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  • 1
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Immune complexes ; Anti-immunoglobulin ; Complement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Circulating immune complexes by fluid phase Clq binding assay, complement components and anti-immunoglobulin levels were studied in sera of 35 patients with rheumatoid arthritis (RA). In 23 of the 35 sera (65.7%), circulating immune complexes were positive, and the mean±SD of Clq binding activity (ClqBA), 44.5±19.4%, was significantly high compared to that of healthy persons, 17.4±8.2%. Antigenic determination of complement components revealed that Clq, C3, C5, C9, factor B and Cl esterase inhibitor (CIINH) were significantly high in sera of RA, but C4 and properdin were not. The disease activity correlated with ClqBA, IgG- and IgM-anti-immunoglobulins, C9 and serum IgG. On the other hand, ClqBA correlated with both IgG- and IgM-anti-immunoglobulin levels but not with complement components.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 91 (1983), S. 139-143 
    ISSN: 1437-1596
    Keywords: Cadmium poisoning by inhalation ; Pulmonary fibrosis ; Alveolar damage by cadmium poisoning ; Kadmiumvergiftung, Inhalation ; Lungenfibrose, alveoläre Schädigung durch Kadmiumdämpfe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Ein 43jähriger Schmelzer wurde dem beim Schmelzen von „Kupferabfall“ entstehenden bräunlich-gelben Rauch ungefähr 5 Stunden lang ausgesetzt. Nach 2 Tagen trat eine schwere Dyspnoe ein. Bei Aufnahme in ein Krankenhaus wurde eine schwere Hypoxämie entdeckt. Nach der Intubation wurde ein sauerstoffreiches Gasgemisch verabreicht. Die Sauerstoffkonzentrationen der Einatmungsluft wurden allmählich gesteigert, jeoch schritt der Grad der Hypoxie fort. Der Kranke starb 12 Tage nach dem Unfall. Die wesentlichen Sektionsbefunde waren auf die Lunge beschränkt. Beide Lungenflügel waren schwer (die linke wog 1470 g und die rechte 1710 g) und derb. Histologisch wurden nirgends normale Alveolen gefunden. Mehrere Alveolarräume enthielten abgelöste Alveolarepithelien oder organisiertes Exsudat. Unter Berücksichtigung der oben genannten Befunde lautete die Diagnose „diffuse alveolare Schädigung“. Aufgrund des vorhandenen Kadmiums im „Kupferabfall“, der Eigenschaft des Rauches, dem klinischen Bild und der hohen Kadmiumkonzentration in der Lunge wurde die Ursache der Lungenveränderungen dem Kadmiumdampf im Rauch zugerechnet. Verglichen mit den Lungenveränderungen, die in ähnlichen Fällen beschrieben wurden, waren die Veränderungen in diesem Falle in weit fortgeschrittenerem Stadium.
    Notes: Summary A 43-year-old male smelter was admitted to a hospital on account of severe dyspnea about 2 days after exposure to brownish-yellow smoke produced by melting of “copper” scrap. On admission pronounced hypoxemia was revealed, and an oxygen-enriched gas was administered after intubation. Although inspired oxygen concentration was gradually increased, hypoxemia progressed and he died on day 11 in hospital. The principal autopsy finding was chiefly confined to the lungs. Both lungs were heavy (the left weighing 1,470 g; the right 1,710 g) and firm to the touch. Histologically, no normal alveoli were found throughout the entire lung. Some alveolar spaces were occupied by pneumocytes, others by organized exudate with fibrosis. Interstitial fibrosis was present. Patchy areas of inflammatory cell infiltrations as well as intra-alveolar hemorrhages were observed. On the basis of the above findings a diagnosis of diffuse alveolar damage was made. Based on the available evidence (presence of cadmium in the “copper” scrap, feature of the smoke, clinical signs with latent time, and high cadmium concentration of the lung), the diffuse alveolar damage was considered to have been caused by inhaled cadmium. The pulmonary change of the present case was more advanced in pathologic stage in comparison with those reported in the literature.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0173-2803
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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