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  • 1
    Digitale Medien
    Digitale Medien
    Histopathological characteristics and oestrogen receptor content in primary breast carcinoma (1981)
    Springer
    Virchows Archiv 390 (1981), S. 347-351 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Breast carcinoma ; Oestrogen receptor ; Histology ; Cellularity ; Elastosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 159 primary breast carcinomas were examined histologically with regard to grade of anaplasia, cellularity, amount of elastic tissue, and whether they were of ductal or lobular origin. Possible correlations between these variables and the oestrogen receptor (OR)-content were investigated. There was a marked tendency toward a greater number of OR-positive tumors in the group rich in elastosis. A significant correlation between the OR-content and the histological grade was found, whereas there was no correlation between either the OR-content or the grade of anaplasia and the cellularity. Furthermore, the group of tumors that were lobular in derivation had a significantly greater number of OER-positive tumors than the group ductally derived.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00496564
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  • 2
    Digitale Medien
    Digitale Medien
    Species differences in the expression of carbohydrate differentiation antigens on mammalian blood cells revealed by immunofluorescence with monoclonal antibodies (1984)
    Springer
    Bioscience reports 4 (1984), S. 673-685 
    Details
    ISSN: 1573-4935
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Following recent observations using monoclonal antibodies that carbohydrate structures behave as differentiation antigens of man and mouse, we have made a preliminary survey of the expression of 8 monoclonal antibody-defined carbohydrate antigens on blood cell smears of man, baboon, mouse, rat, rabbit, pig, and dog. There are considerable species differ-ences in the patterns of antigen expression. However, certain generalizations can be made as follows: the i and I antigens, associated with linear and branched carbohydrate chains consisting of repeating N-acetyl-lactosamine sequences (GalB1-4GIcNAc, termed Type-2 backbone sequences) are widely distributed among granulocytes and lymphocytes of all the species studied, and on erythrocytes, monocytes, and piateiets of some of them. Substantial amounts of Type-1 backbone sequences (GalB1-3GlcNAc) may occur on rabbit lymphocytes. The N-acetylneuraminic acid-containing antigens, Pr 2 and Gd, are also expressed to varying degrees on blood cells. On the other hand, antigens based on mono- and diiucosylated N-acetyllactosamine, termed SSEA-1 (or X-hapten) and C14 (or Y-hapten) are predominantly granulocyte/monocyte-associated antigens. The former antigen is expressed in overt form only on untreated human granulocytes but occurs in cryptic state , masked by sialic acid, on human monocytes, and on the granulocytes and monocytes of baboon, rabbit, and dog but not on those of mouse, rat, and pig. The latter antigen is expressed on human granulocytes and on neuraminidase-treated monocytes and granulocytes oi dog. Lymphocytes of dog are unusual in their expression of C14 antigen, in cryptic state, masked by sialic acid residues. Although the physiological roles of these various carbohydrate structures , in vivo, are not yet known, they seem excellent candidates as determinants of species and cell-type differences in susceptibilities to infective agents.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01121021
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  • 3
    Digitale Medien
    Digitale Medien
    The influence of parity on estrogen and progesterone receptors in primary breast cancer (1982)
    Springer
    Breast cancer research and treatment 2 (1982), S. 414-416 
    Details
    ISSN: 1573-7217
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01805888
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  • 4
    Digitale Medien
    Digitale Medien
    Monoclonal antibodies applied to primary human breast carcinoma: Relationship to menopausal status, lymph node status, and steroid hormone receptor content (1982)
    Springer
    Breast cancer research and treatment 2 (1982), S. 401-405 
    Details
    ISSN: 1573-7217
    Schlagwort(e): differentiation markers ; human breast carcinomas ; monoclonal antibodies ; prognostic factors ; steroid receptor
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Monoclonal antibodies were raised against purified human milk fat globule membranes. The binding of three of these (Mam-3, HMFG 1, and HMFG 2) to fixed histological sections of 100 primary breast carcinomas has been investigated. Tissue specificity was investigated by testing the binding of the antibodies to carcinomas from other organs and to benign proliferative breast lesions. In breast tissue, antigens were found only in the epithelial cells, while the stromal component, myoepithelium, and any inflammatory cells present were negative. The reaction was characterized by considerable heterogeneity, both with regard to the percent of cells positive and the intensity of the reaction. No relationship was observed between binding and histological type of breast carcinoma. However, in ductal infiltrating carcinomas, a tendency towards a greater proportion of tumors that bound the antibodies was observed among the highly differentiated compared to the low differentiated carcinomas. Data on estrogen and progesterone receptors were available in 53 and 22 of the 100 carcinomas, respectively. There were no apparent relationships between the presence of surface antigens and the menopausal status, lymph node status, or estrogen receptor status, but the tumors lacking progesterone receptor apparently lacked the antigens as well. The presence of surface antigens probably defines a differentiation in primary breast carcinoma. Whether this differentiation is of any prognostic significance remains to be established.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01805883
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  • 5
    Digitale Medien
    Digitale Medien
    Antiestrogen treatment of postmenopausal women with primary high risk breast cancer (1983)
    Springer
    Breast cancer research and treatment 3 (1983), S. 77-84 
    Details
    ISSN: 1573-7217
    Schlagwort(e): breast cancer ; estrogen receptor ; progesterone receptor ; risk factors ; tamoxifen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The role of antiestrogen treatment in high risk postmenopausal patients with primary breast cancer is currently evaluated in a nationwide, prospective randomized trial conducted by the Danish Breast Cancer Cooperative Group. The primary treatment is total mastectomy and radiotherapy. As of February 1, 1982, 720 women were randomized to treatment with tamoxifen (30 mg daily for 1 year) and 691 women were randomized to no further therapy. Life-table analysis after 36 months shows a difference in recurrence rates of 9% (p = 0.19) in favor of the tamoxifen-treated patients. The material has been analyzed with respect to established prognostic factors such as age, degree of anaplasia, tumor size, and number of positive nodes. The rates of recurrent disease are lower in all subsets of patients treated with tamoxifen, but are only statistically significant in patients 50–59 years of age or with 4 or more positive lymph nodes. Regardless of treatment, ER negative patients have a 23% higher recurrence rate than ER positive patients after 18 months of analysis (p = 0.0033); this represents an approximate doubling of risk, and is independent of age, degree of anaplasia, tumor size, or lymph node status. With regard to PgR status, there is 11% higher recurrence rate in the PgR negative than in the PgR positive patients (p = 0.097).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01806237
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  • 6
    Digitale Medien
    Digitale Medien
    Estrogen and progesterone receptor profile patterns in primary breast cancer (1983)
    Springer
    Breast cancer research and treatment 3 (1983), S. 103-110 
    Details
    ISSN: 1573-7217
    Schlagwort(e): estrogen receptor ; progesterone receptor ; receptor ratios
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Estrogen (ER) and progesterone receptor (PgR) analyses have been performed in 884 primary, malignant human breast tumor biopsies. Receptor contents were evaluated with respect to age and menopausal status. The frequency of ER + tumors was found to be significantly higher in postmenopausal than in pre/perimenopausal women. Age rather than menopausal status was found to be associated with this difference. The significant association with age was found in the post- but not the pre/perimenopausal women. The frequency of PgR + tumors was found to be significantly lower in the postmenopausal than in the pre/perimenopausal women. Neither age nor menopausal status alone could account for this difference, which appears to be due to a compound effect of the two factors. The distribution of receptor profile patterns is described according to menopausal status. The patterns differ significantly in pre- and postmenopausal women. PgR dominates in the premenopausal tumor while ER dominates in the postmenopausal tumor. This difference is apparent within the subgroup of ER + PgR + patients as well. The current tenets for prediction of recurrent disease utilizing steroid hormone receptor determinations are discussed for the group of ER + PgR + patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01806241
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