPR were examined from 0.5 to 4 h after medication. Both zopiclone and nitrazepam prolonged the latency in a dose-dependent manner, but the prolongation induced by zopiclone appeared more rapidly, was slightly more marked and lasted for a shorter period than that induced by nitrazepam. Zopiclone produced slightly fewer subjective changes, such as vagueness of thought and weakness, than did nitrazepam. From these results, it is suggested that zopiclone possesses a potent hypnotic action which appears more rapidly and is slightly more potent and shorter lasting than that of nitrazepam. In addition, zopiclone may also exhibit fewer side effects, such as vagueness of thought and weakness than nitrazepam, and it may cause less “hang over”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609888
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  • 9
    Electronic Resource
    Electronic Resource
    Lattice-image interpretation of a relatively-small-unit-cell crystal (1984)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 40 (1984), S. 143-151 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Many-beam lattice images obtained at 200 kV from V2O3 crystals are discussed in comparison with those calculated in the Bloch-wave approach. The technique of optical diffractogram and equal-thickness fringes is utilized, if possible, to determine the defocus value and the crystal thickness which are the essential parameters for objective interpretation at atomic resolution. Whereas images observed in a thin region (∼ 50 Å) of crystal have been reproduced fairly well by simulation, there are others from thicker regions which are not always explained for lack of knowledge of the parameters. As for the effect of the partial coherence, the validity of the envelope-function approximation is examined with the aid of the first principle involving image-intensity summation, and under the experimental conditions used it proved to be satisfactory for qualitatively reproducing the observed image even for relatively thick (∼ 450 Å) regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767384000313
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  • 10
    Electronic Resource
    Electronic Resource
    Many-beam lattice images calculated at 100 kV and 1000 kV (1980)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 36 (1980), S. 1033-1041 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Lattice images of high-temperature-phase vanadium sesquioxide (V2O3) were calculated within the Bloch-wave approach. At an accelerating voltage of 1000 kV the structure image can be produced while at 100 kV it cannot be obtained because of the small number of reflections available in the image formation, which demonstrates clearly an advantage of high voltages which are produced by improvement in the transfer condition of the objective lens. On the other hand, if an ideal phase-contrast lens is assumed in order to obtain the structure image at 100 kV, lattice-image calculations can be carried out with modified unit-cell size. The results show that the maximum allowable thickness to obtain the structure image varies more rapidly than in a linear manner with the required resolution. The maximum allowable thickness increases either with higher voltages (from about 20 Å at 100 kV to about 35 Å at 1000 kV) or with larger unit cells (e.g. a dilatation of 25% in unit-cell size increases the maximum thickness from about 20 to about 35 Å). However, the evolution of the image details as a function of crystal thickness is different for these two factors, due to the different dynamical interactions of electron waves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567739480002094
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