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  • 1
    Electronic Resource
    Electronic Resource
    Diagenetic processes and the mineralization in the triassic of Central England (1983)
    Springer
    Mineralium deposita 18 (1983), S. 365-377 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Continental red beds are the host rocks of a characteristic style of mineralization which suggests a genetic link between red bed formation and ore formation. Samples of unmineralized and mineralized Triassic sediments from Central England have been studied sedimentologically, petrographically and geochemically with the aim of clarifying this link which may provide valuable guides for exploration. On the basis of sedimentological and petrographic observations it is suggested that these red beds were formed as a result of diagenetic alteration whereby detrital silicates and oxides are progressively dissolved and the iron released is deposited as hematite. A model for mineralization is proposed involving the release of trace metals from detrital minerals during diagenesis, their retention in saline interstitial solutions, migration to suitable sites of precipitation and deposition by reaction with trapped hydrocarbons or reduced sulphur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206485
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Should erythromycin dose be altered in haemodialysis patients? (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 435-440 
    Details
    ISSN: 1432-1041
    Keywords: erythromycin ; haemodialysis ; dosage adjustment ; pharmacokinetics ; protein-binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Erythromycin kinetics were studied in 17 patients with end stage renal failure treated with maintenance haemodialysis and 9 normal volunteers to discover if dialysis patients needed a modified dose. The elimination half life in dialysis patients (on dialysis days) was similar to that reported in normal subjects. Only small amounts of drug appeared in the dialysate, no patient loosing more than 9 mg in one dialysis. Both patients and volunteers had similar plasma concentrations 8 h after the end of a 5-day course. Protein-binding did not change significantly during dialysis and was similar to that reported in normal subjects. We conclude that dialysis patients requiring 1.5 g of erythromycin stearate daily or less can be given normal doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00605994
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A double blind trial of UK-38,485, an orally active thromboxane synthetase inhibitor, in the treatment of Raynaud’s syndrome (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 61-65 
    Details
    ISSN: 1432-1041
    Keywords: thromboxane synthetase inhibitors ; Raynaud’s syndrome ; systemic sclerosis ; UK-38,485 ; ischaemic attacks ; red blood cell rheology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten patients with moderate to severe Raynaud’s syndrome were recruited into a four week randomised double blind crossover study to compare the efficacy of UK-38,485 50 mg, a new thromboxane synthetase inhibitor with that of placebo. With the doses used there was no significant difference between the two treatment periods in the number, severity and duration of ischaemic attacks, the mean hand temperatures, forearm and digital blood flow and red blood cell rheology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02395208
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of chlorpromazine and other drugs acting on the central nervous system on human sperm motility (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 413-416 
    Details
    ISSN: 1432-1041
    Keywords: chlorpromazine ; sperm motility ; central nervous system depressant ; caffeine ; membrane stabilizing effect ; fertility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The in vitro effects of chlorpromazine, diazepam, phenytoin and phenobarbitone on human sperm motility were investigated. Only chlorpromazine inhibits human sperm motility and the concentration which decreases sperm motility to 50% of control is 0.22 mM. Caffeine can shift the dose-response curve of chlorpromazine-inhibited sperm motility to right. We support the hypothesis that chlorpromazine acts on the cellular membrane but consider the inhibition of sperm motility an unlikely cause of decreased fertility in chlorpromazine treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542545
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  • 5
    Electronic Resource
    Electronic Resource
    A double blind trial of UK-38,485, an orally active thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 61-65 
    Details
    ISSN: 1432-1041
    Keywords: thromboxane synthetase inhibitors ; Raynaud's syndrome ; systemic sclerosis ; UK-38,485 ; ischaemic attacks ; red blood cell rheology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten patients with moderate to severe Raynaud's syndrome were recruited into a four week randomised double blind crossover study to compare the efficacy of UK-38,485 50 mg, a new thromboxane synthetase inhibitor with that of placebo. With the doses used there was no significant difference between the two treatment periods in the number, severity and duration of ischaemic attacks, the mean hand temperatures, forearm and digital blood flow and red blood cell rheology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553156
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of a new antiarrhythmic agent, flecainide acetate, on systolic time intervals (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 13-18 
    Details
    ISSN: 1432-1041
    Keywords: flecainide ; antiarrhythmic agent ; systolic time intervals ; heart functions ; conduction delay ; myocardial contractility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We investigated the effect of flecainide on systolic time intervals in 6 healthy subjects. A randomized, double blind, cross-over study was designed using flecainide (2 mg/kg), propranolol (0.2 mg/kg) or saline. In comparison with placebo, flecainide increased heart rate, diastolic BP, QT-Index, QS2-Index, PEP, and reduced LVET-Index (p〈0.05). It caused a significant increase in PR interval, QRS duration, and PEP/LVET (p〈0.01). Propranolol, compared with placebo, decreased heart rate and systolic BP (p〈0.05). It increased PR interval, PEP, and PEP/LVET ratio (p〈0.05). In comparison with propranolol, flecainide increased heart rate and QRS duration (p〈0.01, p〈0.001 respectively). It increased diastolic BP, PR interval, QS2-Index, PEP, and PEP/LVET ratio, and decreased LVET-Index (p〈0.05). These changes in STI induced by flecainide may be produced by depression of myocardial contractility. Intraventricular conduction delay may be an additional contributing factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544007
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  • 7
    Electronic Resource
    Electronic Resource
    Preliminary clinical pharmacological studies of S3341, a new hypotensive agent, and comparison with clonidine in normal males (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 281-286 
    Details
    ISSN: 1432-1041
    Keywords: S3341 ; clonidine ; hypotensive drug ; side-effects ; cardiovascular effects ; alpha2-receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary S3341, a new hypotensive agent which binds to alpha2-receptors in animal brain preparations, was studied in normal healthy male volunteers. A dose ranging study with 15 and 25 µg/kg of S3341 was performed in a double blind, placebo controlled randomised and balanced manner with 3 subjects. A decrease or BP without noticeable sedation (assessed by visual analogue scales) was seen. One, 2 mg of S3341, 0.1 and 0.2 mg of clonidine were then compared in a double blind, placebo controlled, randomised and balanced manner in 10 subjects. BP, heart rate, systolic time intervals (STI), critical flicker frequency, choice reaction time, pursuit rotor, stimulated salivary volume, and dryness of mouth and sedation with visual analogue scales, were measured at 0, 1.5, 3.0, 4.5 and 6.0 h after drug administration. The relationship between decreases in BP and sedation was assessed by linear regression analysis, with the former as the independent (predictor) response and the latter as the dependent (response) variate. Both drugs produced a similar decrease of BP which was significantly different from placebo. Changes in psychomotor function tests were not significant. Both drugs produced dryness of mouth and sedation which were significantly different from placebo but changes were less with S3341. Clonidine showed a significantly steeper slope than S3341 in the relationship between decreases in BP and sedation. This must be interpreted with caution as there was wide variation in the correlation between decreases in BP and sedation, but it may be possible to achieve lesser sedation with S3341.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542160
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  • 8
    Electronic Resource
    Electronic Resource
    β-adrenoceptor blockade and migraine (1982)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 2 (1982), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Except for propranolol, no other b-blocker has been studied thoroughly in the prophylaxis of migraine. Of those studied, propranolol, atenolol and timolol were shown to be useful in double-blind clinical trials. The mode, or even the site of action of these drugs is unknown. Possible mechanisms of action are peripheral vascular effects, a central action, 5-HT antagonism, an anxiolytic effect and a multifactorial action. The only common property of the successful drugs is lack of partial agonist activity and their profiles do not fully support any of the above hypotheses. Trials of drugs in the prophylaxis of migraine have in general been unsatisfactory due to the difficulty in controlling many variables. b-blockers with differing properties offer an opportunity to define the properties necessary for anti-migraine activity and perhaps shed light on the pathogenesis of migraine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1982.0201033.x
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  • 9
    Electronic Resource
    Electronic Resource
    Components of A Jungian Theoretical Orientation (1984)
    Oxford, UK : Blackwell Publishing
    The @journal of analytical psychology 29 (1984), S. 0 
    Details
    ISSN: 1468-5922
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1465-5922.1984.00067.x
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  • 10
    Electronic Resource
    Electronic Resource
    Experiments to Assess the Hydraulic Efficiency of Well Screens (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 21 (1983), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: The hydraulic properties of commercial well screens were investigated to determine which screen design features affected head loss. The test program began with laboratory experiments and continued as a field-scale experiment with the installation of a well field in the Thames Valley Gravel Aquifer.The laboratory experiments indicated that, for all practical purposes, the head loss attributable to all of the screens tested was negligible. The experimental head loss, however, did vary from screen to screen, particularly at high intake velocities, and the screens could be ranked on the basis of their hydraulic efficiencies. This efficiency hierarchy is explained tentatively in terms of the screen construction methods and slot geometry. The field experiments showed that the hydraulic performance of all well screens is independent of screen design provided that the open area of the screen is above about 10%. The field experiments also indicated that the development capacity of a screen in a gravel aquifer is not wholly dependent on screen design, but that progressive development does increase the hydraulic efficiency of a well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.1983.tb00722.x
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