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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 27 (1984), S. 163-165 
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes ; rat ; autoimmunization ; streptozotocin ; polyclonal lymphocyte activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The non-specific activation of the immune system by administration of complete Freund's adjuvant was examined in Wistar rats as a possible means of amplification of the specific immune response directed to pancreatic β cells caused by low dose non-diabetogenic multiple injections of streptozotocin. Rats were given intraperitoneally 0.5 ml of complete Freund's adjuvant to induce polyclonal lymphocyte activation and, 1 day later, the animals were given an intraperitoneal injection of 15 mg streptozotocin/kg body weight (group 1). This combined treatment was given twice at weekly intervals. In two further groups, rats were treated with complete Freund's adjuvant alone (group 2) or streptozotocin alone (group 3) with the same doses and at the same times. Only the rats in group 1 developed delayed but severe and persistent hyperglycaemia. In addition, significant complement-dependent cytotoxicity was detected in nine out of 15 rats (60%) in group 1 in islet cells, but not in spleen lymphocytes. The pancreatic insulin content of the rats in group 1 was depleted by up to 3.1 ± 0.5%. With these experiments, a new animal model for insulin-dependent diabetes is described; complete Freund's adjuvant/streptozotocin diabetes. In many aspects, this model of diabetes parallels the development of insulin-dependent diabetes in man, including the humoral autoimmunity to islet cell antigens.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 229 (1983), S. 237-245 
    ISSN: 1432-1459
    Keywords: Disability evaluation ; Isoniazid ; Huntington's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über 11 Patienten mit Huntingtonscher Krankheit berichtet, die in hoher Dosierung Isoniazid erhielten. Neben der klinischen Beurteilung erfolgte eine Quantifizierung des Behinderungsgrades. 4 Patienten wiesen eine eindeutige Besserung der Symptome und eine Abnahme der Behinderung auf. Ein Patient mit der rigiden Form (Westphal-Variante) verschlechterte sich und die restlichen 6 Patienten zeigten keine Änderung des Zustandsbildes. Es scheint, daß besonders die Patienten auf die Isoniazidtherapie ansprechen, bei denen die psychische Beeinträchtigung im Vordergrund steht.
    Notes: Summary Eleven patients with Huntington's disease were treated with high doses of isoniazid. In addition to the clinical assessment, the functional capacity was evaluated quantitatively. The symptoms of four of the patients showed a marked improvement and their functional capacity increased. The condition of one patient with the rigid form (Westphal's variant) deteriorated, and the remaining six patients showed no change. Patients with prominent mental disturbances appeared to respond best to isoniazid therapy.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 15 (1982), S. 95-110 
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using a transmission type polarimeter, an asymmetry has been found that can be ascribed to a circularly polarized component in the bremsstrahlung beam of unpolarized relativistic electrons from the Mainz electron linac, in the region of electron energiesE el between 140 and 400 MeV. The experiment is described in detail. Systematical errors are discussed. For a comparison with electroweak theory, an exact calculation for small photon emission angles (of the order ofm c 2/E el) is needed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 301 (1980), S. 139-140 
    ISSN: 1618-2650
    Keywords: Best. von Molekulargewichten ; Sedimentationsgeschw., Ultrazentrifuge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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